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Showing papers on "Isopropyl alcohol published in 1987"



Patent
08 Sep 1987
TL;DR: A medicated skin composition comprises a mixture of a copolymer of methylvinylether and methacrylic acid, isopropyl alcohol, citric acid ester plasticizer and 2,4,4'-trichloro-2'-hydroxydiphenyl ether.
Abstract: A medicated skin composition comprises a mixture of a copolymer of methylvinylether and methacrylic acid, isopropyl alcohol, citric acid ester plasticizer and 2,4,4'-trichloro-2'-hydroxydiphenyl ether. This composition is applied to the skin to form an antimicrobial barrier.

29 citations


Patent
08 Dec 1987
TL;DR: In this article, a water-tree, film-forming antifungal composition was obtained by using tolnaftate, dimethylaminoethyl methacrylate-methacryl ester copolymer and a medium-size chain fatty acid ester in an alcohol solvent.
Abstract: PURPOSE: To obtain a water-tree, film-forming antifungal composition, by using tolnaftate, dimethylaminoethyl methacrylate-methacrylate ester copolymer and a medium-size chain fatty acid ester in an alcohol solvent. CONSTITUTION: 0.1W1.5% of tolnaftate, 10W20% of dimethylaminoethyl methacrylate-methacrylate copolymer and 0.5W10% of a medium-sized chain fatty acid ester such as tetraglyceryl monocaprilate are dissolved in an alcoholic solvent such as ethanol or isopropyl alcohol. When needed, 0.1W5% of a thickener such as ethyl cellulose is added thereto to give the subject composition. Tolnaftate has a powerful antirungal action, especially against trichophyton, and the composition forms a flexible and strong film on the skin to maintain the effect of the drug for hours after application. COPYRIGHT: (C)1989,JPO&Japio

20 citations


Journal ArticleDOI
TL;DR: A number of N-protected derivatives of 2,4,5-tribromoimidazole, 4(5)-bromo-5(4)-nitroimidrazole, and 2, 4,5)-dibromo-(5,1-b]thiazine-2-carboxylate) have been prepared by standard procedures and treated with various nucleophiles as discussed by the authors.
Abstract: A number of N-protected derivatives of 2,4,5-tribromoimidazole, 4(5)-bromo-5(4)-nitroimidazole, and 2,4(5)-dibromo-5(4)-nitroimidazole have been prepared by standard procedures and treated with various nucleophiles. Whereas 2,4,5-tribromo (and tri-iodo)imidazole reacted with sodium benzenethiolate to give the corresponding 4,5-dihalogenoimidazole and diphenyl disulphide, 1-protected derivatives of 2,4,5-tribromoimidazole reacted with various sodium alkane (or arene)thiolates and with sodium isopropoxide, in isopropyl alcohol, by displacement of the 2-bromine atom. 1-Benzyl-5-bromo-4-nitroimidazole (14), 2-(5-bromo-4-nitroimidazol-1-yl)acetate (25), and 5-bromo-4-nitro-1-phenacylimidazole (26) reacted by displacement of the 5-bromine atom. The product arising from reaction of the last compound with ethyl 2-mercaptoacetate in ethanol in the presence of base, cyclised to give ethyl 3-hydroxy-7-nitro-3-phenylimidazolo[5,1-b]thiazine-2-carboxylate (35).

13 citations


Patent
19 Nov 1987
TL;DR: In 1989, JPO&Japio as discussed by the authors provided the title detergent having excellent cleaning effect, capable of soft finishing, inert to plastics and metals, causing no problems such as the ozone depletion in the stratosphere and groundwater contamination, containing as the active ingredient, a dichloro fluorethane.
Abstract: PURPOSE: To provide the title detergent having excellent cleaning effect, capable of soft finishing, inert to plastics and metals, etc., causing no problems such as the ozone depletion in the stratosphere and groundwater contamination, containing as the active ingredient, a dichloro fluorethane. CONSTITUTION: The objective detergent containing, as the active ingredient, 1,1-dichloro-2-fluorethane or 1,1-dichloro-1-fluorethane, and furthermore, if needed containing pref. 20W30wt.% of hydrocarbon(s) (pref. n-pentane, n-hexane or n-heptane), alcohol(s) (pref. methanol, ethanol or isopropyl alcohol), hetone(s) (pref. acetone or methyl ethyl hetone), chlorinated hydrocarbon(s) (pref. methylene chloride, 1,1,1-trichloroethane or trichloroethylene), and/or surfactant (pref. polyethylene lauryl ether). COPYRIGHT: (C)1989,JPO&Japio

