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Showing papers on "Isopropyl alcohol published in 1982"


Journal ArticleDOI
TL;DR: Results indicate that mixed alcohol poisoning with ethanol and isopropanol suggests decreased production of acetone, the major metabolite of isoproanol, to death.
Abstract: A population of persons who were found, at death, to have significant levels of isopropyl alcohol (isopropanol) in their blood is described. The role of isopropanol in causing death is reviewed in 57 fatal cases. The contribution of acetone, the major metabolite of isopropanol, to death is assessed. Results indicate that mixed alcohol poisoning with ethanol and isopropanol suggests decreased production of acetone. Modalities for antemortem and postmortem detection of isopropanol are presented.

37 citations


Journal ArticleDOI
TL;DR: It is believed that all true disulfiram-alcohol reactions are systemic, rather than local, in nature and require a substantial amount of alcohol to enter the system.
Abstract: • Cutaneous reactions to ethyl alcohol (ethanol), N-propyl alcohol (1-propanol), isopropyl alcohol (2-propanol), and acetaldehyde were evaluated in a control group and in patients before and while they were receiving disulfiram therapy Local cutaneous erythema was observed from patch tests with ethyl alcohol, N-propyl alcohol, and isopropyl alcohol in hydrated skin, and from acetaldehyde in dry skin Since reactions noted from topically applied alcohols before and while the patients were receiving disulfiram therapy were not statistically different, a localized disulfiram-alcohol reaction is unlikely Erythema resulting from topically applied alcohols occurred in a dose-related manner and was caused by a direct vasodilatory effect on the cutaneous microvasculature We believe that all true disulfiram-alcohol reactions are systemic, rather than local, in nature and require a substantial amount of alcohol to enter the system ( Arch Dermatol 1982;118:157-159)

33 citations


Journal ArticleDOI
TL;DR: A comatose and hypotensive patient was successfully treated with hemodialysis after ingesting 480 mL of isopropyl alcohol and its major metabolite acetone and a comparison was made of urine excretion to dialysis removal of these compounds to compare their respective efficacy.
Abstract: A comatose and hypotensive patient was successfully treated with hemodialysis after ingesting 480 mL of isopropyl alcohol. Removal of isopropyl alcohol and its major metabolite acetone was measured in urine, blood, and dialysate. According to dialysate measurements, approximately 19 g of isopropyl alcohol and 7 g of acetone were removed per hour using a standard 1 m2 dialyzer. The average dialysance of isopropyl alcohol and acetone were 137 and 165 mL/min, respectively. Removal of isopropyl alcohol was 52 times and acetone 40 times more efficient through hemodialysis than through urinary excretion. Since coma and hypotension portend a bad prognosis and since urinary excretion is slow relative to hemodialysis removal, hemodialysis may be considered life-saving in patients comatose from isopropyl alcohol poisoning. There have been two previous reports of hemodialysis used for treatment of isopropyl alcohol intoxication [1, 2]. Neither of these reports describes the kinetics of isopropyl alcohol removal. This paper reports a third patient treated with hemodialysis who afforded us the opportunity to study blood, urine, and dialysate levels of isopropyl alcohol and its chief metabolite, acetone. By utilizing these results a comparison was made of urine excretion to dialysis removal of these compounds to compare their respective efficacy. In addition, the estimated removal by dialysance calculations was compared to estimated removal by measurement of dialysate volumes and concentrations.

28 citations


Journal ArticleDOI
TL;DR: In this article, the decomposition of isopropyl alcohol was carried out on the solid solution system MgAI2−xFexO4 (x = 0 to 2) and the system exhibited both dehydrogenation and dehydration activities.

23 citations


Journal ArticleDOI
TL;DR: In this article, tetramethylethylene was ozonized at 0 °C in several binary protic solvents and the relative reactivities toward acetone carbonyl oxide were measured.
Abstract: Tetramethylethylene was ozonized at 0 °C in several binary protic solvents and the relative reactivities of the solvents toward acetone carbonyl oxide were measured. The reactivity was found to decrease in the order methanol, ethanol, propyl alcohol, isopropyl alcohol, water, t-butyl alcohol, and acetic acid.

