Topic
Keratan sulfate
About: Keratan sulfate is a research topic. Over the lifetime, 1253 publications have been published within this topic receiving 57984 citations. The topic is also known as: keratan sulfate & KS.
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TL;DR: It is proposed that corpora amylacea of the brain may result from accumulation of glycoconjugates normally present in the brain tissue matrix as the result of aging.
27 citations
TL;DR: The protein-keratan sulfate core of bovine nasal cartilage proteoglycan was purified by affinity chromatography on a column of immobilized hyaluronic acid using a hydrazido-alkyl derivative of Sepharose in the presence of borohydride to interact with the affinity matrix.
27 citations
TL;DR: Total and individual glycosaminoglycans were determined in rat cerebellum in tissue explants at various postnatal ages and all major GAGs showed the lowest incorporation values at adult ages.
Abstract: Total and individual glycosaminoglycans (GAGs) were determined in rat cerebellum in tissue explants at various postnatal ages. The major constituents of GAGs were chondroitin sulfate (CS), hyaluronic acid (HA), and heparan sulfate (HS). Dermatan sulfate (DS) and keratan sulfate (KS) could not be detected and therefore each amounts to less than 5% of all GAGs at all ages studied. HA was the prominent GAG during postnatal development and only a minor constituent at adult ages, whereas CS was the predominant GAG in adulthood. HS remained relatively constant throughout development. The incorporation of [3H]glucosamine into individual GAGs was highest for HS at postnatal day 6, whereas HA showed intermediate and CS the lowest levels of incorporation during the first postnatal week. All major GAGs showed the lowest incorporation values at adult ages.
27 citations
TL;DR: The content, types and the fine structures of proteoglycans (PGs) present in human normal nasal cartilage (HNNC) were investigated and compared with those in human scoliotic nasal Cartilage (HSNC).
27 citations
TL;DR: Investigation of KS expression in glioblastoma cell lines using Western-blot and flow cytometry with anti-KS antibody (5D4) and real-time PCR analysis showed that LN229 expresses a high level of keratan sulfate Gal-6-sulfotransferase, suggesting that Ln229 produces 5D4-reactive highly sulfated KS.
27 citations