Topic
Isovitexin
About: Isovitexin is a research topic. Over the lifetime, 526 publications have been published within this topic receiving 11525 citations. The topic is also known as: 6-Glucosylapigenin & Isovitexin.
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TL;DR: A new flavone glycoside has been isolated from Scoparia dulcis together with 11 known compounds and showed inhibitory activity against β-glucuronidase.
57 citations
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TL;DR: The major flavone in mature cocoa leaves is isoviteXin, with smaller amounts of vitexin and 7- O -glucosides of apigenin, luteolin and chrysoeriol.
57 citations
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TL;DR: A two-step method using thin-layer Chromatography (TLC) and high pressure liquid chromatography (HPLC) for the rapid identification and quantification of the flavones C-glycosides in C. nutans leaves is developed.
Abstract: Clinacanthus nutans (family Acanthaceae) has been used for the treatment of inflammation and herpes viral infection. Currently, there has not been any report on the qualitative and quantitative determination of the chemical markers in the leaves of C. nutans. The C-glycosidic flavones such as shaftoside, isoorientin, orientin, isovitexin, and vitexin have been found to be major flavonoids in the leaves of this plant. Therefore, we had developed a two-step method using thin-layer chromatography (TLC) and high pressure liquid chromatography (HPLC) for the rapid identification and quantification of the flavones C-glycosides in C. nutans leaves. The TLC separation of the chemical markers was achieved on silica gel 60 plate using ethyl acetate : formic acid : acetic acid : water (100 : 11 : 11 : 27 v/v/v/v) as the mobile phase. HPLC method was optimized and validated for the quantification of shaftoside, orientin, isovitexin, and vitexin and was shown to be linear in concentration range tested (0.4–200 μg/mL, r2 ≥ 0.996), precise (RSD ≤ 4.54%), and accurate (95–105%). The concentration of shaftoside, orientin, vitexin, and isovitexin in C. nutans leave samples was 2.55–17.43, 0.00–0.86, 0.00–2.01, and 0.00–0.91 mmol/g, respectively.
55 citations
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TL;DR: In this article, the authors measured the antioxidant capacities of the soup prepared with three cultivars of mung bean and found that the two major flavonoids in the MBS were purified and identified as vitexin and isovitexins, respectively.
55 citations
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TL;DR: A new flavone C-glycoside, isovitexin 6"-O-glucoside (1), and three known flavonoids, quercetin,IsoviteXin, and luteolin-7-O-beta-D-glUCoside, have been further isolated from the whole plant of Gentiana arisanensis Hayata by spectral methods and chemical reactions.
Abstract: A new flavone C-glycoside, isovitexin 6‘‘-O-glucoside (1), and three known flavonoids, quercetin, isovitexin, and luteolin-7-O-β-d-glucoside, have been further isolated from the whole plant of Gentiana arisanensis Hayata. The new compound was characterized by spectral methods and chemical reactions. The antiplatelet effects of isovitexin 6‘‘-O-glucoside (1), isoorientin (2), 2 peracetate (3), isovitexin (4), luteolin 7-O-β-d-glucoside (5), luteolin (6), isoorientin 6‘‘-O-glucoside (7), and 7 peracetate (8) were studied using washed rabbit platelets. Of the compounds tested, 6 showed potent antiplatelet effects on arachidonic acid (AA)-induced platelet aggregation (IC50 = 43.5 μM). The effect of 2, 5, and 6 on the contraction of rat thoracic aorta was also studied. Compound 6 depressed markedly the contraction induced by Ca2+ (1.9 mM) in high-K+ (80 mM) medium, with an IC50 of about 156 μM and also inhibited noradrenaline (3 μM)-induced phasic and tonic contractions, with an IC50 of about 68 and 72 μM, res...
54 citations