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Showing papers on "Iodine published in 1981"


Journal ArticleDOI
TL;DR: In vivo estimations of iodine concentrations are subject to considerable variation and the chance to conceal a lesion in these organs increases significantly when performed at a later stage after contrast administration, that is, in the equilibrium phase.
Abstract: The accuracy of in vivo iodine estimations by CT in the aortic blood was determined in the dog. Iodine wash-out curves of five patients each receiving either a bolus of 100 ml diatrizoate 60% or a 10 min infusion of 300 ml diatrizoate 30% and 138 nonenhanced abdominal CT scans with various lesions in 104 patients were analyzed. This investigation suggests: (1) In vivo estimations of iodine concentrations are subject to considerable variation. (2) Iodine accumulation and wash-out for a given contrast administration mode are similar in liver, spleen, and pancreas with tissue iodine concentrations always below blood iodine concentrations, while a significant iodine concentration above iodine blood levels is found in the renal parenchyma. (3) If contrast enhancement is analyzed separately for bolus effect (arteriovenous iodine difference [AVID] greater than 30 H), nonequilibrium phase (AVID 10-30 H) and equilibrium phase (AVID less than 10 H), a good correlation between aortic blood and tissue iodine concentration is found for the latter two phases in the kidney, liver, and spleen which is independent of the contrast administration mode. (4) Visualization of all focal (cystic and solid) lesions is improved in the kidneys after contrast enhancement, while in the other investigated abdominal organs only cystic lesions are always better visualized on the enhanced scan regardless of contrast material dose, administration mode, and time of scanning. (5) Improved visualization of a solid lesion in liver, spleen, and pancreas is most likely achieved by scanning during bolus effect and the nonequilibrium phase, that is, within the first 2 min after a contrast material bolus or during a contrast material infusion. The chance to conceal a lesion in these organs increases significantly when performed at a later stage after contrast administration, that is, in the equilibrium phase.

88 citations



Journal ArticleDOI
TL;DR: The unprecedented development of metastatic thyroid cancer in patients with congenital goiter occurred, in both instances years after subtotal thyroidectomy without thyroid hormone replacement therapy, suggesting a role for TSH in the genesis of human thyroid cancer.
Abstract: We report a large kindred of patients with congenital goiter, followed for 15 yr, in which two siblings (one male and one female) developed metastatic follicular thyroid carcinoma. These two patients were evaluated by iodine kinetic analysis. None of the classical defects of T4 biosynthesis was present in either patient. Rather, both patients had extremely rapid rates of iodine turnover, with elevated 131I uptake and excessive spillage of iodide in the urine. Serum iodoalbumin was present, probably as a nonspecific result of glandular hyperplasia. Iodine kinetic analysis after the ingestion of potassium perchlorate and methimazole was compatible with a leak of nonhormonal iodide from the thyroid. It is not possible to determine whether this iodide leak is the primary pathogenetic defect or is secondary to another unidentified abnormality. The unprecedented development of metastatic thyroid cancer in patients with congenital goiter occurred, in both instances, years after subtotal thyroidectomy without thy...

83 citations


Journal ArticleDOI
TL;DR: A model is proposed according to which oxidation of hormonogenic iodotyrosine residues leads to a charge transfer complex which is the same zwitterion-biradical resonance hybrid no matter whether it resulted from a free radical or an ionic (nonenzymatic) oxidation.

72 citations


Journal ArticleDOI
TL;DR: The present studies were undertaken to analyze the relationships between serum thyroid hormones and TSH concentrations in iodine-deficient pregnantwomen as well as their newborns, and described quantitatively the relationships among iodine intake, thyroid hormones, and T SH.
Abstract: Adaptation to iodine deficiency (ID) requires changes in thyroid and pituitary function that have been well characterized in animals. The present studies were undertaken to analyze the relationships between serum thyroid hormones and TSH concentrations in iodine-deficient pregnantwomen as well as their newborns. The broad range of iodine intake of the population studied, from very low to adequate, allowed us to describe quantitatively the relationships among iodine intake,thyroid hormones, and TSH. The interpretation of the data was supported by the effects that iodinesupplementation had on these various hormones and is consistent with animal observations. About 250 pregnant women from an iodine-deficient area were studied. Fifty percent had a urinary iodine excretion of 50 μg creatinine (cr) or less; 25% had 50∓100 ug I/g-cr, and about 20% had 100∓200 ug I/g cr. Baseline serum hormone concentrations on first examination (mean ± SD) were: T4, 8.0± 0.7 jug⁄dl; T3> 179 ° 45ng⁄dl; rT3, 25 ° 9 ng⁄dl, and TSH,...