12 citations


Patent
06 Apr 1987
TL;DR: In this paper, acid-fast bacilli are stained with a primary stain and then with a decolorizing counter-stain that does not require a separate acid or alcohol decolorization step.
Abstract: Acid-fast bacilli are stained with a primary stain that does not require heating and then with a decolorizing counter-stain that does not require a separate acid or alcohol decolorization step. The primary stain includes basic fuchsin, ethyl alcohol, isopropyl alcohol, phenol and water. The counter-stain includes methylene blue, ethyl alcohol, potassium hydroxide, glycerol, glacial acetic acid, polyvinylpyrrolidone and water.

5 citations


Patent
16 Jun 1987
TL;DR: In this paper, the authors proposed a method to produce a highly hydrogenated polymer in high yield, by hydrogenating a hydroxyl group-containing diene polymer, treating a solution of the reaction product with an alcohol and hydrogenating the prepared dark solution.
Abstract: PURPOSE:To produce a highly hydrogenated polymer in high yield, by hydrogenating a hydroxyl group-containing diene polymer, treating a solution of the reaction product with an alcohol and hydrogenating the prepared dark solution CONSTITUTION:A diene polymer [eg, butadiene polymer, chloroprene polymer, etc, shown by the formula (R is H, Cl or CH3; n is 5-300), etc,] containing hydroxyl groups preferably at both molecular ends is catalytically hydrolyzed in a solvent such as pentane, cyclohexane, etc, usually by the use of a catalyst of Ni, Pd, etc, supported on a carrier such as silica, alumina, etc, preferably at 100-200 degC at 30-100kg/cm G for 5-10hr and a solution of the hydrogenation product is treated with an alcohol such as isopropyl alcohol to give two layers A dark solution containing a low hydrogenated polymer, an unhydrogenated polymer and the catalyst, a lower layer of the separated two layers, is hydrogenated again and added to a bright solution, a highly hydrogenated polymer solution at the upper layer

4 citations


Patent
10 Apr 1987
TL;DR: In this article, the authors showed that the yield of cyclodextrins formed in the hydrolysis of starch catalyzed by a CGM can be substantially increased by the addition of certain water-soluble solutes, such as ethanol and isopropyl alcohol.
Abstract: The yield of cyclodextrins formed in the hydrolysis of starch catalyzed by a cyclodextrin glycosyltransferase can be substantially increased by the addition of certain water-soluble solutes. Alcohols containing 1 to 6 carbon atoms form one such class, with ethanol and isopropyl alcohol being especially effective. Where an immobilized cyclodextrin glycosyltransferase is used yields of beta-cyclodextrin can be increased from approximately 20% to almost 40% using 15% isopropyl alcohol in a thinned starch feedstock, with glucose production being increased by only about 25%.

4 citations


Journal ArticleDOI
TL;DR: In this paper, α, ω-type amphoteric surfactants containing bisbetaine groups were synthesized by reactions of alkanedioic acids with N, N-dimethyl-1, 3-propanediamine, and quaternization of the resulting bisaminoamides with sodium chloroacetate.
Abstract: α, ω-Type amphoteric surfactants containing bisbetaine groups were synthesized by reactions of alkanedioic acids with N, N-dimethyl-1, 3-propanediamine, followed by quaternization of the resulting bisaminoamides with sodium chloroacetate. The latter process was carried out in water or a mixture of isopropyl alcohol and water using sodium hydrogencarbonate or sodium hydroxide as the catalyst.The properties of the α, ω-bisamidobetaine in aqueous solution were studied. α, ω-Bisamidobetaines derived from hexadecanedioic and icosanedioic acid showed good catalytic activity for the halide displacement reaction and a excellent ability to bring about lime soap dispersion.

