Isopropyl alcohol

About: Isopropyl alcohol is a research topic. Over the lifetime, 3064 publications have been published within this topic receiving 27354 citations. The topic is also known as: Rubbing Alcohol & Propan-2-ol.

Liquid agent for external use

Abstract: PURPOSE: A liquid agent for external use in the form a stable solution, having excellent absorption, and consisting of Indomethacin and specified solvents. CONSTITUTION: A liquid agent for external use consisting of Indomethacin and a lower alcohol, e.g. isopropyl alcohol, and/or acetone, a glycol, e.g. polyethylene glycol, and/or an ester thereof, e.g. polyethylene glycol monolaurate, and water as solvents. Althrough only a little soluble in water, Indomethacin is dissolved stably in the solvents of the composition, and has an excellent feeling of use and a sufficient drug action as a nonteroidal antiphlogistic and analgesic agent. COPYRIGHT: (C)1981,JPO&Japio

Diffusive sampling and biological monitoring of 2-bromopropane

Abstract: The possibilities to apply personal ambient air monitoring by diffusive sampling and biological exposure monitoring by urinalysis for 2-bromopropane or its metabolites were explored. The abilities of carbon cloth to adsorb 2-bromopropane was examined by experimental vapor exposure followed by solvent extraction and FID-GC. Urine from factory workers and rats exposed to 2-bromopropane were analyzed for 2-bromopropane, acetone and isopropyl alcohol by FID-GC, and for bromide ion by ECD-GC after chemical methylation. Carbon cloth adsorbed 2-bromopropane in a manner linearly related to exposures up to 1500 mg/m3 and to 8 h. The adsorption could quantitatively detect a 15 min peak exposure at 3,000 mg/m3. In rat experiments, analyses of urine samples collected over a 4-h period after termination of a 4-h exposure to 2-bromopropane at 500, 1,000 or 1,500 mg/m3 showed that acetone and bromide ion were excreted dose-dependently. Essentially, no 2-bromopropane or isopropyl alcohol was detected. When the analytical methods were applied to urine samples from 5 male workers exposed to 2-bromopropane at a low level (3 mg/m3 as a geometric mean), acetone and bromide ion levels were within respective normal ranges in four cases, but were higher than the upper limits of the normal ranges in the fifth case of a foreman who probably had the highest exposure. Thus, diffusive sampling is applicable to monitor exposure to 2-bromopropane. Urinalysis for acetone and bromide ion in combination appears to be a promising selective tool for biological monitoring of occupational exposure to 2-bromopropane.

Isopropyl alcohol in cows suffering from acetonaemia.

Abstract: WE wish to record the finding of considerable amounts of isopropyl alcohol in the blood, milk and rumen contents of cows suffering from acetonaemia, whereas there appears to be none present in normal animals. This means that the figures given hitherto for (β-hydroxybutyric acid in the literature on that condition are probably misleading, as by most of the usual methods of analysis isopropyl alcohol would be estimated with that fraction. Moreover, in view of its close relationship to acetone, isopropyl alcohol might be either a precursor or a metabolic product of that substance. If the former is the case, it would necessitate an entirely new approach to the problem of the development of ketone bodies in this disease.

Solubility Modeling and Solvent Effect for Flubendazole in 12 Neat Solvents

Abstract: The method of shake-flask was used in studying the solubility of flubendazole in water, n-propanol, ethanol, isopropyl alcohol, methanol, isobutyl alcohol, n-butanol, N,N-dimethylformamide, 1,4-dioxane, 2-butanone, dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone. The determination was made over the temperatures from 283.15 K to 333.15 K under ambient pressure p = 101.2 kPa. The values of flubendazole solubility in mole fraction in these solvents increased with rising temperature. They were highest in DMSO and lowest in water. The gained solubility was mathematically described through the Apelblat equation. The maximum average relative deviation and root-mean-square deviation were 2.69% and 3.60 × 10–5, respectively. In addition, using the relationship analysis of linear solvation energy of solvent effect, the degree and type of solvent–solvent and solute–solvent interactions were identified.