70 citations


Journal ArticleDOI
TL;DR: In this article, a kinetic analysis of the catalytic decomposition of hydrogen iodide has been carried out by the use of a flow method at 500-700 K and the platinum-supported active carbon catalyst (1 wt%) and the active carbon catalysts (1 Wt%) were used as the catalysts.
Abstract: The decomposition of hydrogen iodide serves as the hydrogen-evolution step in several thermochemical water-splitting cycles, including the Magnesium–Iodine cycle A kinetic analysis of the catalytic decomposition of hydrogen iodide has been carried out by the use of a flow method at 500–700 K The platinum-supported active carbon catalyst (1 wt%) and the active carbon catalyst which have been found effective in the research reported previously, are used as the catalysts The contact time-conversion relationships for both the catalysts are simulated successfully on the basis of an assumed reaction scheme The influence of water vapor on the rate and the equilibrium of the decomposition of hydrogen iodide is negligibly small The inhibition effect of iodine on the rate of the decomposition of hydrogen iodide over the platinum-supported active carbon catalyst is remarkable below 550 K

66 citations


Journal ArticleDOI
TL;DR: In this article, the authors investigated the early stages of the title reaction in the temperature range of 494-545 K and found that the initial rates were consistent with an iodine atom abstraction chain mechanism, and the bond dissociation energy D(SiH3H) = 378 ± 5 kJ/mol (90 kcal/mol).
Abstract: The title reaction has been investigated in the temperature range of 494–545 K. During the early stages of reaction the only observed products were silyl iodide and hydrogen iodide. Initial rates were found to obey the rate law over a wide range of initial iodine and monosilane pressures. Secondary reactions, most probably of SiH3I with I2, became more important as the reaction progressed. However, provided [SiH4]0/[I2]0 > 20, these secondary processes had a negligible effect on the kinetics, and an integrated rate expression could be used. These kinetics are consistent with an iodine atom abstraction chain mechanism, and for the step has been deduced. From this the bond dissociation energy D(SiH3H) = 378 ± 5 kJ/mol (90 kcal/mol) is obtained. The kinetic and thermochemical implications of this value, especially to the pyrolysis of monosilane, are discussed.

45 citations


Journal ArticleDOI
TL;DR: In this paper, the charge densities and the configurations of iodine doped in poly(2 and 4-vinylpyridines) have been studied by using the Mossbauer effect of 129I at 16 K.
Abstract: The charge densities and the configurations of iodine doped in poly(2‐ and 4‐vinylpyridines) have been studied by using the Mossbauer effect of 129I at 16 K. The ’’outer complex’’ is first formed in the system of poly(2‐vinylpyridine) and iodine. The extent of the charge transfer is estimated to be 0.22 in the outer complex, which is nearly the same as pure pyridine. The iodine of the outer complex varies gradually to the tri‐iodide anion and then to the iodide anion by accepting electrons from the pyridine ring of the polymer. In the system of poly(4‐vinylpyridine) and iodine both the outer complex and the ’’inner complex’’ are first observed, and the iodine species in these complexes vary gradually to the I3− ion and finally to the I− ion in a similar manner as the system of poly(2‐vinylpyridine) and iodine. From the values of the Mossbauer parameters the charge or electron populations of the iodine species are calculated, and the arrangements of these species are discussed.