18 citations


Patent
27 Sep 1982
TL;DR: In this paper, a stable pituitous bicarbonate suspension in an aqueous/alcoholic medium having a high alcohol content and a low water content, with substantially no bicrate in solution, containing hydroxyethyl cellulose as the essential suspending agent, was presented.
Abstract: A novel stable pituitous bicarbonate suspension in an aqueous/alcoholic medium having a high alcohol content and a low water content, with substantially no bicarbonate in solution, containing hydroxyethyl cellulose as the essential suspending agent, said alcohol content exceeding the upper solubility of hydroxyethyl cellulose in said alcohol and the water content being sufficient to prevent precipitation of said suspending agent and at least 5% by weight; having utility in deodorant products such as roll-ons, pumps and on substrates such as deodorant pads. The concentration of sodium or potassium bicarbonate is preferably high, about 10%, however 1-20% may be used. The alcohol utilized herein is monohydric such as ethanol, methyl or isopropyl alcohol, however, a polyhydric alcohol such as propylene glycol, glycerine and/or polypropylene glycols may be partially substituted for the monohydric alcohol. The bicarbonate suspensions have been found to be less irritating to the body and dry faster than the bicarbonate solutions because the bicarbonate is delivered as a powder to be activated by body moisture.

16 citations


Patent
20 Sep 1982
TL;DR: Vinylpyrrolidone and vinyl acetate monomers are polymerized using free radical initiator consisting of t-Butylperoxypivalate and preferably in solvent consisting essentially of water, isopropyl alcohol, sec. butyl alcohol or mixtures thereof.
Abstract: Vinylpyrrolidone and vinyl acetate monomers are polymerized using free radical initiator consisting of t-Butylperoxypivalate and preferably in solvent consisting essentially of water, isopropyl alcohol, sec. butyl alcohol or mixtures thereof to produce vinyl pyrrolidone/vinyl acetate copolymer.

15 citations


Patent
27 Aug 1982
TL;DR: In this article, a water-isopropyl alcohol mixed soln was used to give a porcelain capacitor with a high dielectric strength of ≥150V when the film thickness is restricted to 10μm.
Abstract: PURPOSE: To manufacture dielectric powder giving a dense thick film porcelain capacitor almost free from defects by dropping a water-isopropyl alcohol mixed soln. into a soln. of specified 3 kinds of metallic alkoxides in isopropyl alcohol. CONSTITUTION: To isopropyl alcohol are added 48.50W49.92mol% barium dialkoxide, 45.5W49.78mol% titanium tetraalkoxide and 0.3W6mol% tantalum pentaalkoxide. The amount of the isopropyl alcohol is ≥5 times the total amount of the alkoxides by weight. They are stirred at 40W85°C to dissolve the alkoxides. The resulting soln. is kept at 40W85°C, a water-isopropyl alcohol mixed soln. having 1:10W2:1 weight ratio is dropped into said soln. under stirring, and Ta doped BaTiO 3 is precipitated by aging at 40W85°C. The precipitate is separated by filtration, dried, and heated to 400W1,000°C to obtain dielectric powder having ≥1,500 dielectric constant at room temp. and giving a small-sized thick film porcelain capacitor of a large capacity. The dielectric strength of the capacitor is ≥150V when the film thickness is regulated to 10μm. COPYRIGHT: (C)1984,JPO&Japio

15 citations


Journal ArticleDOI
TL;DR: This is the first case of isopropyl alcohol ingestion in which "pseudo" renal failure has been described, and the patient had a spurious elevation of serum creatinine caused by the high acetone level.
Abstract: We have described a case of isopropyl alcohol intoxication with the confusing picture of normoglycemia and ketonuria, without evidence of metabolic acidosis. The patient also had a spurious elevation of serum creatinine caused by the high acetone level. The positive ketone test was secondary to high levels of acetone, the main metabolic product of isopropyl alcohol. This is the first case of isopropyl alcohol ingestion in which "pseudo" renal failure has been described.

