Topic
Iridoid
About: Iridoid is a research topic. Over the lifetime, 1601 publications have been published within this topic receiving 31952 citations. The topic is also known as: iridoids & iridoid monoterpenoid.
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31 Dec 1998
Abstract: Preface. Acknowledgments. Introduction. Fatty acids. Acetylenic compounds in plants. Plant waxes. Polyketides. Benzoquinones. Naphthoquinones, and anthraquinones. Shikimic acid pathway. Phenylpropanoids. Coumarins. 2-pyrones, stilbenes, dihydrophenanthrenes, and xanthones. Flavonoids. Tannins. Non-protein amino acids. Peptides. Carbohydrates. Cyanogenic glycosides, and Cyanolipids. Glucosinolates. Introduction to terpenes. Monoterpenes. Iridoid monoterpenes. Sesquiterpenes. Diterpenes and sesterterpences. Triterpenes and steroids. Saponins and cardenolides. Limonoids, Quassinoids and related compounds. Tetraterpenes or cartenoids. Limonoids, quassinoids, and related compounds. Simple aimines, simple aromatic and pyridine alkaloids. Pyrrolidine, tropane, piperidine, and polyeketide alkaloids. Pyrrolizidine, quinolizidine and indolizidine alkaloids. Alkaloids derived from anthranilic acid. Isoquinoline and benzylisoquineoline alkaloids. Alkaloids derived from both tyrosine and phenylalanine. Indole alkaloids. Ergot and other indole alkaloids. Alkaloids of terpenoid orgin. Miscellaneous types of alkaloids.
633 citations
TL;DR: expression of the eight genes encoding this pathway, together with two genes boosting precursor formation and two downstream alkaloid biosynthesis genes, in an alternative plant host allows the heterologous production of the complex MIA strictosidine, which confirms the functionality of all enzymes of the pathway and highlights their utility for synthetic biology programmes.
Abstract: The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and vincristine, MIAs used as anticancer drugs, are produced by Catharanthus roseus in extremely low levels, leading to high market prices and poor availability. Their biotechnological production is hampered by the fragmentary knowledge of their biosynthesis. Here we report the discovery of the last four missing steps of the (seco)iridoid biosynthesis pathway. Expression of the eight genes encoding this pathway, together with two genes boosting precursor formation and two downstream alkaloid biosynthesis genes, in an alternative plant host, allows the heterologous production of the complex MIA strictosidine. This confirms the functionality of all enzymes of the pathway and highlights their utility for synthetic biology programmes towards a sustainable biotechnological production of valuable (seco)iridoids and alkaloids with pharmaceutical and agricultural applications.
363 citations
TL;DR: The discovery of iridoid synthase is reported, a plant-derived enzyme that generates the iridoids ring scaffold, as evidenced by biochemical assays, gene silencing, co-expression analysis and localization studies, and the prospects of using unrelated reductases to generate artificial cyclic scaffolds are highlighted.
Abstract: Iridoids are a large family of bicyclic natural products that possess anticancer, anti-inflammatory, antifungal and antibacterial activities; here the essential cyclization step in their biosynthesis is identified, opening up the possibility of production of naturally occurring and synthetic variants of iridoids for use in pharmacy or agriculture.
291 citations
TL;DR: Iridoid structures published for the first time during 1980-1989 are listed with available physical and spectral data: mp, [α]D, UV, 1 H nmr, 13 C nmr.
Abstract: Iridoid structures published for the first time during 1980-1989 are listed with available physical and spectral data: mp, [α]D, UV, 1 H nmr, 13 C nmr. Also included are revisions of iridoid structures originally published prior to 1980. The compounds are indexed alphabetically and by molecular weight, and a plant source index is also included
277 citations
227 citations