42 citations


Journal ArticleDOI
TL;DR: In this paper, a mild and efficient method has been developed for carbon-oxygen bond cleavage using chlorotrimethylsilane/sodium iodide in acetonitrile, which was applied to synthetic transformation under nonaqueous and neutral conditions, such as acetal deprotection and the synthesis of phosphonic acids from the corresponding dialkyl phosphonates via methanolysis of their silyl esters.
Abstract: A mild and efficient method has been developed for carbon-oxygen bond cleavage using chlorotrimethylsilane/sodium iodide in acetonitrile. It was applied to synthetic transformation under nonaqueous and neutral conditions, such as acetal deprotection and the synthesis of phosphonic acids from the corresponding dialkyl phosphonates via methanolysis of their silyl esters. Effectiveness of various kinds of metal or ammonium iodides for this type of dealkylation was examined in the acetonitrile solution by 1H NMR. Satisfactory results were also obtained with lithium or potassium iodide in place of sodium iodide. However, copper(I) or quarternary ammonium iodide was ineffective. Chlorotrimethylsilane/lithium bromide in acetonitrile is effective for selective dealkylation of multifunctional phosphonic esters or dialkyl vinyl phosphates.

38 citations


Journal ArticleDOI
TL;DR: In this paper, the aqueous iodide/iodine redox system has proved to be the most favorable electrolyte in designing efficient and stable electrochemical solar cells based on layered semiconducting materials.

37 citations


Journal ArticleDOI
TL;DR: Iodine, as potassium iodide in solution, was added to samples of 24 surface soils, 15 subsoils and 16 mixtures of sand with other materials representing soil components, at 10 μg iodine/g soil.
Abstract: Summary Iodine, as potassium iodide in solution, was added to samples of 24 surface soils, 15 subsoils and 16 mixtures of sand with other materials representing soil components, at 10 μg iodine/g soil. The extent of volatilisation of the added iodine was measured after 30 days' exposure in a well-ventilated room. With many of the surface soils volatilisation was negligible although with an acid sandy podsol it amounted to 57 per cent of the iodine added. Eleven of the subsoils induced volatilisation amounting to > 10 per cent of that added. With sand alone, having a pH of 5.7, volatilisation amounted to 100 per cent, and with the mixtures it ranged from nil to 100 per cent. Organic matter reduced volatilisation, probably by retaining the iodine in bound form. Montmorillonite, kaolinite and ferric oxide also reduced volatilisation in comparison with sand alone, but had less effect than did organic matter. Calcium carbonate, although in general reducing volatilisation, probably through its influence on pH and hence on retention by other materials, caused no reduction when added to sand alone.

Journal ArticleDOI
TL;DR: The electrical conductivity of the charge transfer complex between iodine and polyphenylacetylene (PPA) has been studied in this paper, where the room temperature d-c conductivity increased by seven orders of magnitude with iodine addition, reaching a maximum of 10−5 Ω−1 · cm−1 for a 1:1 ratio of iodine to repeating unit, and its concentration dependence could be described by: σ = σ0 exp [γc(1−c) − γ/4], where c is the mole fraction of iodine.
Abstract: The electrical conductivity of the charge transfer complex between iodine and polyphenylacetylene (PPA) has been studied. The room temperature d-c conductivity (σ) increased by seven orders of magnitude with iodine addition, reaching a maximum of 10−5 Ω−1 · cm−1 for a 1:1 ratio of iodine to repeating unit, and its concentration dependence could be described by: σ = σ0 exp [γc(1–c) – γ/4], where c is the mole fraction of iodine. Both crystalline and amorphous cis-PPA followed this form, the crystalline polymer having a lower conductivity at low iodine levels, but attaining the same maximum value. The trans-polymer iodinated much less readily than cis-PPA. Molecular weight variations did not influence iodine uptake or conductivity in the range studied. It was possible to remove virtually all iodine from the charge-transfer complex in dynamic vacuum, and an iodine diffusion coefficient of D ≈ 10−11 cm2.s−1 was determined from the rate of weight loss. Passage of current resulted in the evolution of iodine and iodine compounds at the anode. The experiment is consistent with a predominantly ionic conduction mechanism, in which the strong concentration dependence of σ is associated with a concentration-dependent activation energy for ionic charge-carrier formation.


