Topic
Isopimpinellin
About: Isopimpinellin is a research topic. Over the lifetime, 227 publications have been published within this topic receiving 4740 citations. The topic is also known as: 5,8-Dimethoxypsoralen & 5,8-Dimethoxypsoralene.
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TL;DR: The present study indicated that the combination of in vitro tyrosinase inhibition assay coupled with UPLC-MS/MS could be widely applied to the rapid screening of active substances from various natural resources.
Abstract: In this study, an in vitro tyrosinase inhibition assay in combination with ultra performance liquid chromatography-orbitrap mass spectrometry (UPLC-orbitrap-MS) was developed for the rapid screening and identification of tyrosinase modulators from roots of Angelica keiskei. Of the 15 candidates considered, nine chalcones, xanthoangelols (1), B (2), D (3), E (4), G (5), H (6), 4-hydroxyderricin (7), xanthokeismin B (8) and (2E)-1-[4-hydroxy-2-(2-hydroxy-2-propanyl)-2,3-dihydro-1-benzofuran-7-yl]-3-(4-hydroxyphenyl)-2-propen-1-one (9), five coumarins, umbelliferone (10), selinidin (11), isopimpinellin (12), phellopterin (13) and xanthyletin (14), and one other compound, ashitabaol A (15), were distinguished between the test samples and the controls with statistical significance, and the structure of each compound was determined by comparing with in-house standards and the literature. Among these, six compounds, xanthoangelol (1), xanthoangelol D (3), xanthoangelol H (6), 4-hydroxyderricin (7), laserpitin (16) and isolaserpitin (17), were isolated from roots of A. keiskei. Of the compounds isolated, compounds 1, 7 and 16 were subjected to tyrosinase inhibitory assay, and the IC50 values were 15.87 ± 1.21, 60.14 ± 2.29 and >100 μM, respectively. The present study indicated that the combination of in vitro tyrosinase inhibition assay coupled with UPLC-MS/MS could be widely applied to the rapid screening of active substances from various natural resources.
4 citations
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TL;DR: Compounds 1,4, and 5 are isolated from the plants in Peucedanum L. for the first time, and compounds 2,3,6-10, and 12 are firstly isolated from P.decursivum.
Abstract: Objective To investigate the chemical constituents from Peucedanum decursivum.Methods P.decursivum was extracted with 95% ethanol,the compounds were isolated via various chromatographic methods,and their structures were identified by detailed spectroscopic analyses.Results Twelve compounds were isolated from the acetic ether fraction in the 95% extract of P.decursivum and were identified as isobergapten(1),bergapten(2),pimpinellin(3),isopimpinellin(4),columbianetin acetate(5),sphondin(6),qianhucoumarin E(7),xanthotoxin(8),osthole(9),ferulic acid(10),β-sitosterol(11),and psoralen(12).Conclusion Compounds 1,4,and 5 are isolated from the plants in Peucedanum L.for the first time,and compounds 2,3,6-10,and 12 are firstly isolated from P.decursivum.
4 citations
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TL;DR: In this article, the chemical constituents from the root bark of Changium smyrnioides were identified by various kinds of column chromatographies on silica gel, Sephadex LH-20, and recycling preparative HPLC.
Abstract: Objective To study the chemical constituents from the root bark of Changium smyrnioides. Methods Compounds were isolated by various kinds of column chromatographies on silica gel, Sephadex LH-20, and recycling preparative HPLC from the ethanol extract in the root bark of C. smyrnioides, and their structures were elucidated by the physicochemical characteristics and spectral analyses. Results Fifteen chemical constituents were obtained and identified as imperatorin(1), phellopterin(2), xanthotoxol(3), 5-hydroxy-8-methoxy-psoralen(4), vanillic acid(5), alloimperatorin(6), psoralen(7), bergapten(8), 8-O-β-D-glucopyranosyl-5-methoxylpsoralen(9), isopimpinellin(10), caffeic acid(11), aurantiamide acetate(12), vaginatin(13), β-sitosterol(14), and succinic acid(15). Conclusion Compounds 6—13 are isolated from the plants in Changium Wolff for the first time.
4 citations
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TL;DR: In this article, the chemical constituents of Saussurea involucrate Kar. et al. were isolated by column chromatography, and their structures were elucidated by chemical and spectroscopy evidences.
Abstract: OBJECTIVE To study the chemical constituents of Saussurea involucrate Kar. et Kir. METHODS The chemical constituents were isolated by column chromatography, and their structures were elucidated by chemical and spectroscopy evidences. RESULTS Eight coumarin compounds were isolated and identified as osthol, bergapten, isopimpinellin, edultin, vaginidiol diacetate, alloisoimperatorin, oroselol, xanthotoxol, respectively. CONCLUSION The eight coumarin compounds are isolated from Saussurea involucrate Kar. et Kir. for the first time.
3 citations
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TL;DR: In this paper, simple and fast HPLC methods in one-dimensional and two-dimensional dimensions were developed for the simultaneous analysis of the 15 most common furocoumarins reported in Citrus essential oils.
Abstract: The concentration of furocoumarins, known to induce mutagenesis, carcinogenesis and photodermatitis under UV radiation, is limited by the EU cosmetic regulation in consumer products such as cosmetics, sun protection and bronzing formulations. The bergapten concentration is also limited by the International Fragrance Association. Analytical methods have been proposed for their quantification using high-performance liquid chromatography (HPLC) coupled with UV detection or mass spectrometry with limits of detection (LOD) and quantification (LOQ) in accordance with the regulation. These methods are time and solvent consuming for routine quality control analyses. In this context, simple and fast HPLC methods in one- (1-D) and two- (2-D) dimensions were developed for the simultaneous analysis of the 15 most common furocoumarins reported in Citrus essential oils: psoralen, bergapten, xanthotoxin, isopimpinellin, oxypeucedanin, oxypeucedanin hydrate, byakangelicol, byakangelicin, heraclenin, 8-geranyloxypsoralen, bergamottin, imperatorin, isoimperatorin, phellopterin, epoxybergamottin along with five other furocoumarins known to be present in Angelica, bergamot or Heracleum species: angelicin, bergaptol, isobergapten, psora-4 and 5-(4-phenoxybutoxy)psoralen. The 1-D method was validated for the quantification of bergapten using a Camag TLC Scanner as a detector. The LOD was determined at 2 mg/kg. The method was linear from 2 to 100 mg/kg and the method range was defined using accuracy profiles at with an 80% tolerance interval, with a 30% error, to be 5–100 mg/kg in acetonitrile and 13–100 mg/kg in matrix.
3 citations