Topic
Isopimpinellin
About: Isopimpinellin is a research topic. Over the lifetime, 227 publications have been published within this topic receiving 4740 citations. The topic is also known as: 5,8-Dimethoxypsoralen & 5,8-Dimethoxypsoralene.
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TL;DR: To investigate the difference in chemical constituents of Evodia species, eleven compounds were isolated with chromatography from 95% ethanol extract of the aboveground parts of E.vestia for the first time.
Abstract: To investigate the difference in chemical constituents of Evodia species,eleven compounds were isolated with chromatography from 95% ethanol extract of the aboveground parts of Evestia for the first timeOn the basis of spectral data,they were determined as bergapten(1),xanthotoxin(2),isopimpinellin(3),esculetin(4),scopoletin(5),skimmianine(6),confusameline(7),dictamine(8),marmesin(9),obacunone(10),and limonin(11)The important indole and indoloquinazolin alkaloids found in other species of Evodia were not obtained from this experiment
5 citations
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TL;DR: Osthol, imperatorin, isoimperatorin and marmesin have been isolated from Cneoridium dumosum (Nutt.) Hook as discussed by the authors.
5 citations
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TL;DR: In this article, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7 O-rutinoside, and 6-hydroxapigenin this article were isolated from the methanol extract of Malabaila suaveolens Coss.
Abstract: Volatile oil components, fatty acids, β-amyrin, and sterols were identified in the n -hexane extract of Malabaila suaveolens Coss. fruits. Angelicin, 4,7,9-trimethyl psoralen, isopimpinellin and umbelliferone were isolated from the dichloromethane extract of the plant. 5-Hydroxy 7, 3`, 4`-trimethoxyflavone, apigenin and its 7-O0-β-D-glucopyranoside were isolated from the ethyl acetate extract. From the methanol extract, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7-O-rutinoside, and 6-hydroxyapigenin 7-O-β-D-glucopyranoside were isolated. Toxicity study of n-hexane, dichloromethane, ethyl acetate extract and methanolic extracts of the plant proved that it is relatively nontoxic. The tested extracts showed significant analgesic and anti-inflammatory effects as compared with control groups and reference drugs. Also, the tested extracts showed significant antioxidant activity as compared with reference.
5 citations
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TL;DR: The chemical constituents in the roots of Angelica nitida are investigated for the first time by silica gel and spectral analysis.
Abstract: OBJECTIVE To investigate the chemical constituents in the roots of Angelica nitida. METHODS The chemical constituents were isolated by silica gel,their structures were identified by spectral analysis. RESULTS Nine compounds were isolated and identified as isoimperatorin(I), imperatorin(II), cnidilin(III), beta-sitosterol(IV), isopimpinellin(V), phellopterin(VI), neobyakangelicol(VII), (3S)-2,2-dimethyl-3,5-dihydroxy-8-hydroxylmethyl-3,4-dihydro-2H,6H-benzo[1,2-b: 5,4-b'] dipyran-6-one(VIll) and byakangelicin (IX). CONCLUSION All the compounds are isolated from the plant for the first time.
5 citations
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TL;DR: The data suggest that Peucedanum zenkeri seed extract contains antibacterial agents which are active against Salmonella species causing typhoid and paratyphoid fevers, and some bacteria strains causing urogenital infections.
Abstract: Objective: In a search for natural substances with potential for the treatment of typhoid fevers and urogenital infections, the methylene chloride extract of the seeds of Peucedanum zenkeri was investigated. Methodology: The extract was subjected to column chromatography leading to the isolation of seven compounds. Their structures were determined using modern 2D NMR techniques and by comparison with published NMR data. These compounds were tested against Salmonella typhi, Salmonella paratyphi B, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus, using both agar diffusion and broth dilution techniques. Results: The compounds isolated were umbelliprenin (1), prangenin (2), imperatorin (3), isopimpinellin (4), bergapten (5), cnidilin (6) and stigmasterol (7). Among the above seven compounds, only two (1 and 2) exhibited antibacterial activity. For compound 1, the MIC value was 300 µg/ml against P. aeruginosa, S. aureus, S. typhi and S. paratyphi B. For compound 2, the MIC values varied between 200 and 300 µg/ml against all the bacteria strains tested. Conclusion: These data suggest that Peucedanum zenkeri seed extract contains antibacterial agents which are active against Salmonella species causing typhoid and paratyphoid fevers, and some bacteria strains causing urogenital infections. The antibacterial activity of compound 2 appears to be due to the epoxide group present in its structure.
5 citations