Journal ArticleDOI
TL;DR: In this article, the authors assumed four-, five-and six-coordinated IeVI and I0VI species have similar spectra and decay kinetics and negative values of the standard Gibbs energy of formation.
Abstract: Species containing iodine in oxidation state six are formed by photolysis and radiolysis of aqueous iodate and periodate solutions in the following reactions: IO3–+ O–→ IO42–; IO3–+ OH → IO3; IVII+ eaq–→ IeVI and IVII [graphic omitted] I0VI+ O–(or OH). The present pulse radiolysis and laser flash photolysis study of IeVI and I0VI suggests that the predominant IeVI and I0VI species formed are IO42– and IO3 at 3 12. Redox reactions of the iodine(VI) species are fast compared with interconversion among the various iodine(VI) species. The assumed four-, five- and six-coordinated iodine(VI) species have similar spectra and decay kinetics and negative values of the standard Gibbs energy of formation. The spectrum and decay kinetics of the assumed IO3 are markedly different. Furthermore, the standard Gibbs energy of formation of IO3 is estimated to have a large positive value. Observations of reactivity of iodine(VI) towards tert-butanol and periodate suggest that reduction of iodine(VI) to iodate generally takes place by transfer of OH.

Journal ArticleDOI
TL;DR: It is concluded that the mixture was very efficient for decreasing body retention of three important fission products and that it can be used over long periods without causing adverse health effects.

Journal ArticleDOI
TL;DR: The detection of iodine in a thyroid nodule by X-ray fluorescence pre-operatively would significantly decrease the probability of malignancy and the need for surgical excision.
Abstract: Iodine concentration was measured by X-ray fluorescence in 48 normal thyroid glands obtained at autopsy and in 91 surgical thyroid specimens with a variety of abnormalities. The iodine concentration in normal thyroids ranged from 0.02 to 3.12 mg/g of tissue with a mean value of 1.03 ± 0.67 mg/g. The concentrations in pathological specimens were generally lower with the lowest values found in thyroid cancers. Sixteen (76%) of 21 malignant thyroid specimens analysed had undetectable iodine (< 0.02 mg/g) whereas 22 (96%) of 23 benign nodules had measurable iodine concentrations. The detection of iodine in a thyroid nodule by X-ray fluorescence pre-operatively would significantly decrease the probability of malignancy and the need for surgical excision.

Journal ArticleDOI
TL;DR: In this paper, the authors presented extraction equilibrium constants for the extraction of Hg(II) from iodide solutions and Cu(II), Zn(II, and Cd(II)) from hydrochloric acid solutions by aliquat 336 dissolved in chloroform.

Journal ArticleDOI
TL;DR: Human consumption of iodine has increased to amounts which are about equal to the upper safe level as set by the National Research Council, one of the major sources is an increase in the amount reported in milk and other dairy products.

Journal ArticleDOI
TL;DR: It is suggested that internal thyroid iodide is transported from its site of generation, the follicular cell, to its sites of organic binding,the follicular lumen, by perchlorate-sensitive transport, thereby partially preempting the effect whereby PTU causes accumulation of internal iodide in TSH-treated rats.
Abstract: Thyroid iodide labeled 72 h earlier with 131I was separated from organic iodine by polyacrylamide gel electrophoresis. The concentration of thyroid radioiodide was not significantly diminished 2 h after the administration of perchlorate (100 mg NaClO4) alone, but perchlorate reduced the rise in glandular radioiodide caused by simultaneously given TSH (1 IU). When propylthiouracil (PTU; 20 mg) was given along with it, perchlorate decreased thyroid radioiodide even in rats not treated with TSH. In rats given perchlorate, PTU caused a much slighter augmentation of the TSH-induced increase in the thyroid radioiodide concentration than in the absence of perchlorate. These results are interpreted as follows. Perchlorate-discharged iodide in rats not given TSH is largely transported iodide. Perchlorate can discharge intrathyroidally generated (internal) iodide too, but this is unequivocally reflected by a decrease in the thyroid iodide concentration only when the production of internal iodide is enhanced by TSH....