15 citations


Patent
28 Apr 1982
TL;DR: In this paper, a process for producing isopropyl alcohol and tert-butyl ether from a mixture of light hydrocarbons containing propane and butane is described.
Abstract: A process for producing isopropyl alcohol and isopropyl tert-butyl ether from a mixture of light hydrocarbons containing propane and butane, comprises: (a) separating from the mixture of light hydrocarbons a propane fraction and a butane fraction containing at least n-butane; (b) isomerizing at least a portion of the n-butane in the butane fraction from step (a) whereby a hydrocarbon mixture containing at least n-butane and isobutane is formed; (c) catalytically dehydrogenating the isobutane in the hydrocarbon mixture from step (b) whereby a hydrocarbon mixture containing at least isobutene is produced; (d) catalytically dehydrogenating the propane in the propane fraction from step (a) whereby a hydrocarbon mixture containing at least propene is produced; (e) reacting the propene in the hydrocarbon mixture from step (d) with water, whereby a mixture containing hydrocarbons and isopropyl alcohol is formed; (f) reacting the isopropyl alcohol from step (e) with at least part of the isobutene in the hydrocarbon mixture from step (c) whereby a mixture containing hydrocarbons and isopropyl tert-butyl ether is formed; (g) recycling the hydrocarbons in the hydrocarbon mixture from step (e) to step (d), respectively; (h) recycling the hydrocarbons in the hydrocarbon mixture from step (f) to step (c); and (i) recovering at least the isopropyl tert-butyl ether.

14 citations


Patent
20 Sep 1982
TL;DR: Vinylpyrrolidone is polymerized using free radical initiator consisting essentially of t-Butylperoxypivalate and preferably in solvent consisting essentially, water, isopropyl alcohol, sec. butyl alcohol or mixtures thereof as mentioned in this paper.
Abstract: Vinylpyrrolidone is polymerized using free radical initiator consisting essentially of t-Butylperoxypivalate and preferably in solvent consisting essentially of water, isopropyl alcohol, sec. butyl alcohol or mixtures thereof.

Journal ArticleDOI
TL;DR: In this paper, the reaction mechanism has been simulated in detail, and in conjunction with results obtained earlier for the overall self-reaction of isopropylperoxy radicals, the following rate data have been obtained for the reactions 2(CH3)2CHO2·→(CH 3)2CHOH + (CH3]2CO + O2(3a), 2( CH3) 2CHO·+ O(3b)k3b/k3a increases with temperature, from 1.39 ± 0.04 at 302 K to 1
Abstract: The principal products of the photo-oxidation of trans-2,2′-azopropane between 333 and 373 K are acetone, isopropyl alcohol, isopropyl hydroperoxide, acetaldehyde, formaldehyde, methyl alcohol and cis-2,2′-azopropane. The reaction mechanism has been simulated in detail, and, in conjunction with results obtained earlier for the overall self-reaction of isopropylperoxy radicals, the following rate data have been obtained for the reactions 2(CH3)2CHO2·→(CH3)2CHOH +(CH3)2CO + O2(3a), 2(CH3)2CHO2·→ 2(CH3)2CHO·+ O2(3b)k3b/k3a increases with temperature, from 1.39 ± 0.04 at 302 K to 1.83 ± 0.04 at 333 K and 2.80 ± 0.08 at 373 K. Values of A3a and A3b of 2.44 ± 0.31 × 107 and 1.38 ± 0.26 × 109 dm3 mol–1 s–1 and E3a and E3b of 12.0 ± 1.0 and 21.3 ± 1.5 kJ mol–1 were determined.