4 citations


Patent
06 Jul 1987
TL;DR: In this paper, a diene polymer containing hydroxyl groups is catalytically hydrogenated in a solvent such as pentane, cyclohexane, etc., usually by the use of a catalyst of Ni, Pd, supported on a carrier such as silica, alumina, etc.
Abstract: PURPOSE:To separate a highly hydrogenated polymer readily and to produce the aimed substance in high yield, by hydrogenating a hydroxyl group-containing diene polymer and treating a solution of the prepared reaction product with an alcohol. CONSTITUTION:A diene polymer [e.g., butadiene polymer, chloroprene polymer, etc., shown by the formula (R is H, Cl or CH3; n is 5-300)] containing hydroxyl groups preferably at both molecular ends is catalytically hydrogenated in a solvent such as pentane, cyclohexane, etc., usually by the use of a catalyst of Ni, Pd, etc., supported on a carrier such as silica, alumina, etc., preferably at 100-200 deg.C at 30-100kg/cm G for 5-10hr and a solution of the prepared hydrogenation product is treated with an alcohol such as isopropyl alcohol, etc. EFFECT:When a solution of prepared hydrogenation product is blended with an alcohol, the solution divided into two layers of the bright solution of the aimed highly hydrogenated polymer and a dark solution containing a nuhydrogenated polymer, a low hydrogenated polymer and a catalyst and separation is readily carried out.

4 citations


Patent
03 Jul 1987
TL;DR: In this article, water-containing isopropyl alcohol is mixed with cellulose and 2.0-6.0mol, per anhydroglucose unit of the cellulose, of an alkali (e.g., NaOH), and the mixture is reacted at 10-30 deg.C for 60-120min to obtain alkali cellulose.
Abstract: PURPOSE:To produce an alkali metal salt of carboxymethylcellulose ether of a low degree substitution and excellent salt water resistance, by adding an etherifying agent to a specified alkali cellulose and etherifying it. CONSTITUTION:Water-containing isopropyl alcohol is mixed with cellulose and 2.0-6.0mol, per anhydroglucose unit of the cellulose, of an alkali (e.g., NaOH), and the mixture is reacted at 10-30 deg.C for 60-120min to obtain alkali cellulose. An organic acid isopropyl ester (e.g., isopropyl formate) and isopropyl monochloroacetate are added in small portions to the alkali cellulose at 10-40 deg.C so that the amount of the alkali in the reaction system may be 0.95-1.20mol%, based on anhydroglucose unit of the cellulose. The mixture is agitated at 10-30 deg.C for 30min and is ehterified at 60-80 deg.C for 60-360min to obtain an alkali metal salt of carboxymethylcellulose ether of a low degree substitution (i.e. 0.45-0.75).

Patent
18 Dec 1987
TL;DR: In this paper, a process for the purification of the crude isopropyl alcohol product of propylene hydration reactions was proposed, which is particularly useful in removing odiferous sulfur-containing impurities.
Abstract: A process for the purification of the crude isopropyl alcohol product of propylene hydration reactions. Crude isopropyl alcohol products, which comprise isopropyl alcohol, diisopropyl ether and polymeric impurities, are subjected to a specified sequence of multiple dilution and phase separation steps which serve to extract a substantial portion of the product's diisopropyl ether and polymeric impurities. The invention is particularly useful in removing odiferous sulfur-containing impurities from the products of indirect propylene hydration processes which involve the reaction of propylene with sulfuric acid to produce isopropyl sulfate followed by hydrolysis of the sulfate to isopropyl alcohol.