Journal ArticleDOI
TL;DR: It is suggested that the inhibition of organic binding of iodine in the presence of excess iodide may be due to a diminished generation or a decreased availability of hydrogen peroxide in the thyroid.
Abstract: In bovine thyroid slices, the inhibition of organic binding of iodide by excess iodide in the range 5–10 μg/ml was prevented by incubating the slices in the presence of TSH. The Wolff-Chaikoff effect was also overcome by the presence of a hydrogen peroxide-generating system, such as glucose-glucoseoxidase or tyramine. TSH and hydrogen peroxide enhanced the synthesis of both iodotyrosines and iodothyronines. The enhanced organification of iodine in the presence of TSH or hydrogen peroxide was not due to an abrupt synthesis of organic iodine during the early phase of incubation before intrathyroidal iodide concentrations had reached the inhibitory levels. These findings suggest that the inhibition of organic binding of iodine in the presence of excess iodide may be due to a diminished generation or a decreased availability of hydrogen peroxide in the thyroid.

Journal ArticleDOI
TL;DR: The findings of the present work are consistent with the hypothesis that thyroglobulin is arranged in similar or even identical structural domains and that iodination gradually modulates the protein conformation.

Journal ArticleDOI
TL;DR: In this article, six lactating heifers were used in a randomized block design to measure the effects of different levels of iodine supplementation in a canola meal (CM) based concentrate on milk iodine and thiocyanate content.
Abstract: Six lactating heifers were used in a randomized block design to measure the effects of different levels of iodine supplementation in a canola meal (CM) based concentrate on milk iodine and thiocyanate content and thyroid function. The treatments were a pre-experimental control diet (diet C) and a concentrate containing 20% Tower CM (air-dry) with 1.2 (CM-1.2), 2.2 (CM-2.2), 3.3 (CM-3.3) and 4.5 (CM-4.5) mg supplemented iodine/kg concentrate dry matter. The same roughage mixture was fed with all diets. Cows were maintained on diet CM-1.2 for 5 wk, after which they were changed sequentially to diets CM-2.2, CM-3.3 and CM-4.5 at 3-wk intervals. Milk samples were taken and a thyrotropin-releasing hormone test was conducted before the start of the experiment and at the end of each period. Milk samples were also taken daily between days 2 and 6 after diet change-over during treatments CM-2.2, CM-3.3 and CM-4.5. Concentrations of iodide in milk (mean ± SE) for diets C, CM-1.2, CM-2.2, CM-3.3 and CM-4.5 were 42.0...

Journal ArticleDOI
TL;DR: Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should facilitate the safe excretion of 131I.
Abstract: Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na+ to Cl− to l− excretion indicate that as thiazide administration or sodium chloride intake increases renal Na+ and Cl− excretion, l− reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled l−excretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced l−excretion rate as much as eight-fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131I by three- to eightfold, acutely. Within five to seven days after 131I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131I disappearance from plasma, reduced the fecal output of 131I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should therefore facilitate the safe excretion of 131I. This accelerated removal of 131I might be enhanced even more if thyroid uptake of 131I is blocked by administration of potassium iodide, as judged by the greater 131I recovery from thyroidectomized dogs.

Journal ArticleDOI
TL;DR: A highly significant decrease in iodine uptake by thyroid tissues in vitamin C deficient fish as compared to the controls, but the blood and other non-thyroid tissues recorded a significant increase in absorption and distribution of iodine.
Abstract: Using 131I as tracer, iodine uptake by various thyroid and non-thyroid tissues has been reported in Channa punctatus in which vitamin C deficiency was experimentally induced by feeding vitamin C deficient diet to a level when morphological deficiency syndromes appeared. This was compared with a parallel control, fed a complete diet. The study showed a highly significant decrease in iodine uptake by thyroid tissues in vitamin C deficient fish as compared to the controls. However, the blood and other non-thyroid tissues recorded a significant increase in absorption and distribution of iodine. These findings suggested hypofunctioning of thyroid gland due to a prolonged deficiency of vitamin C.



