Topic
Isopimpinellin
About: Isopimpinellin is a research topic. Over the lifetime, 227 publications have been published within this topic receiving 4740 citations. The topic is also known as: 5,8-Dimethoxypsoralen & 5,8-Dimethoxypsoralene.
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TL;DR: Wild parsnip-induced superficial necrotizing dermatitis was consistent with photodermatitis with no evidence of other allergic or inflammatory components and goats fed this wild Parsnip were largely unaffected.
18 citations
TL;DR: The developed method ensured good repeatability of corrected peak areas and migration times and good linearity of the relationship between the peak corrected area and the concentration of the compounds was observed and was successfully applied in the quantitative analysis of two different types of samples.
18 citations
TL;DR: In this paper, it was shown that carbon side-chain attachment precedes further oxygenation of umbelliferone in furanocoumarin biosynthesis, supporting the theory that it is a major intermediate in bergapten formation.
18 citations
TL;DR: In this paper, the antidiabetic and antioxidant activities of various extracts of roots of Heracleum persicum and isolation of ten furanocoumarin and a rare furano-marin-dimer type compounds through "bioassay guided fractionation" method were revealed.
Abstract: As a part of ongoing project on biological screening of about a hundred plant extracts from Iran, the significant inhibitory effect of n-hexane extract of roots of Heracleum persicum on α-glucosidase and its 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity were revealed. The present study was designed to evaluate the antidiabetic and antioxidant activities of various extracts of roots of Heracleum persicum and isolation of ten furanocoumarin and a rare furanocoumarin-dimer type compounds through “bioassay guided fractionation” method. The structures were elucidated by 1D and 2D NMR, EI-MS, and HRESI-MS data as psoralen (1), bergapten (2), xanthotoxin (3), isopimpinellin (4), angelicin (5), isobergapten (6), sphondin (7), pimpinellin (8), heratomin (9), 5-methoxyheratomin (10), moellendorffiline (11), and fraxetin (12). Moellendorffiline (11) with the IC50 value of 17.9 nM showed significant inhibitory activity against α-glucosidase, more potent than acarbose (IC50 = 23.5 nM) and also exhibited high antioxidant activity (IC50 = 0.2 μM), compared with butylated hydroxytoluene (IC50 = 0.1 μM).
18 citations
TL;DR: Pamburus missionis root contained imperatorin and 7-hydroxy-8-(3′,7′-dimethyl octa-2′,6′-dien)ylcoumarin and a new natural product, 3-(3-methyl-1-oxo-2-butenyl) 1H indole.
17 citations