Showing papers on "Isopimpinellin published in 1992"
TL;DR: In this article, a chloroform extract of the roots of Angelica archangelica L. subsp. arangelica (Apiaceae) was used for the first time for the isolation of 15 coumarins from the root of the root.
Abstract: Fifteen coumarins, 2′-angeloyl-3′-isovaleryl vaginate (4), archangelicin (3), oxypeucedanin hydrate (8), bergapten (5), byakangelicin angelate (15), imperatorin (11), isoimperatorin (6), isopimpinellin (13), 8-[2-(3-methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen (12), osthol (1), ostruthol (9), oxypeucedanin (7), phellopterin (14), psoralen (2) and xanthotoxin (10), have been isolated from a chloroform extract of the roots of Angelica archangelica L. subsp. archangelica (Apiaceae). 2, 4, 12, and 15 are reported for the first time from A. archangelica L. The isolation was carried out using medium pressure liquid chromatography (MPLC) using the normal phase mode and then subsequently using a combination of the reversed and normal phase techniques. The eluents were optimized by thin layer chromatography and high performance liquid chromatography preassays according to the “PRISMA” system, and then transferred without modification of the solvent selectivity to preparative MPLC separations. The structures of the compounds were elucidated by a combination of spectroscopic methods. The isolation was carried out from a chloroform extract which in earlier tests had exhibited calcium blocking activity on the uptake of 45Ca2+ in clonal rat pituitary GH4C1 cells. The calcium antagonistic activity of the isolated compounds was then tested using the same method as for the extracts. All the coumarins tested exhibited calcium antagonistic activity. Archangelicin showed activity significantly higher than that of verapamil in this test system.
39 citations
TL;DR: Samples of isopimpinellin obtained by extraction of plants often contain small amounts of the active furocoumarin, 5‐methoxypsoralen, as an impurity, so the conflicting accounts of the photobiological activity of isopsin are probably related to this impurity.
Abstract: —
Pure isopimpinellin is photobiologically inactive. Samples of isopimpinellin obtained by extraction of plants often contain small amounts of the active furocoumarin, 5-methoxypsoralen, as an impurity. Thus the conflicting accounts of the photobiological activity of isopimpinellin are probably related to this impurity.
6 citations
TL;DR: The crude n-hexane and methanol extracts of the aerial parts of plant, Pimpinella monoica Dalz.
Abstract: The crude n-hexane and methanol extracts of the aerial parts of plant, Pimpinella monoica Dalz. (Umbelliferae) showed significant feeding deterrency to Spodopiera litura F. larvae. Phytochemical investigation of these extracts has resulted into the isolation of one furanocoumarin and five biogenetically related furanochromones. Furanocoumarin, isopimpinellin was found to be most active. Furochromones, visnagin and khellin exhibited significant activity while their hydroxymethyl analogues, khellol and ammiol showed moderate activity. α-Hydroxyisopropyldihydrofurochromone, visamminol was found to be least active.
1 citations