Topic
Iodine
About: Iodine is a research topic. Over the lifetime, 8936 publications have been published within this topic receiving 139981 citations. The topic is also known as: I & element 53.
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TL;DR: The thyrotropic activity of purified and commercial hCG is tested and its action with that of bovine TSH (bTSH) in cultured rat FRTL-5 cells in regard to stimulation of iodide uptake, activation of adenylate cyclase, and synthesis of DNA.
Abstract: hCG stimulates thyroid function, but it has been suggested that it is impurities in commercial hCG preparations or a variant of hCG that are responsible for the thyrotropic activity. In this study, we tested the thyrotropic activity of purified and commercial hCG and compared its action with that of bovine TSH (bTSH) in cultured rat FRTL-5 cells in regard to stimulation of iodide uptake, activation of adenylate cyclase, and synthesis of DNA. Iodide uptake was measured after incubation of the cells for 48–72 h with the test hormones, followed by a 40-min incubation with 0.1 μCi Na125I and 10 μmol/L carrier Nal; the 125I in the washed cells was counted. Adenylate cyclase was measured after incubation of the cells with the test stimulators for 3 h in hypotonic medium by RIA of cAMP in the medium. DNA synthesis was measured after incubation of the cells with the test substances for 24 h, followed by addition of [3H]thymidine for 3 h and then measuring the incorporation of [3H]thymidine into the cells. Both pu...
96 citations
TL;DR: It is concluded that calcium hydroxide should be given consideration for routine use as an intracanal agent in endodontics.
95 citations
TL;DR: Serum thyroglobulin concentration appears to be a good marker of iodine status, and even in a geographic area where mild iodine deficiency is common, a significant relation between iodine intake and thyroid volume was found.
95 citations
TL;DR: Ozone analyses with a modified potassium iodide absorbent (BKI: 0.1 M Na/sub 2/HPO/sub 4//0.1% KI) give results that increase with time and are 15 to 30% larger than those obtained by uv or BKI as discussed by the authors.
Abstract: Ozone analyses with a modified potassium iodide absorbent (BKI: 0.1 M H/sub 3/BO/sub 3//1% KI) give consistent agreement with uv photometry over the concentration range 0.1 to 3.5 ppM. The colorimetric iodine response with this BKI solution is both precise and stable. Trace reducing contaminants (ozone demand) in the potassium iodide reagents are a major problem in the work at 0.1 ppM. Iodometric analyses with NBKI (0.1 M Na/sub 2/HPO/sub 4//0.1 M KH/sub 2/PO/sub 4//1% KI) give results that increase with time and are 15 to 30% larger than those obtained by uv or BKI. These data are explained by the formation of a second product, P, in addition to iodine, when ozone is absorbed in NBKI and certain other buffered KI solutions; P slowly liberates additional iodine. At room temperature the kinetic rate of H/sub 2/O/sub 2/ + NBKI agrees with that of P + NBKI. Since other potential products have been excluded on this basis, P is tentatively identified as H/sub 2/O/sub 2/.
95 citations
TL;DR: Evidence has been presented to support the idea that iodine plays an important role in autoimmune thyroiditis, and several hypotheses have been proposed.
Abstract: Evidence has been presented to support the idea that iodine plays an important role in autoimmune thyroiditis. Excessive amounts induce thyroiditis in genetically susceptible animal strains, while intrathyroidal depletion of iodine prevents disease in strains susceptible to severe thyroiditis. While the mechanisms by which iodine promotes thyroiditis is unknown, several hypotheses have been proposed. (1) T and/or B cells may react specifically to iodinated portions of thyroglobulin (Tg) so that severe iodine depletion renders Tg non-immunogenic. (2) A defect in the iodine processing machinery in thyroid epithelial cells of a susceptible person or animal may, in the presence of iodine, result in elevated levels of oxygen or iodine radicals, which could damage membrane lipids or proteins. (3) Defective iodine processing may result in the iodination of lipid or proteins (other than Tg) which could act either as immunogens or polyclonal activators.
95 citations