Journal ArticleDOI
TL;DR: The effect of added sodium alkoxides on the position of the hydroxy proton resonance of the respective alcohols has been measured for ethanol, isopropyl alcohol, and t-butyl alcohol as mentioned in this paper.
Abstract: The effect of added sodium alkoxides on the position of the hydroxy proton resonance of the respective alcohols has been measured for ethanol, isopropyl alcohol, and t-butyl alcohol. Corresponding measurements have also been performed for solutions in hydroxy-deuteriated alcohols containing only a small fraction of the hydroxy-protiated alcohol. Analysis of the data leads to the conclusions (1) that for all three alcohols the deuterium fractionation factor (measuring the isotopic discrimination between bulk solvent molecules and solvent molecules hydrogen-bonded to alkoxide ions) has a value (ca. 0.75) close to that in the previously studied sodium methoxide–methanol system, (2) that the average number of solvent molecules hydrogen-bonded to alkoxide ions decreases down the series, from 3 for methanol to ca. 1.6 for t-butyl alcohol, which is consistent with the parallel increase in basicity of the solutions, (3) that the effect of sodium perchlorate, unlike that of sodium alkoxides, on the position of the hydroxyproton resonance is essentially the same in all solvents, and (4) that hydroxy-deuteriation of the solvent appears to lead in all cases to a small upfield shift of the resonance of the residual hydroxylic protium.

Journal ArticleDOI
TL;DR: In this article, the effect of solvent structure on the first-order solvolysis of the trans-dichlorotetrapyridinecobalt(III) ion, rates have been measured in.
Abstract: To investigate the effect of solvent structure on the first-order solvolysis of the trans-dichlorotetrapyridinecobalt(III) ion, rates have been measured in.mixtures of water with isopropyl alcohol as the physical properties of these mixtures show that the addition of isopropyl alcohol to water in water-rich conditions is very effective in inducing the formation of structure in the solvent. A linear plot of log (rate constant) against the Grunwald–Winstein Y factor confirms that the solvolysis is an SN1-type process with considerable extension of the metal-chloride bond in the transition state. A non-linear plot of log (rate constant) against reciprocal of the dielectric constant shows that changes in solvent structure with composition are important in determining the variation of rate constant and this is confirmed by the observation of a maximum in the variation of both the enthalpy and entropy of activation in the region where the physical properties of the mixture indicate a maximum in the structure formation. The application of a free-energy cycle shows that the effect of structure is greater in the transition state than in the initial state.

Patent
04 Nov 1982
TL;DR: In this paper, the authors used a dilute aqueous solution of a specific heteropoly-acid as a catalyst, and made contact with a ≤ 4C olefin such as propylene at 180W350°C and 100W500kg/cm 2 pressure.
Abstract: PURPOSE: To prepare an alcohol suppressing the corrosion of the apparatus, in high yield, by using a dilute aqueous solution of a specific heteropoly-acid as a catalyst, and contacting the solution with an olefin at high temperature and pressure to effect the direct hydration of the olefin CONSTITUTION: An aqueous solution containing 01W10g/l, preferably 05W5g/l of a compound selected from phosphomolybdotungstic acid, phosphovanadotungstic acid and phosphomanganotungstic acid of formula (Me is Mo, V or Mn) and their soluble salts, is adjusted and maintained to 20W45pH, and made to contact with a ≤4C olefin such as propylene at 180W350°C and 100W500kg/cm 2 pressure to obtain an alcohol such as isopropyl alcohol The control of the pH of the catalyst solution can be carried out by adding a soluble basic substance which does not decompose the catalyst component nor produce inert substance, eg NaOH, CaO, etc EFFECT: Ordinary stainless steel can be used as the material of the reaction apparatus, and it is expected to prevent the lowering of the catalytic activity caused by corrosion COPYRIGHT: (C)1984,JPO&Japio


Patent
19 May 1982
TL;DR: In this paper, an improved process for indirect hydration of propylene to form di-isopropyl ether and isoprophyl alcohol is provided, in which propylene is absorbed in sulfuric acid to form an extract which is withdrawn from the absorbing zone; water in carefully controlled amounts is admixed with the extract and the resulting mixture is passed to an ether generating zone to form a vaporous ether product and a bottoms product depleted in di-isoopric ether and containing sulfuric acids in a concentration at least equal to the acid concentration in the extract withdrawn
Abstract: An improved process for indirect hydration of propylene to form di-isopropyl ether and isopropyl alcohol is provided in which propylene is absorbed in sulfuric acid to form an extract which is withdrawn from the absorbing zone; water in carefully controlled amounts is admixed with the extract and the resulting mixture is passed to an ether generating zone to form a vaporous ether product and a bottoms product depleted in di-isopropyl ether and containing sulfuric acid in a concentration at least equal to the acid concentration in the extract withdrawn from the absorbing zone The withdrawn bottoms is then divided into two portions: a first portion is recycled to the absorber; and the second such portion is admixed with sufficient water to hydrate absorbed olefin values and the resulting mixture is fed to an alcohol generator for formation of isopropyl alcohol as overhead product and dilute sulfuric acid as bottoms product

