Topic
Isopimpinellin
About: Isopimpinellin is a research topic. Over the lifetime, 227 publications have been published within this topic receiving 4740 citations. The topic is also known as: 5,8-Dimethoxypsoralen & 5,8-Dimethoxypsoralene.
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TL;DR: The presence of presence of phototoxic furanocoumarins would explain the occurrence of photodermatitis in the wearers of the leis.
Abstract: 5.7-dimethoxyeoumarin and isopimpinellin, together with the well-known phototoxic, photo-irritant furanocoumarins psoralen and 8-methoxypsoralen, were isolated and identified from leaves and fruits of pelea anisata H. Mann, a plant whose fruit arc used in the construction of mohikana leis used in parts of the Hawaiian Islands, The presence of presence of phototoxic furanocoumarins would explain the occurrence of photodermatitis in the wearers of the leis.
6 citations
TL;DR: Samples of isopimpinellin obtained by extraction of plants often contain small amounts of the active furocoumarin, 5‐methoxypsoralen, as an impurity, so the conflicting accounts of the photobiological activity of isopsin are probably related to this impurity.
Abstract: —
Pure isopimpinellin is photobiologically inactive. Samples of isopimpinellin obtained by extraction of plants often contain small amounts of the active furocoumarin, 5-methoxypsoralen, as an impurity. Thus the conflicting accounts of the photobiological activity of isopimpinellin are probably related to this impurity.
6 citations
Journal Article•
TL;DR: The ethereal extract from the crude ethanolic extract of Toddalia asiatica was chromatographed on silica gel and tested on biological activity and the active constituent was identified as isopimpinellin on the basis of chemical method and spectral analysis.
Abstract: The ethereal extract from the crude ethanolic extract of Toddalia asiatica was chromatographed on silica gel and tested on biological activity. A crystalline was obtained and confirmed as an active constituent in cardiovascular system. The active constituent was identified as isopimpinellin on the basis of chemical method and spectral analysis.
6 citations
TL;DR: The roots of Toona ciliata yielded four new 9,10-dihydrophenanthrenes which were identified on the basis of spectroscopic analysis as 9.10-Dihydro-9-hydroxy-9-(tert-butoxycarbonylmethyl)- 10-oxophenanthrene, 9.
Abstract: The roots of Toona ciliata yielded four new 9,10-dihydrophenanthrenes which were identified on the basis of spectroscopic analysis as 9,10-dihydro-9-hydroxy-9-(tert-butoxycarbonylmethyl)- 10-oxophenanthrene, 9,10-dihydro-9-hydroxy-9-(ethoxycarbonylmethyl)-10-oxophenanthrene, 9,10-dihydro-9-hydroxy-9-(n-butoxycarbonylmethyl)-10-oxophenanthrene and 9,10-dihydro-9- hydroxy-9-(benzyloxycarbonylmethyl)-10-oxophe-nanthrene. These compounds represent a novel group of phenanthrenes lacking oxygen in the benzene rings. In addition the known limonoid cedrelone, the sterols sitosterol and stigmasterol, the coumarins isopimpinellin and siderin, the furoquinoline alkaloid skimmianine and 2-hydroxy-4-methoxycinnamaldehyde were also isolated and characterized.
6 citations
TL;DR: Effects on chromosomes were studied in human lymphocytes IN VITRO as a result of treatment by isopimpinellin plus UV-A, which exhibited a weak clastogenic potency, which was expressed by an enhancement of the gap and break rates.
Abstract: Effects on chromosomes were studied in human lymphocytes IN VITRO as a result of treatment by isopimpinellin plus UV-A. Isopimpinellin was isolated from HERACLEUM SPHONDYLIUM with centrifugal accelerated layer chromatography (CLC). No induction of sister chromatid exchanges was found. Isopimpinellin plus UV-A exhibited, however, a weak clastogenic potency, which was expressed by an enhancement of the gap and break rates by a factor of 2 to 3. The relation between clastogenic and phototoxic activity of furocoumarins is critically discussed.
6 citations