Patent
28 Oct 1987
TL;DR: In this article, a cellulosic material (e.g., wood pulp) with an alkali (i.e., NaOH) is reacted with a water-containing organic solvent of a specified concentration and allowed an etherifying agent to act upon the reaction product.
Abstract: PURPOSE:To obtain the titled compound excellent in salt water resistance, by reacting a cellulosic material with an alkali in a water-containing organic solvent of a specified concentration and allowing an etherifying agent to act upon the reaction product. CONSTITUTION:An alkali cellulose obtained by reacting an alkali cellulose obtained by reacting a cellulosic material (A) (e.g., wood pulp) with an alkali (B) (e.g., NaOH) at 5-40 deg.C for 10-180min at 5-40 deg.C in 1-30pts.wt., per pt.wt. component A, water-containing organic solvent of a solvent concentration >=90wt%, preferably, >=92wt% (e.g., a mixed solvent comprising water and at least 90% isopropyl alcohol) and an etherifying agent (C) (e.g., monochloroacetic acid) are mixed together at 5-40 deg.C for 10-60min so that the solvent concentration may be 90% or below, and the obtained mixture is subjected to an etherification reaction at 60-80 deg.C for 60-360min.

Patent
10 Jan 1987
TL;DR: In this paper, a brassinosteroid (including optical isomers) shown by the formula well-known as a synthetic plant hormone is dissolved in an organic solvent selected from benzene, n-pentane, hexane, toluene, xylene, CCl4, chloroform, monochlorobenzene, ethyl ether, acetone, methyl ethyl ketone and methyl acetate, butyl acetate.
Abstract: PURPOSE:To carry out growth promotion treatment of cultivated plant with a small amount of agent by a simple operation and to enable increase in yield, by immersing seeds of the cultivated plant in a solution of a brassinosteroid in a specific organic solve, of small art in a short time. CONSTITUTION:A brassinosteroid (including optical isomers) shown by the formula well-known as a synthetic plant hormone is dissolved in an organic solvent selected from benzene, n-pentane, hexane, toluene, xylene, CCl4, chloroform, monochlorobenzene, ethyl ether, acetone, methyl ethyl ketone, methyl acetate, ethyl acetate, butyl acetate, ethanol, isopropyl alcohol, n-butyl alcohol, glycerin, acetonitrile and CS2 to give a solution, in which seeds of cultivated plant such as tomato, Japanese radish, rice plant, etc., are immersed. EFFECT:The solution can be applied to seeds having insufficient water permeability, treatment has no influence on germination and seeds after immersion treatment can be preserved.

Patent
14 Aug 1987
TL;DR: In this article, ultrasonic vibration was applied in a monochloroacetic acid mixing step or an etherification step instead of the alkali cellulose forming reaction step to obtain the metal salt having very excellent transparency.
Abstract: PURPOSE:To obtain the titled metal salt having very excellent transparency, by applying ultrasonic vibration in any one of an alkali cellulose forming reaction step and other steps in the production of an alkali metal salt of CMC. CONSTITUTION:Crushed raw pulp is dispersed in a mixture of isopropyl alcohol and water. The dispersion is stirred to carry out a pretreatment and the reaction bath is sealed with a nitrogen gas. An aq. NaOH soln. is added thereto. While ultrasonic vibration is applied to the reaction soln. with ultrasonic waves generated by an ultrasonic cleaner, etc., the soln. is stirred to carry out an alkali cellulose forming reaction. A soln. of monochloroacetic acid in isopropyl alcohol is added thereto. For example, monochloroacetic acid is thoroughly mixed at 15-20 deg.C, and the temp. is elevated to about 70 deg.C to carry out an etherification reaction. The reaction mixture is cooled to about 40 deg.C, neutralized and filtered. If desired, washing and filtration are repeated. The reaction product is dried at about 90 deg.C to obtain the desired product. Said ultrasonic vibration may be applied in a monochloroacetic acid mixing step or an etherification step, instead of the alkali cellulose forming reaction step.

