Topic
Intraocular pressure
About: Intraocular pressure is a research topic. Over the lifetime, 25206 publications have been published within this topic receiving 607820 citations. The topic is also known as: IOP.
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TL;DR: Age, male gender, high intraocular pressure, and family history of open-angle glaucoma were major risk factors; the latter association was stronger in men than women and the role of vascular risk factors is consistent with the finding of low blood pressure to intraocular Pressure relationships.
Abstract: Objective: To evaluate risk factors for open-angle glaucoma among black participants in the Barbados Eye Study. Design: Population-based study of demographic, medical, ocular, familial, and other factors possibly related to open-angle glaucoma. Setting and Participants: The Barbados Eye Study included 4709 Barbados residents identified by a simple random sample of Barbadian-born citizens, 40 to 84 years of age; participation was 84%. This report is based on the 4314 black participants examined at the study site; 302 (7%) met the Barbados Eye Study criteria for open-angle glaucoma. Data Collection: A standardized protocol included applanation tonometry, Humphrey perimetry, fundus photography, blood pressure, anthropometry, and an interview. An ophthalmologic examination was performed for participants who met specific criteria. Main Outcome Measures: Open-angle glaucoma was defined by the presence of both characteristic visual field defects and optic disc damage. Association of open-angle glaucoma with specific factors was evaluated in logistic regression analyses. Results: Age, male gender, high intraocular pressure, and family history of open-angle glaucoma were major risk factors; the latter association was stronger in men than women. Lean body mass and cataract history were the only other factors related to open-angle glaucoma. Although hypertension and diabetes were common in Barbados Eye Study participants, they were unrelated to the prevalence of open-angle glaucoma. However, associations were found with low diastolic blood pressure-intraocular pressure differences and low systolic and diastolic blood pressure/intraocular pressure ratios. Conclusions: In the Barbados Eye Study black population, persons most likely to have open-angle glaucoma were older men and had a family history of open-angle glaucoma, high intraocular pressure, lean body mass, and cataract history. These results suggest the importance of possible genetic or familial factors in open-angle glaucoma. The role of vascular risk factors is consistent with our finding of low blood pressure to intraocular pressure relationships, but the results could be explained by the high intraocular pressure in open-angle glaucoma.
742 citations
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TL;DR: Measurements obtained with Goldmann-type tonometers can be used with confidence to monitor changes in the intraocular pressure of an individual, but should not be relied on to determine the absolute manometric pressure within an eye or to compare the IOPs in eyes of different individuals.
740 citations
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TL;DR: The novel ophthalmic formulations CsA 0.05% and 0.1% were safe and effective in the treatment of moderate to severe dry eye disease yielding improvements in both objective and subjective measures.
739 citations
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TL;DR: The factors that affect the rate of progression help decide the expected prognosis of the individual's untreated disease and thereby the frequency of follow-up and aggressiveness of the therapy to be undertaken.
712 citations
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TL;DR: Findings indicate a multifactorial etiology of OAG and suggest that similar risk factors apply across populations, where the established factors of older age, higher IOP, and family history contributed to risk.
700 citations