Topic
Isotopes of chromium
About: Isotopes of chromium is a research topic. Over the lifetime, 51 publications have been published within this topic receiving 877 citations. The topic is also known as: Chromium Isotopes.
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TL;DR: In this paper, the retention of chromium was measured with a whole-body counter for 8 mo and blood levels were measured for 40--80 days, revealing three exponential components with T1/2s of.56 days, 12.7 days, and 192 days.
Abstract: Chromium (III) has recently been shown to be an essential trace mineral in rats, being required for normal function of insulin in controlling glucose metabolism. Chromium is transported in the body bound to transferrin, where it binds competitively with iron. Hemochromatosis is an iron storage disease in humans characterized by highly saturated transferrin levels and sometimes by diabetes. We postulated that the diabetes may be due to exclusion of chromium by iron at metabolic binding sites. 51Cr(III) was administered i.v. to 5 normal males, 6 patients with hemochromatosis prior to therapeutic removal of iron, and 5 patients with varying levels of iron loading. The retention of 51Cr was measured with a whole-body counter for 8 mo and blood levels were measured for 40--80 days. Analysis of the whole-body retention curves revealed 3 exponential components with T1/2s of .56 days, 12.7 days, and 192 days; the blood curves had 4 components with T1/2s of 13 min; 6.3 hr, 1.9 days, and 8.3 days. The T1/2s were not significantly different between the normals and patients. The coefficients of these components however, were significantly lower for the long T1/2 components in the iron-loaded patients, demonstrating reduced retention of 51Cr as postulated. Whether this reduced retention of chromium is causally related to diabetes in hemochromatosis and whether abnormal chromium metabolism is involved in endogenous diabetes, thus, becomes an important question for future study.
43 citations
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TL;DR: Isotope effects for zinc upon complex formation with dicyclohexano-18-crown-6 were investigated in this paper, where the single stage separation factor for unit mass difference (α = 1.013) was great compared with that of calcium isotopes.
Abstract: Isotope effects for zinc upon complex formation with dicyclohexano-18-crown-6 were investigated. The single stage separation factor for unit mass difference (α = 1.013) was great compared with that of calcium isotopes. One of the isotopes, 67Zn, showed a larger isotope effect than the other isotopes of even mass number.
37 citations
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35 citations
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TL;DR: Values of C/sub d-er/ determined repeatedly in two dogs intravenously infused with Cr/sup 51/Cl/sup 3/ for over 7 hr remained stable, indicating that renal function was not impaired by the doses of chromium used and the conclusion that tubular excretion is of minor importance.
Abstract: Renal clearance of chromium decreases exponentially with time after a single intravenous injection of Cr51Cl3 from 2.5 or 3 ml/min/m2 at 1 hr to less than 1 ml/min 8 hr post-injection. Equilibrium ...
32 citations