Patent
11 Feb 1987
TL;DR: Isopropyl alcohol and titanium tetrachloride are first put to esterification, obtaining isoperpyl titanate, which can be applied in paints as dispersing, thixotropic and ultraviolet absorbing agents as mentioned in this paper.
Abstract: This is a completely closed circulating process which contains esterification and chelating reactions. Isopropyl alcohol and titanium tetrachloride are first put to esterification (isopropyl alcohol itself as solvent) obtaining isoperpyl titanate. The titanate (as intermediate) is then chelated with ethanolamine forming isopropyl ethanolamine titanate. This compound has good dispersivity, thixotropy, and ultraviolet absorbility. It can be applied in paints as dispersing, thixotropic and ultraviolet absorbing agents.

Journal ArticleDOI
TL;DR: In this paper, 1, 2-bis benzene with potassium hydroxide in methanol, ethanol, or isopropyl alcohol was shown to yield 3, 6-dihydro-5-isocyano-3-benzazocin-2 (1H) -one.
Abstract: Treatment of 1, 2-bis (2-isocyano-2-tosylethyl) benzene (5a) with potassium hydroxide in methanol, ethanol, or isopropyl alcohol afforded 2-substituted 1, 6-dihydro-5-isocyano-3-benzazocines (15a-c) by intramolecular cyclization. When tert-butyl alcohol was used as a solvent under the same conditions, 5a was led to 3, 6-dihydro-5-isocyano-3-benzazocin-2 (1H) -one (18) instead of the corresponding benzazocine of type 15d. N-Alkylation of 18 with methyl, ethyl, and isopropyl iodides yielded 3-alkylated 3, 6-dihydro-5-isocyano-3-benzazocin-2 (1H) -ones (20a-c), which are structural isomers of 15a-c.

Patent
25 Aug 1987
TL;DR: In this paper, a method for producing crystalline cefadroxil hemihydrate is described, in which a solvate is slurried with a mixture methanol:isopropyl alcohol 30:70 to 70:30 by volume containing from 5% to 12% of water, a temperature from +45° C. to +55° C, and then isolating the so obtained crystalline compound.
Abstract: The invention relates to a method for producing crystalline cefadroxil hemihydrate. According to the method a cefadroxil solvate is slurried with a mixture methanol:isopropyl alcohol 30:70 to 70:30 by volume containing from 5% to 12% of water, a temperature from +45° C. to +55° C. and then isolating the so obtained crystalline compound.

Journal ArticleDOI
TL;DR: In this paper, the activation energy of the reaction is calculated and the effect of varying the initial temperature as well as different additives on the thermometric behavior of isopropyl alcohol is studied.

Patent
24 Dec 1987
TL;DR: In this paper, a polysiloxane solution is combined with an alcohol such as isopropyl alcohol to prevent oil film formation and easily remove oil, and an organic fluorine compound and a solvent such as xylene are added to give the subject water and oil-repellent agent.
Abstract: PURPOSE: To obtain a water-repellent and oil-repellent agent which can prevents oil film formation and easily remove oil, by adding an alcohol to a solution of a polysiloxane chain-broken with a strong acid to effect dehydration, as well as an organic fluorine compound. CONSTITUTION: The bonds between Si and 0 in polysiloxane is broken with a strong acid such as nitric acid or sulfuric acid. The polysiloxane solution is combined with an alcohol such as isopropyl alcohol to effect dehydration. Then, an organic fluorine compound and a solvent such as xylene, when needed, are added to give the subject water and oil-repellent agent. It is preferred to use dichloroethane as a drying accelerator. COPYRIGHT: (C)1989,JPO&Japio

Patent
16 Oct 1987
TL;DR: In this article, a lower alcohol such as isopropyl alcohol is added to the prescribed emulsion, preferably as a state of mist in the desalting process of the emulsion.
Abstract: PURPOSE:To improve a defoaming effect in a producing step of the titled emulsion by incorporating a lower alcohol to the prescribed emulsion in a desalting process of the emulsion. CONSTITUTION:The lower alcohol 2 such as isopropyl alcohol is added to the prescribed emulsion, preferably as a state of mist in the desalting process of the emulsion. For example, the alcohol 2 stored in a charging vessel 1 is supplied to a holding tank 6, by opening valve 3, 5, while measuring the alcohol by a measuring device 4. And then valves 8, 10 are opened the alcohol 2 is spraied into the emulsion from a nozzle 12 utilizing an air pressure. By the titled process, the defoaming is effectively carried out. When adding the alcohol to the emulsion in the mist state, the defoaming is more effectively carried out utilizing a small amount of the alcohol 2.