Patent
09 Dec 1982
TL;DR: Isopropyl alcohol is dehydrogenated to acetone by contact with a catalyst having improved selectivity and activity which comprises a mixture of copper, zinc and chromium supported on an alpha alumina carrier.
Abstract: Isopropyl alcohol is dehydrogenated to acetone by contact with a catalyst having improved selectivity and activity which comprises a mixture of copper, zinc and chromium supported on an alpha alumina carrier.

Patent
30 Jan 1982
TL;DR: In this article, the authors proposed a method to obtain a titled substance, useful as a viscosity increasing agent for coating materials, and capable of giving an aqueous solution of good transparency at a low cost, by dispersing an alkali cellulose in isopropyl alcohol, etc., heating the dispersion at a temperature to advance the reaction sufficiently, and reacting with sodium beta-chloroethanesulfonate under agitation.
Abstract: PURPOSE:To obtain the titled substance, useful as a viscosity increasing agent for coating materials, and capable of giving an aqueous solution of good transparency at a low cost, by dispersing an alkali cellulose in isopropyl alcohol, etc., heating the dispersion at a temperature to advance the reaction sufficiently, and reacting the dispersion with sodium beta-chloroethanesulfonate under agitation. CONSTITUTION:A dried cellulose, e.g. powdered linter pulp, is dispersed in isopropyl alcohol, etc. in a reactor, and aqueous solution of sodium hydroxide is added and agitated to give an alkali cellulose dispersion. The resultant dispersion is then heated to a temperature enough to advance the reaction, and sodium beta-chloroethanesulfonate is added to the dispersion continuously or in portions with agitation while refluxing the dispersing medium to carry out the reaction. After the completion of the reaction, excess sodium hydroxide is neutralized with acetic acid, etc., and the reaction product is filtered. The separated solid is then washed with hydrous methanol to afford the aimed substance.

Journal ArticleDOI
TL;DR: Column chromatographic procedures have been developed for separating binary mixtures of commercial DDBS with the hydrotropes sodiumm-xylenesulfonate (SXS) and 8-[5(6)-carboxy-4-hexyl-cyclohex-2-enyl] octanoic acid (DAC).
Abstract: Column chromatographic procedures have been developed for separating binary mixtures of commercial sodium dodecylbenzenesulfonate (DDBS) with the hydrotropes sodiumm-xylenesulfonate (SXS) and 8-[5(6)-carboxy-4-hexyl-cyclohex-2-enyl] octanoic acid (DAC) and ternary mixtures of these three materials. The materials are separated on a specially purified silica gel column. The C21 dicarboxylic acid (DAC) is eluted with 2:3 (v/v) chloroform/acetone in the presence of SXS, with 3:2 (v/v) chloroform/acetone in its absence. The DDBS is eluted with 1:9 (v/v) isopropyl alcohol/acetone in the presence of SXS, with methanol in its absence. The SXS is eluted with methanol in the presence of DAC, with 8:2 (v/v) isopropyl alcohol/acetone in its absence. The presence of SXS in mixtures with DDBS in greater than equimolar amounts interferes with the Hyamine 1622, mixed indicator titration for DDBS.