Journal ArticleDOI
TL;DR: Results suggest that the iodide-trapping defect in this man with goitrous hypothyroidism was due to an impairment in the specific iodide carrier system rather than in the Na+ -K+ -ATPase itself.
Abstract: A 32-yr-old man with goitrous hypothyroidism due to an iodide-trapping defect is described. He was admitted because of goiter which had been increasing in size. His parents were unrelated, and no cases of goiter were found in his family. On admission, serum T3 was 39 ng/dl, serum T4 was 1.0 micro g/dl, and serum TSH was 217 micro U/ml. His 24-h thyroidal 131 I uptake was 0.05%. Antithyroid antibodies were negative. In a tracer study, the thyroidal 131 I uptakes were 6.3% at 2 h, 4.0% at 6 h, and 0.9% at 24 h after iv injection of the radioiodide. The decline in the neck counts was linear and parallel to that in the serum 131 I. The 24-h urinary excretion of 131 I was 92%. The saliva to serum and gastric juice to serum ratios of 131 I concentrations at 2 h were very low (0.95 and 0.97, respectively). After the administration of iodine (14 mg in Lugol's solution/day for 10 days), serum T3 was 228 ng/dl, serum T4 was 6.8 micro g/dl, and serum TSH was 24 micro U/ml. Some biochemical studies were carried out using the patient's thyroid tissue. In a kinetic study on iodide trapping by thyroid slices, the thyroid to medium ratio of iodide concentration in the patient's tissue was constantly about 0.1, in contrast to 1.5-4.0 in a control subject. The microsomal peroxidase activity in the patient's thyroid, assessed by iodination of bovine serum albumin, was about 3-fold that in a control subject on the basis of DNA content. Both ouabain-sensitive and -insensitive thyroidal Na+ -K+ -ATPase activities were present. These results suggest that the iodide-trapping defect in this patient was due to an impairment in the specific iodide carrier system rather than in the Na+ -K+ -ATPase itself.

Journal ArticleDOI
TL;DR: Normal thyroid tissue showed no dependence of the T4/T3 ratio on the Tl, suggesting that thyroidal T3 and rT3 production is a random process.
Abstract: 20 Normal glands obtained from euthyroid subjects at autopsy were analysed for total iodine (Tl), PBl, L-thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), 3,3'-diiodothyronine (T2) after pronase hydrolysis. The mean Tl was 325.1+-47.2 micrograms/g wet tissue, giving a total iodine per gland of 10.01 mg. Pretreatment of iodine containing X-ray drugs in 8 patients did not significantly affect these results with the exception of Lipiodol. The mean T4, T3 and T2 values were 93.0+-23.1 micrograms/g, 5.25+-0.99 micrograms/g, 5.54+-1.05 micrograms/g and 0.60+-1.19 micrograms/g, respectively. In contrast to goitrous tissue, normal thyroid tissue showed no dependence of the T4/T3 ratio on the Tl. Compared with goitrous tissue PBI consisted of much more T4-l in normal tissue. The corresponding values were 47.7+-11.8% and 12.7+-3.4%, respectively. A positive relationship was found between Tl and T4, T3, rT3 but not with T2. The rT3 concentration corresponds to that of T3 in a remarkable way. The ratios of T3 or rT3 were similar, suggesting that thyroidal T3 and rT3 production is a random process. T2 represents only 0.73% of T4-l. Our results in normal thyroid tissue clearly show that the difference in iodine concentrations is only one factor among others in comparison to goitrous tissue.

Journal ArticleDOI
TL;DR: The retention of thyromimetic activity when alkyl groups replace the halogens in triiodothyronine requires a re-examination of the relationship between iodine and the thyroid hormones.

Journal ArticleDOI
TL;DR: In this article, the masking effect of potassium iodide with or without hydroxylamine on the interferences in the atomic-absorption spectrophotometric determination of antimony via its hydride by sodium borohydride tablet reduction has been studied.
Abstract: The masking effect of potassium iodide with or without hydroxylamine on the interferences in the atomic-absorption spectrophotometric determination of antimony via its hydride by sodium borohydride tablet reduction has been studied. It has been well known in the conventional colorimetric method [21] that both potassium iodide and stannous chloride completely suppress the evolution of stibine. However, in this sodium borohydride tablet reduction, potassium iodide plays a role in masking the interferences of not only stannous chloride but also other numerous ions. By the procedure established here, the calibration curve was linear up to a concentration of 0.04μg/ml of antimony with the coefficient of variation of 2.4 %. The method was successfully applied to the determination of antimony in a river sediment.