Patent
21 Jul 1987
TL;DR: In this paper, the titled fuel compsn. which is suitable for use in hiking or mounting is presented, which comprises isopropyl alcohol, methyl alcohol, water, polyethylene glycol and a sodium salt.
Abstract: PURPOSE:To provide the titled fuel compsn. which evaporates and burns with odorless, colored flame having high heating power through a flame reaction enabling the state of ignition to be clearly observed under a cloudless sky in an open air and is suitable for use in hiking or mounting, which comprises isopropyl alcohol, methyl alcohol, water, polyethylene glycol and a sodium salt. CONSTITUTION:50wt% or more isopropyl alcohol (A) is blended with 10-45wt% methyl alcohol (B), 3-20wt% water (C) which is an essential component for assisting the solubility of the components (D) and (E), 0.5-2wt% water-soluble polymer (D) comprised of polyethylene having an MW of 500,000-10,000,000, and 0.05-0.5wt% flame reaction agent (E) comprised of a sodium salt (e.g., NaCl).

Journal ArticleDOI
TL;DR: The gas-phase equilibria for hydration reactions of protonated methyl alcohol, ethyl alcohol, n-propyl alcohol and isopropyl alcohol were measured with a pulsed electron beam mass spectrometer as mentioned in this paper.
Abstract: The gas-phase equilibria for hydration reactions of protonated methyl alcohol, ethyl alcohol, n-propyl alcohol, and isopropyl alcohol, ROH/sub 2//sup +/(H/sub 2/O)/sub n-1/ + H/sub 2/O = ROH/sub 2//sup +/(H/sub 2/O)/sub n/, were measured with a pulsed electron beam mass spectrometer. Van't Hoff plots of the equilibrium constants lead to ..delta..H/sup 0//sub n-1/,n/ and ..delta..S/sup 0//sub n-1,n/ up to n = 6. While the proton affinities increase in the order methyl alcohol < ethyl alcohol < n-propyl alcohol < isopropyl alcohol, the stabilities of clusters ROH/sub 2//sup +/(H/sub 2/O)/sub n/ toward dissociation increase in the reverse order, i.e., isopropyl alcohol < n-propyl alcohol < ethyl alcohol < methyl alcohol. The deprotonation from the base alcohol in the cluster ROH/sub 2//sup +/ (H/sub 2/O)/sub n/ was not observed up to n = 6 or 7. The acid-catalyzed dehydration of alcohols was not observed either. The stepwise sums of free energy changes ..delta..G/sup 0//sub n-1,n/ for gas-phase hydration reactions of protonated alcohols and other ions are compared with the free energies of hydration. The anomalous order of basicities for H/sub 2/O and aliphatic alcohols is suggested in the gas phase and in aqueous solution. The sums of ..delta..G/sup 0//sub n-1,n/ for halide ionsmore » converge more gradually to the ultimate free energies of hydration than those for other positive ions.« less

