Topic
Keratan sulfate
About: Keratan sulfate is a research topic. Over the lifetime, 1253 publications have been published within this topic receiving 57984 citations. The topic is also known as: keratan sulfate & KS.
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TL;DR: The glycosaminoglycans which accumulate in greatly increased amounts in the liver were shown to contain galactose and glucosamine as the major carbohydrate constituents with a molar ratio of galactosidase to glucosamines greater than unity.
33 citations
TL;DR: The results are interpreted in relation to the structural and histochemical aspects of the cartilage layers; the significance of the observed heterogeneity of the chondroitin sulfate fraction and its possible relationship to differences in metabolism are discussed.
32 citations
TL;DR: In cartilage of patients with Morquio syndrome, a low expression of collagen type II and a high expression of gelatin type I both at protein and molecular levels are evidentiated, which could give evidence of the reduction in ankle and knee joint movement observable in these patients.
32 citations
TL;DR: Internal amino acid sequencing using nano-LC/MS/MS revealed that the salmon proteoglycan was aggrecan, and the ratio of serine attached to sugar chains was calculated to be approximately 37.7% of total serine, that is, 46 of 123 serine residues.
32 citations
TL;DR: Results indicate that modification of oligosaccharides in the aggrecan interglobular domain with keratan sulfate, most likely at asparagine residue 368, potentiates Aggrecanase activity in this part of the core protein.
32 citations