Isopimpinellin

About: Isopimpinellin is a research topic. Over the lifetime, 227 publications have been published within this topic receiving 4740 citations. The topic is also known as: 5,8-Dimethoxypsoralen & 5,8-Dimethoxypsoralene.

Biological Activities of Indian Celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh

Abstract: In continuation of our work on Indian celery (Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOH–H2O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cytotoxicity to some yeast strains. Compound 1 also showed spasmolytic activity. On the other hand, isopimpinellin (3) and isorutarin (5) exhibited a spasmogenic effect on the smooth muscle preparations. Compound 5 was also found to have antioxidant activity. Among them, compound 4 was isolated for the first time from this plant. Copyright © 2011 John Wiley & Sons, Ltd.

A Reverse Phase Technique for Separating the Linearc Furano Coumarins in Celery

Abstract: A reverse phase method for separating the four linear furanocoumarins psoralen, xanthotoxin, bergapten, and isopimpinellin in celery is described. The photosensitizing compounds, psoralen, xanthotoxin, and bergapten were also quantified in celery blades and leaves. The method utilizes a phenyl-bonded HPLC column with a methanol-water solvent system. This system allows the use of a detection wavelength (225 nm) more appropriate for these linear furanocoumarins than is currently used with normal phase systems.

Simultaneous determination of furanocoumarins in infusions and decoctions from "Carapiá" (dorstenia species) by high-performance liquid chromatography.

Abstract: The use of furanocoumarins, which are photosensitizing compounds, combined with exposure to UV-A radiation is a common treatment for vitiligo, psoriasis, and a number of other skin diseases. Although furanocoumarins plus UV-A treatment is highly effective, several studies have shown that exposure to high doses increases the risk to development of cutaneus carcinoma. Several Dorstenia species are used in folk medicine, mainly against skin diseases, because of the presence of biologically active compounds. We present here analysis of the chemical composition of furanocoumarins from infusion and decoction of "Carapia" (Dorstenia species), which is used in Brazil against several diseases. We have employed high-performance liquid chromatography (HPLC) procedures for the quantitative determination of psoralen, bergapten, and isopimpinellin. The contents of furanocoumarins revealed an insignificant difference between infusion and decoction. Dorstenia tubicina and D. asaroides contained psoralen and bergapten only in the rhizomes, whereas D. vitifolia shows solely isopimpinellin in both rhizomes and aerial parts.

The fungitoxicities of cuticular and cellular components of citrus lime leaves

Abstract: SUMMARY Cuticular and cellular components of leaves of Citrus aurantifolia Swingle were tested for toxicity to Gloeosporium limetticola Clausen, responsible for the withertip disease. Cuticular waxes isolated from mature, resistant leaves showed little activity. A dimethoxy furocoumarin, isopimpinellin, isolated from the cellular components, was highly toxic, and ester and acidic fractions obtained from both young susceptible and mature resistant leaves showed some activity. The contents in the leaves and the toxicities in vitro of the active constituents suggest that they may contribute, to an important degree, to the defence of the leaf against G. limetticola.