Topic
Iodine
About: Iodine is a research topic. Over the lifetime, 8936 publications have been published within this topic receiving 139981 citations. The topic is also known as: I & element 53.
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TL;DR: It has been assumed without any evidence that ascorbic acid occurs only in traces except in the suprarenal cortex, and the iodine method has been used almost exclusively.
Abstract: MOST of the recorded measurements of the reduced glutathione content of tissues have been made by Tunnicliffe's method of titration with iodine on the assumption that the trichloracetic extracts of tissue contain little else but glutathione capable of reducing iodine in acid solution. A method depending upon a different principle was introduced by Mason, who found that the reduced glutathione content of liver, kidney and yeast extracts determined by titration against iodine is 120–200 per cent of the true value. His method has however been neglected, and the iodine method has been used almost exclusively. Recently, Bierich has evolved a third method for the estimation of reduced glutathione and has also obtained values much lower than those obtained by iodine titration. Ever since the discovery of ascorbic acid, it has been evident (as is mentioned by these workers) that where ascorbic acid occurs in the tissues, it will be estimated as glutathione in the iodine titration; but it has been assumed without any evidence that ascorbic acid occurs only in traces except in the suprarenal cortex.
43 citations
TL;DR: In this article, the IR spectra of polyamide 6 fibres treated with solutions of different concentrations of iodine and potassium iodide were studied and the spectral changes observed are related to variations in the polymorphic crystalline α and γ forms of the polyamide, which demonstrate the formation of a complex between the tri-iodide ion and the polymer during the iodine sorption process and a structural change during desorption.
43 citations
TL;DR: In this article, the influence of storage conditions on the stability of potassium iodide (KI) stability was evaluated by determining iodine retention during storage, and the results showed that the storage of iodised table salt resulted in iodine content decrease and the iodine losses in the salt tended to increase at high humidity or unlimited access of air.
Abstract: Summary
To determine the influence of storage conditions on potassium iodide (KI) stability, its traditional carrier – iodised table salt and alternative collagen carriers (i.e. iodinated collagen fibre and collagen hydrolysate) were stored at high (90%) and medium (60%) relative humidity of air. At medium humidity, these carriers were additionally stored at limited and unlimited access of air. The stability of KI was estimated by determining iodine retention during storage. The obtained results showed that the storage of iodised table salt resulted in iodine content decrease. The iodine losses in the salt tended to increase at high humidity or unlimited access of air. However, application of collagen preparations as carriers increased the KI stability, reducing iodine losses during storage and making them independent on the storage conditions.
43 citations
TL;DR: In man, when the serum inorganic iodide concentration exceeds 6 micrograms per 100 ml, there is partial inhibition of organic binding of iodine in the thyroid gland, and experiments suggest that iodine exerts its effect by slowing the rate of synthesis of thyroid hormone.
Abstract: The mechanism whereby the iodide ion beneficially affects the syndrome of hyperthyroidism remains unclear. Wolff and Chaikoff have shown that in the rat, elevation of the serum inorganic iodide concentration to approximately 30 micrograms per 100 ml. inhibits the synthesis of thyroid hormone (1). This effect, however, is transient. Stanley has presented evidence that in man, when the serum inorganic iodide concentration exceeds 6 micrograms per 100 ml. there is partial inhibition of organic binding of iodine in the thyroid gland (2). These experiments suggest that iodine exerts its effect by slowing the rate of synthesis of thyroid hormone. A different process by which iodide may affect hyperthyroidism is intimated by the in vitro studies of Albert and associates (3).
43 citations
TL;DR: Thyroidal, blood and urinary radioiodine studies suggest that fluorine inhibits the thyroid iodide-concentrating mechanism, and this may explain the therapeutic effect of prolonged administration of fluoride to patients with hyperthyroidism.
Abstract: Prolonged administration of a daily dose of 5-10 mg. of fluoride to patients with hyperthyroidism may cause clinical improvement together with a significant fall in the level of plasma protein-bound iodine and a reduction in the basal metabolic rate. Studies with radioactive fluorine failed to demonstrate any important accumulation of fluorine within the thyroid in vivo. Thyroidal, blood and urinary radioiodine studies suggest that fluorine inhibits the thyroid iodide-concentrating mechanism. Fluorine does not impair the capacity of the gland to synthesize thyroid hormone when there is an abundance of iodide in the blood. However, inhibition of the thyroidal concentrating capacity when the total iodide pool is low will impose a critical limitation of hormonal synthesis, and may explain the therapeutic effect.
43 citations