Patent
27 Apr 1982
TL;DR: In this article, the authors describe a mixture of isopropyl tert-butyl ether and sec. butyl tertbutyl butyl ether containing from a propane and butane mixture of hydrocarbons produced by separation of a butane fraction, the isomerization of a portion of the n-butane, catalytically dehydrogenating butane and propane, reacting the propene and nbutenes and butadiene by hydrogenation of the recovered from butene-2
Abstract: Gemische von Isopropyl-tert.-butylether und sec.--Butyl-tert.-butylether werden aus einem Propan und Butan enthaltenden Kohlenwasserstoffgemisch hergestellt durch Abtrennung einer Propan- und einer Butanfraktion, Isomerisierung eines Teiles des n-Butans, katalytische Dehydrierung von Butan und Propan, Umsetzen des Propen sowie der n-Butene und des aus Butadien durch Hydrierung gewonnenen Buten-2 mit Wasser zu Isopropylalkohol sowie sec.-Butylalkohol und deren Umsetzung mit Isobuten zu Isopropyl-tert.-butylether sowie sec.-Butyl-tert.-butylether. Mixtures of isopropyl tert-butyl ether and sec .-- butyl tert-butyl ether containing from a propane and butane mixture of hydrocarbons produced by separation of a propane and a butane fraction, the isomerization of a portion of the n-butane, catalytically dehydrogenating butane and propane, reacting the propene and n-butenes and butadiene by hydrogenation of the recovered from butene-2 ​​with water into isopropyl alcohol and sec-butyl alcohol, and reacting it with isobutene to form isopropyl tert-butyl ether and sec-butyl tert-butyl butyl ether. Soll das Gemisch auch Isopropylalkohol und/oder sec.-Butylalkohol enthalten, wird jeweils nur ein Teil des betreffenden Alkohols mit Isobuten verathert. If the mixture also contain isopropyl alcohol and / or sec-butyl alcohol, only a part of the relevant alcohol is etherified with isobutene in each case. Ausserdem kann Isobuten zu tert.-Butylalkohol hydratisiert werden. In addition, isobutene can be hydrated to tertiary butyl alcohol. Im Kohlenwasserstoffgemisch enthaltenes Methan und Athan kann in Methylalkohol uberfuhrt und dieser mit Isobuten zu Methyl--tert.-butylether umgesetzt werden. In the hydrocarbon mixture contained methane and ethane can be converted to methyl alcohol, and this with isobutene to form methyl - are reacted tert-butyl ether.

Patent
06 Nov 1982
TL;DR: In this paper, a carboxyalkylcellulose derivative is depolymerized in the presence of H2O2 in an aqueous alkanol solution and, after adjusting the pH, removing the alkanol.
Abstract: PURPOSE:To obtain a particulate or needle-like cellulose derivative with high whiteness and low viscosity, by depolymerizing a high-viscosity carboxyalkylcellulose derivative in the presence of H2O2 in an aqueous alkanol solution and, after adjusting the pH, removing the alkanol. CONSTITUTION:To a system prepared by mixing (i) a 1-4C lower alkanol (e.g., isopropyl alcohol) with (ii) water are added (iii) 100pts.wt. high-viscosity carboxyalkylcellulse derivative in which at least part of the three OH groups in an anhydroglucose unit of cellulose are replaced with groups of the formula, wherein n=1-5, and ether groups and (iv) 0.1-50pts.wt. H2O2, and the mixture is reacted at a temperature of 60 deg.C to the b.p. of the system. Then, the pH of the reaction system is adjusted to 2.5-4 by addition of CH3CO2Na, CF3CO2H or the like. Component (i) is removed by distillation or the like to precipitate a low-viscosity particulate or needle-like cellulose derivative, which is then recovered. USE:Enteric coating agents.

Patent
16 Jul 1982
TL;DR: In this article, a rotary coating machine is used to obtain a reflection preventive film by coating a composition obtained by mixing titanic acid ester, carboxylic acid and p-n junction forming dopant in the prescribed solvent on a semiconductor substrate and then heat treating it.
Abstract: PURPOSE:To simply obtain a reflection preventive film by coating a composition obtained by mixing titanic acid ester, carboxylic acid and p-n junction forming dopant in the prescribed solvent on a semiconductor substrate and then heat treating it. CONSTITUTION:Phosphorus pentaoxide, isopropyl titanate, and acetic acid are added as a dopant to an ethyl alcohol, or isopropyl alcohol as a solvent, and the mixture is agitated. This solution is coated by a rotary coating machine on a P type single crystal silicon wafer 1, and is heat treated in the atmosphere. In the process, an oxidized titanium film 3b containing phosphorus as an impurity is formed on the substrate 1. Thereafter, it is diffused in the nitrogen atmosphere.

