Topic
Isopimpinellin
About: Isopimpinellin is a research topic. Over the lifetime, 227 publications have been published within this topic receiving 4740 citations. The topic is also known as: 5,8-Dimethoxypsoralen & 5,8-Dimethoxypsoralene.
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TL;DR: The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages, human melanoma, and human breast cancer tumor cell lines, showing a major activity against the latter.
Abstract: The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.
25 citations
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TL;DR: The structure of the toxic plant-growth-inhibitor occurring in Thamnosma montana Torr and Frem was shown to be 5-(3′-methyl-2′,3′)-8-methoxypsoralen (I), largely by spectroscopic means as discussed by the authors.
25 citations
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TL;DR: The impact of functional groups on anti-larval settlement activities suggested that the groups on C-5′ and C-2′/C-3′ of isoamylene chian could affect the AF activities.
Abstract: In the search for new environmental friendly antifouling (AF) agents, four coumarins were isolated from the herbal plant Cnidium monnieri, known as osthole (1), imperatorin (2), isopimpinellin (3) and auraptenol (4). Furthermore, five coumarin derivatives, namely 8-epoxypentylcoumarin (5), meranzin hydrate (6), 2′-deoxymetranzin hydrate (7), 8-methylbutenalcoumarin (8), and micromarin-F (9) were synthesized from osthole. Compounds 1, 2, 4, 7 showed high inhibitory activities against larval settlement of Balanus albicostatus with EC50 values of 4.64, 3.39, 3.38, 4.67 μg mL−1. Compound 8 could significantly inhibit larval settlement of Bugula neritina with an EC50 value of 3.87 μg mL−1. The impact of functional groups on anti-larval settlement activities suggested that the groups on C-5′ and C-2′/C-3′ of isoamylene chian could affect the AF activities.
25 citations
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TL;DR: The mixture containing pimpinellin and its photodimerization product was effective against fourth instar larvae of Aedes aegypti, and a mixture of pimpinescent and swietenocoumarin B showed a LC50 value of 62.23 ppm.
Abstract: From a hexane fraction prepared from the roots of Esenbeckia grandiflora Mart, effective against fourth instar larvae of Aedes aegypti L (LC50 10823 ppm), eight coumarin derivatives [daphnetin 7-methyl-8-(3,3-dimethylallyl) ether, a mixture containing pimpinellin eight one of its photodimerization product, 5-senecioyl-xanthotoxin, 3-(1′,1′)-dimethylallylcolumbianetin, swietenocoumarin B, isopimpinellin, xanthotoxin, and 5-(1′-hydroxyisopentenyl)bergapten] were isolated in addition to sitosterol and sitostenone The mixture containing pimpinellin and its photodimerization product was effective against fourth instar larvae (LC50 at 4577 ppm), and a mixture of pimpinellin and swietenocoumarin B showed a LC50 value of 6223 ppm All isolated compounds were identified on the basis of the spectral data including 2D experiments Furthermore, previously unreported spectral data for some compounds are given
25 citations