Showing papers on "Koenigs–Knorr reaction published in 2001"
TL;DR: In this article, the preparation and application of anomeric glycosyl phosphinimides in preparative synthesis were studied, starting from the appropriate GAs and trialkyl or triaryl phosphines, the corresponding GAs were readily converted into 1- N -acyl-gluco- and galactopyranosyl amines with high yields by applying activated acid derivatives or simple carboxylic acids.
52 citations
TL;DR: Application of this methodology to a xylose-derived acylsilane led to the formation of difluoro-C-disaccharides as an isosteric O-glycosyl mimetic.
Abstract: Difluoroenoxysilanes, prepared from acylsilanes and trifluoromethyltrimethylsilane under fluoride activation, were glycosylated with some glycosyl donors (acylglycosides, glycals) to yield difluoro-C-glycosides with a difluoromethylene group in the place of the anomeric oxygen. This reaction strongly depends on the substituent in the 2-position of the glycosyl donor. Application of this methodology to a xylose-derived acylsilane led to the formation of difluoro-C-disaccharides as an isosteric O-glycosyl mimetic.
41 citations