Patent
18 Aug 1982
TL;DR: In this article, a method was proposed to quantify vincamine acid of an extremely small amount in ingredients of a living body by extracting a sample, purifying and differentiating the same later, and measuring the fluorescence thereof.
Abstract: PURPOSE:To quantify vincamine acid of an extremely small amount in ingredients of a living body by extracting a sample, purifying and differentiating the same later, and measuring the fluorescence thereof. CONSTITUTION:Urine is diluted with distilled water, 0.01M disodium phosphate of 1.5ml per 1ml of the diluted urine is added thereto, saturation thereof with common salt is conducted, and later pH thereof is adjusted to be 1.5 with hydrochloric acid. Then, a mixture liquid of isopropyl alcohol and chloroform (1:19) is added and, after extraction, an organic layer is dried with anhydrous sodium sulfate. The layer is put in a column for which silica gel is used, cleansed by a mixture liquid of ethyl alcohol and chloroform (1:1) and elutriated later with a mixture liquid of 5ml of ethyl alcohol containing 0.08N triethanolamine and of chloroform (4:1). This elution liquid is destilled, a liquid of 4ml wherein ethyl alcohol and water are mixed equally is added to the residue, the fluorescent intensity thereof is measured, hydrochloric acid is then added thereto, the same measurement is conducted, and the difference between the former and the latter is taken, whereby the value of fluorescence is corrected. When measurement is conducted by this method after the vincamine of 10mg is given orally to a person to be inspected, the result as shown in the figure is obtained. From the figure it is clear that other effects are separated therefrom.

Patent
08 Oct 1982
TL;DR: In this article, a viscosity ratio of 0.9-1.2 is obtained by using isopropyl monochloroacetate as an etherifying agent.
Abstract: PURPOSE:To obtain carboxymethylcellulose having excellent salt water resistance, by producing the carboxymethylcellulose by using isopropyl monochloroacetate as an etherifying agent. CONSTITUTION:Carboxymethylcellulose having a viscosity ratio[the ratio of a viscosity (cP) of a solution of 1wt% carboxymethylcellulose in a 4% aqueous salt solution to that (cP) of a solution of 1wt% carboxymethylcellulose in pure water]of 0.9-1.2 is obtained by using, as an etherifying agent, a product obtained by esterifying at least 50% monochloroacetic acid with isopropyl alcohol in the production of carboxymethylcellulose by using isopropyl alcohol as a reaction solvent. The carboxymethylcellulose thus produced has excellent transparency because the reaction is uniformly carried out and the amount of undissolved swollen gel is small. In addition, the cellulose has remarkably excellent salt water resistance.

Patent
27 Apr 1982
TL;DR: Isopropyl tert-butyl ether and tertbutyl alcohol containing from a propane and butane mixture prepared by separation of a butane fraction, isomerization of n-butane, catalytic dehydrogenation of isobutane and propane as discussed by the authors.
Abstract: Isopropyl tert-butyl ether and tert-butyl alcohol containing from a propane and butane mixture prepared by separation of a propane and a butane fraction, isomerization of n-butane, catalytic dehydrogenation of isobutane and propane, reacting the propene with water to form an isopropyl alcohol -water mixture and reacting it with isobutene to form isopropyl tert-butyl ether and tertiary butyl alcohol. If the product contain isopropyl alcohol, only a portion of the alcohol is etherified with isobutene.

Journal ArticleDOI
TL;DR: In this article, the functionalities of isoprene in a solution of methyl, ethyl, propyl and carbon-labeled isopropyl alcohols were investigated.
Abstract: Oligomerization of isoprene on initiation by hydrogen peroxide in solutions of methyl, ethyl, propyl and carbon-labelled isopropyl alcohols is studied. The radioactive label method reveals that the functionality of the oligomers for fragments of isopropyl alcohol is about 0·5 irrespective of the molecular weight of the oligomers and degree of monomer conversion. The presence of fragments of isopropyl alcohol with the terminal tertiary OH groups in the oligomer molecule is the cause of the reduced (below 2) “effective” functionality of the oligoisoprenes obtained in solution in isopropyl alcohol. In solutions in primary alcohols oligomers containing up to 90% of molecules bifunctional in hydroxyl groups are obtained.