Journal ArticleDOI
TL;DR: In this article, the ion/molecule reactions observed in 4 Torr CH4 containing known small amounts of i-C3H7OH or C3H13O+ were studied over the temperature range 40-400 °C using a pulsed electron beam mass spectrometer.
Abstract: The ion/molecule reactions observed in 4 Torr CH4 containing known small amounts of i-C3H7OH or i-C3H7OH/H2O mixture were studied over the temperature range 40–400 °C The experiments were carried out using a pulsed electron beam mass spectrometer At low temperatures (<150 °C), the major ions are i-C3H7OH2+(i-C3H7OH)n By increasing the temperature, the slow growth of ions with m⁄z=59, 85, and 101 is observed These ions are assigned to (CH3)2COH+, (CH3)2CHC+(CH3)2, and C6H13O+, respectively They are probably produced from reactions of i-C3H7+ with isopropyl alcohol The (CH3)2COH+ ion may be produced from the electrophilic attack of i-C3H7+ onto the secondary carbon atom of i-C3H7OH At high temperatures (≈400 °C), the (CH3)2COH+ ion becomes dominant Acid-catalyzed dehydration of isopropyl alcohol, i-C3H7OH2++H2O→H3O+(H2O)+C3H6, is also observed Ion/molecule reactions involved in the present experiment are discussed according to the frontier-orbital theory

Patent
05 Jan 1987
TL;DR: In this article, a process for deodorizing technical-grade isopropyl alcohol by contacting the alcohol with a strongly acidic cation exchange resin loaded with palladium in ionic form is provided.
Abstract: A process for deodorizing technical-grade isopropyl alcohol by contacting the alcohol with a strongly acidic cation exchange resin loaded with palladium in ionic form is provided.

Patent
19 Nov 1987
TL;DR: In this article, a compound shown by formula I. was oxidized to convert CH2OH into COOH and reacted with benzene in the presence of lead tetracetate.
Abstract: NEW MATERIAL:A compound shown by formula I. USE:Perfume having grapefruit-like citrous aroma. PREPARATION:2-Ethylidenebicyclo[2.2.1]heptane-5(or 6)carboaldehyde shown by formula II and formaldehyde are subjected to cannizzaro reaction to give a compound shown by formula III, which is heated in an acidic condition (sulfu ric acid, phosphoric acid, etc.) in a solvent such as isopropyl alcohol, etc., under reflux to give a compound shown by formula IV. This compound is oxidized to convert CH2OH into COOH and reacted with benzene in the presence of lead tetracetate to give a compound shown by formula I.

Journal ArticleDOI
TL;DR: In this article, the reductive aminolysis of p-fluoroacetaminocinnamic acid azalactone by S-(-)-a-phenylethylamine in the presence of PdCl2 and H2 in dimethoxyethane or isopropyl alcohol was formed with 28 and 46% excesses of the SS diastereomer, respectively.
Abstract: 1. In reductive aminolysis of p-fluoroacetaminocinnamic acid azalactone by S-(-)-a-phenylethylamine in the presence of PdCl2 and H2 in dimethoxyethane or isopropyl alcohol, N-acetyl-p-fluorophenylalanine phenylethylamide was formed with 28 and 46% excesses of the SS diastereomer, respectively, the hydrolysis of which, after crystallization, afforded optically pure S-(-)-p-fluorophenylalanine. 2. Hydrogenation of p-fluoroacetaminocinnamic acid S-(+)-phenylethylamide in isopropyl alcohol and dimethoxyethane occurred stereoselectively and afforded N-acetyl-p-fluorophenyl-alanine phenylethylamide with 10% excess of the RS diastereomer.

Patent
20 Mar 1987
TL;DR: In this paper, the double carbonylation of organic halides for the purpose of forming 2-oxocarboxylic acid esters is described, and the reaction takes place at a temperature from 25 to 200 DEG C and under a total pressure of 0.1 to 20 MPa.
Abstract: Process for the double carbonylation of organic halides for the purpose of forming 2-oxocarboxylic acid esters. The process consists in reacting, in liquid phase, a hydrocarbon halide with a gas containing carbon monoxide and with an alcohol in the presence of a palladium-based catalyst and in the presence of at least one compound B chosen from the group formed by the carboxylates and carbonates of alkali metals and alkaline-earth metals. The catalyst preferably contains an organic ligand containing at least one phosphorus, arsenic or antimony atom. The process makes it possible to prepare the isopropyl ester of phenylglyoxylic acid from iodobenzene and isopropyl alcohol. The reaction takes place at a temperature from 25 to 200 DEG C and under a total pressure of 0.1 to 20 MPa.