Topic
Iodine
About: Iodine is a research topic. Over the lifetime, 8936 publications have been published within this topic receiving 139981 citations. The topic is also known as: I & element 53.
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48 citations
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TL;DR: The method is rapid; four bromine and two iodine determinations can be done in one hour and can be detected down to 14 micrograms/dL and 2.23 mumol/L, respectively.
48 citations
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TL;DR: The data indicate that there is sufficient 3,5,3′-triiodothyronine in the “thyroxine” fraction of digests of thyroglobulin to account for the observed discrepancies between the biological activity of thyroid preparations and the quantity of thyroxine found in these preparations by the Blau method.
48 citations
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TL;DR: Relationships between I intake by lactating Holstein cows and iodine concentrations in milk and meat were investigated and moderate changes in dietary I are quickly reflected in milk I, but I in meat is relatively stable.
47 citations
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TL;DR: In this case, however, the amounts of iodide which enter the thyroid cell remain large, despite transport saturation and are replaced by diffused iodide, so this subject will not be discussed here.
Abstract: The many nonsubstrate effects of iodide in the thyroid appear to be due to at least four mechanisms: 1) a possible anion effect of iodide for which the supporting data are conflicting; 2) an inhibition of organic iodine formation (the so-called Wolff-Chaikoff effect); 3) the iodination of critical enzymes in the thyroid gland; and 4) the inhibition of cellular processes by iodinated products such as oxidized iodine itself, or an oxidation reaction involving iodine. The separation into these categories is not firm, but circumstantial evidence suggests that the mechanisms are different. In addition, high levels of iodide will saturate the iodide pump (Ki ≈3×10−5M) (1). In this case, however, the amounts of iodide which enter the thyroid cell remain large, despite transport saturation and are replaced by diffused iodide. Hence this subject will not be discussed here.
47 citations