Patent
12 Feb 1982
TL;DR: In this paper, an aqueous solution of a salt (e.g., Na or K) of ceftizoxime shown by the formula and isopropyl alcohol are sterilely filtered and mixed and separating out crystal of dihydrate of the salt by filtration.
Abstract: PURPOSE:To obtain crystal of a salt of ceftizoxime useful as an injection for preparation in use, having high stability and improved quickly dissolving properties, by mixing an aqueous solution of the salt of ceftizoxime with isopropyl alcohol, filtering separating out crystal and drying it. CONSTITUTION:An aqueous solution of a salt (e.g., Na or K) of ceftizomixe shown by the formula and isopropyl alcohol are sterilely filtered and mixed and separating out crystal of dihydrate of ceftizomixe is collected by filtration. The crystal is suspended in isopropyl alcohol to give a suspension, which is dividedly added to vials and dried under vacuum, to give anhydrous crystal. The concentration of the aqueous solution of the salt of ceftizomixe is about 30-50W/V%, and the blending ratio of the aqueous solution and the alcohol is about 1:3. Crystal of the salt of ceftizoxime containing neither admixture nor amorphous crystal is obtained, and reduction in titer of the anhydrous crystal is not observed even by allowing it to stand at 50 deg.C for three months.

Patent
03 Dec 1982
TL;DR: In this paper, an N-Methylolacrylamide is mixed with 2- hydroxyethyl (meth) acrylate monoester and isopropyl alcohol at a molar ratio between 0.001:0.05 and 3:10, and the resultant mixture is neutralized with a compound formula II (R1 is methyl or ethyl ) and then concentrated under ordinary pressure to afford the aimed compound.
Abstract: PURPOSE:To obtain the titled compound useful for preparing water-soluble copolymers easily with the good general-purpose properties, by reacting an N- methylolacrylamide with a phosphoric monoester and isopropyl alcohol under specific conditions, and neutralizing and concentrating the resultant compound. CONSTITUTION:N-Methylolacrylamide[referred to as (A)]is mixed with 2- hydroxyethyl (meth) acrylate monoester[referred to as (B)]expressed by formulaI(R is H or methyl) of phosphoric acid and isopropyl alcohol[referred to as (C)]at a molar ratio between (B) and (A) of 0,001:0.05 and a molar ratio between (C) and (A) of 3:10, and if necessary and acid, e.g. acrylic acid or methacrylic acid, other than the component (B) is added thereto. The resultant mixture is then heated in the presence of a polymerization inhibitor and condensed through dehyration without requiring a decanter of a reaction apparatus. The resultant compound is neutralized with a compound formula II (R1 is methyl or ethyl ) and then concentrated under ordinary pressure to afford the aimed compound.

Patent
15 Jun 1982
TL;DR: In this article, an alkyl halide is reacted with sulfur in the presence of a metal of Mo, W, Sb or Cu as a catalyst and sodium sulfite in an alkaline alcoholic aqueous solution.
Abstract: PURPOSE:To obtain the titled compound which is an intermediate for agricultural chemicals, etc in high yield, by reacting an alkyl halide with sulfur in the presence of a substance containing a metal of Mo, W, Sb or Cu as a catalyst and sodium sulfite in an alkaline alcoholic aqueous solution CONSTITUTION:An alkyl halide, eg methyl chloride, is reacted with sulfur in the presence of a substance containing a metal of Mo, W, Sb or Cu, eg molybdic acid or antimony trioxide, as a catalyst and sodium sulfite in an alkaline alcoholic aqueous solution, eg a mixed solution of an aqueous solution of sodium hydroxide with ethyl alcohol or isopropyl alcohol, to give a dialkyl disulfide The concentration of the alkali in the alcoholic aqueous solution is 5-80%, preferably 15-50%, based on the alcohol, and the reaction temperature is preferably 100-150 degC