Iodine

About: Iodine is a research topic. Over the lifetime, 8936 publications have been published within this topic receiving 139981 citations. The topic is also known as: I & element 53.

Subclinical hypothyroidism in Korean preterm infants associated with high levels of iodine in breast milk

Abstract: Context: The dietary iodine intake of lactating women has been reported to be high in Korea. Objectives: The aim of this study was to assess iodine balance and to determine its relationship with thyroid function in preterm infants. Design: Thyroid functions of preterm infants born at 34 wk gestation or less were evaluated in the first (n = 31) and third (n = 19) weeks. Mothers’ breast milk (BM) and random urine samples of infants were taken on the same days for thyroid function tests. Results: Iodine concentrations in BM were very high (198–8484 μg/liter), and one third of the infants had an iodine intake of more than 100 μg/kg per day at the third week after birth (excessive iodine intake group). At that time, the levels of TSH were positively correlated with urinary iodine (r = 0.622; P = 0.004). The frequencies of subclinical hypothyroidism were high in the excessive iodine intake group at the third and sixth weeks. The estimated daily iodine intake at the third week (51.2 ± 45.5 vs. 149.0 ± 103.8 μg/k...

The Accumulation of Radioactive Iodide by the Thyroid Gland in Normal and Thyrotoxic Subjects and the Effect of Thiocyanate on Its Discharge

Abstract: Interest in the effects of thiocyanate on the thyroid gland followed the observation that goiter occurred in 11 of 246 patients treated with the material for long periods of time for hypertension (Barker, 1936; Barker, Lindberg, and Wald, 1941). Both the thyroid enlargement and the accompanying manifestations of hypothyroidism were relieved by thyroid administration. It was later postulated that the action of thiocyanate in producing goiter in rats differed from that of the thiouracil derivatives (Astwood, 1943). With the former the thyroid effect was much slower to develop and was completely abolished by added iodide, which did not modify the thyroid response to compounds of the thiouracil series. From studies of the accumulation of I131 by surviving thyroid slices from sheep, Franklin, Chaikoff, and Lerner (1944) showed that the iodide-concentrating capacity was inhibited by thiocyanate. Other goitrogens did not significantly diminish the accumulation of iodide by the tissue but prevented its conversion...