Topic
Keratoderma
About: Keratoderma is a research topic. Over the lifetime, 956 publications have been published within this topic receiving 15025 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural disease, ker atoderma climactericum, further emphasize the importance of normal lipid synthesis in orderly cornification.
Abstract: A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural disease, keratoderma climactericum. These observations further emphasize the importance of normal lipid synthesis in orderly cornification.
28 citations
TL;DR: Direct sequencing of PCR products revealed a novel heterozygous 325A-->G mutation in the affected members of Pachyonychia congenita type 2 that predicts the substitution of asparagine by aspartic acid in codon 109 (N109D) located in the second half of the keratin 17 1A domain.
28 citations
TL;DR: The case of a patient with mal de Meleda with three unusual facultative features, i.e. prominent knuckle pads, peculiar finger-nail anomalies and pseudo-ainhum on both fifth fingers is reported.
Abstract: Mal de Meleda (keratoderma palmoplantaris transgrediens) is a rare autosomal recessive form of palmoplantar keratoderma characterized by hyperkeratosis of the palms and soles which appears soon after birth and progressively (progrediens) involves other areas (transgrediens) of the body skin. We report the case of a patient with mal de Meleda with three unusual facultative features, i.e. prominent knuckle pads, peculiar finger-nail anomalies and pseudo-ainhum on both fifth fingers. Four other members of the family are also affected by mal de Meleda.
28 citations
TL;DR: In this article, the authors reported that six patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex receiving intravenous infusions of soluble glucan (beta-1-3 polyglucose) developed a keratoderma of the palms and soles.
Abstract: Six of 20 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex receiving intravenous infusions of soluble glucan (beta-1-3 polyglucose) developed a keratoderma of the palms and soles. The eruption began during the first two weeks of therapy and resolved two to four weeks after its discontinuation. The eruption was different in appearance from our previously reported keratoderma blennorrhagica in AIDS-associated psoriasis. None of the other 735 patients with AIDS or AIDS-related complex not treated with soluble glucan developed a similar keratoderma. The correlation between receiving glucan and the hyperkeratosis is highly significant. Since glucan is a naturally occurring component of the cell walls of yeast, fungus, and some bacterial organisms, recognition of its ability to induce such a striking reaction pattern may be of general significance and interest, although the reaction itself may be limited to patients with AIDS.
28 citations
28 citations