Topic
Iodine
About: Iodine is a research topic. Over the lifetime, 8936 publications have been published within this topic receiving 139981 citations. The topic is also known as: I & element 53.
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46 citations
TL;DR: A one-pot dual functionalization of indoles has been developed that can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.
Abstract: A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation of indoles can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.
46 citations
TL;DR: To eliminate the constant attention required in the acid digestion procedures, Barker has recently introduced an alkaline ashing method with subsequent acid leaching of the iodine from the ash, and considerable simplification is thereby attained.
Abstract: THE relation of thyroid function to circulating iodine in the human appears to be well established (1–6) but the technical difficulties inherent in the determination of amounts of iodine of the order of 0.02 gamma have discouraged the universal adoption of existing methods (7, 8) as routine diagnostic aids. The methods most commonly used are based on Chaney's (9) procedure and involve acid digestion of the washed serum protein, reduction, distillation and absorption of the evolved iodine, and finally its colorimetric determination by its catalytic effect on the reduction of eerie sulfate by arsenious acid. To eliminate the constant attention required in the acid digestion procedures, Barker has recently introduced (10) an alkaline ashing method with subsequent acid leaching of the iodine from the ash. Considerable simplification is thereby attained, since no attention is required during the two to three-hour incineration period.
46 citations
TL;DR: When a large amount of iodine is ingested, the prevention of its deposition as organically bound compounds in the thyroid gland keeps the ingested iodine circulating as inorganic iodide, in which form it is readily excreted by the kidney.
Abstract: In an earlier communication (Wolff and Chaikoff, 1948) it was shown that the administration of large amounts of iodine temporarily inhibits the capacity of the normal thyroid gland to bind iodine organically. This inhibition appeared to be related to the level of plasma iodine. So long as the concentration of plasma iodine exceeded 20–35γ per cent, no organic binding of iodine occurred in the gland, and only when the concentration fell below this critical range did the gland resume its function of depositing iodine in an organic form. On the basis of these findings it was postulated that the level of plasma iodine is part of a homeostatic mechanism governing hormone synthesis in the normal gland. Thus, when a large amount of iodine is ingested, the prevention of its deposition as organically bound compounds in the thyroid gland keeps the ingested iodine circulating as inorganic iodide, in which form it is readily excreted by the kidney.
46 citations
TL;DR: Progressive iodination gives the same changes in distribution of peptide material among these iodopeptides as it does in iodine distribution, and the changes seen with iodination in vitro are similar to those occurring over time in vivo.
46 citations