Isovitexin

About: Isovitexin is a research topic. Over the lifetime, 526 publications have been published within this topic receiving 11525 citations. The topic is also known as: 6-Glucosylapigenin & Isovitexin.

Brief review on medicinal potential of terminalia catappa

Abstract: Terminalia catappa Linn belongs to the family Combretaceae and is popularly known as 'deshi badam'. It is a well known herb in Ayurvedic system of medicine. Juice of young leaves are employed in preparation of ointment for leprosy, scabies and also used internally for colic and headache. Aqueous and ethanolic extracts of leaves were reported for their hepatoprotective activity. Reddish brown leaves contain flavonoid apigenin 6-c-(2 - galloyl)- L-Dglycoside, apigenin 8-c-(2 - galloyl)- L-D- glycoside, isovitexin, vitexin, isoorienthin, rutin and tannin ; gallic acid, ellagic acid, puricalagin, punicalin which are reported for good antioxidant property. Antidiabetic potential of T. catappa fruits has been investigated for its effect on fasting sugar level and serum parameters. More and more pharmacological studies have reported that the extract of T. cat appa leaves and fruits have anticancer, antioxidant, anti-HIV reverse transcriptase, anti-inflammatory, antidiabetic effects and hepatoprotective activities, but the effective components and related mechanisms remain unknown. Recently, data from our laboratory revealed that the chloroform fraction of the ethanol extract of T. cat appa leaves has the strongest anti-inflammatory activity among all fractions from ethanol extract of T. cat appa leaves.

Dominance Relationships between Two Allelic Genes Controlling Glycosyltransferases with Different Substrate Specificity in Melandrium

Abstract: Genetical analysis showed that the genes gG and gX, which control, respectively, the glucosylation and xylosylation of the 7-hydroxyl group of isovitexin in the petals of Melandrium, are alleles. In petal extracts of plants possessing the gene gX an enzyme was present which catalyzed the transfer of the xylose moiety of UDP-xylose to the 7-hydroxyl group of isovitexin. The xylosyl-transferase controlled by the gene gX had a "true Km value" of 0.77 mM for UDP-xylose. The "true Km value" for isovitexin was << 0.04 mM. The transfer of glucose from UDP-glucose to the 7-hydroxyl group of isovitexin is catalyzed by the enzyme controlled by gene gG. In plants possessing both the alleles gG and gX, only the gene product of gG, i.e., isovitexin 7-O-glucoside, was found. In this respect gG is dominant over allele gX. In petal extracts of these gGgX plants, however, besides UDP-glucose: isovitexin 7-O-glucosyltransferase, also UDP-xylose: isovitexin 7-O-xylosyltransferase could be detected. This means that the dominance is not a consequence of transcriptional and/or translational control. Enzyme kinetic experiments showed that inhibition of the xylosyltransferase by the endproduct of the glucosyltransferase did not occur. Comparison of the enzyme kinetic parameters revealed that the dominance is probably caused by differences in Vmax between the two enzymes, both working at saturating isovitexin concentrations. A competition model is suggested which explains why the amount of isovitexin 7-O-glucoside in gGgG plants and the amount of isovitexin 7-O-xyloside in gXgX plants are about the same, whereas in gGgX plants isovitexin 7-O-xyloside escapes detection. The differences in distribution of the isovitexin glycosylation genes in the two species M. album and M. dioicum are discussed.

Antioxidant and α-glucosidase inhibitory compounds from Pimpinella candolleana Wight et Arn.

Abstract: EtOAc and MeOH different extracts of Pimpinella candolleana Wight et Arn. have shown the α-glucosidase inhibitory and antioxidant activities when they were assayed in vitro. Chemical constituents of both extracts were isolated by column chromatography, and identified by MS and NMR spectroscopic data. Nine compounds were isolated, including 3 sterols, 2 flavones, 1 triterpene, 1 glucoside, 1 phenol derivatives, and 1 other compound. Their structures were identified as ursolic acid (1), luteolin (2), urea (3), stigmasta-5,22-dien-3-ol acetate (4), erythrol (5), isovitexin (6), 1-(4-hydroxyphenyl)-1,2-ethanediol (7), daucosterol (8), and β-sitosterol (9). Compound 1 (IC50 = 4.42 μg ml−1), 2 (IC50 = 5.96 μg ml−1), 4 (IC50 = 67.43 μg ml−1) and 6 (IC50 = 68.71 μg ml−1) showed α-glucosidase inhibitory activity. Compound 2 (IC50 = 0.99 μg ml−1) had antioxidant activity. All compounds except for 1 and 9 were isolated from this genus for the first time.

Flavonoid Analysis and Antioxidant Activities of the Bryonia alba L. Aerial Parts

Abstract: Bryonia alba L. is the only Bryonia species found in Romanian flora, being known as a remedy for inflammatory pathologies or for its hepatoprotective and adaptogen activities. The present investigation studied the flavonoid composition and antioxidant activities of the aerial parts of this species. Flavonoid profile was evaluated by HPLC coupled with Diode Array Detection (DAD), while antioxidant capacity was assessed by various methods, testing different antioxidant mechanisms: DPPH (2,2-diphenyl-1-picrylhydrazyl), CUPRAC (cupric reducing antioxidant capacity), FRAP (ferric reducing ability of plasma), TEAC (Trolox equivalent antioxidant capacity), EPR (electron paramagnetic resonance method) and SNPAC (silver nanoparticles antioxidant capacity). Cytotoxicity was tested on human cancerous and healthy cell lines. Anti-plasmodial tests were performed on two strains of Plasmodium falciparum. Whole organism toxicity was assessed on zebrafish larvae. The HPLC-DAD analysis proved the presence of lutonarin, saponarin, isoorientin, and isovitexin as the major flavonoids in the composition of tested samples. Significant results were obtained for all antioxidant capacity assays. The cytotoxicity tests proved the absence of cellular and parasitic toxicity and these results were confirmed by the lack of toxicity on the zebrafish larvae model. This study proves a promising potential of the aerial parts of Bryonia alba L. as antioxidant agents.