scispace - formally typeset
Search or ask a question
Topic

Koenigs–Knorr reaction

About: Koenigs–Knorr reaction is a research topic. Over the lifetime, 106 publications have been published within this topic receiving 4521 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: In this article, the boron trichloride was used with dichloromethane solutions at −78 °C to give the corresponding glycosyl chlorides.

19 citations

Journal ArticleDOI
TL;DR: Various thioglycoside derivatives were obtained in high yields by one-pot fluoride-mediated de-silylation and thiol alkylation with alkyl halides or Michael acceptors of one common TIPS S-glycoside.
Abstract: Tri-isopropylsilyl thio-glycosides (TIPS S-glycosides) were synthesized through base promoted SN2 substitution of glycosyl halides with TIPS-SH or by Lewis acid promoted glycosylation of TIPS-SH with glycosyl acetates or p-methoxyphenyl glycosides. Various thioglycoside derivatives were obtained in high yields by one-pot fluoride-mediated de-silylation and thiol alkylation with alkyl halides or Michael acceptors of one common TIPS S-glycoside.

19 citations

Journal ArticleDOI
TL;DR: For example, the authors showed that reaction of the same nucleophilic derivatives with 2,3,4-tri-O -acetyl-α- l -fucopyranosyl bromide generally led to corresponding β- l-linked disaccharides.

18 citations

Journal ArticleDOI
TL;DR: Several improved approaches for the preparation of tetra-O-benzyl-α-D-glucopyranosyl bromide and tetra O-pivaloyl-α,D-GLUCOPYRANOSYL Bromide are discussed in this article.
Abstract: Several improved approaches for the preparation of tetra-O-benzyl-α-D-glucopyranosyl bromide and tetra-O-pivaloyl-α-D-glucopyranosyl bromide are discussed. The importance of these compounds, which are useful glycosyl donors, was demonstrated by successful preparation of cholesteryl glucopyranosides in an almost neutral medium without the formation of orthoesters. In addition, accurate 1H and 13C NMR resonance assignments of the synthesized cholesteryl glycosides were performed by 2D NMR spectroscopy.

17 citations

Journal ArticleDOI
TL;DR: In this paper, a straightforward procedure is described for the synthesis of (16)-linked saccharides by regioselective glycosylation of unprotected glycosynyl acceptors.

17 citations

Network Information
Related Topics (5)
Regioselectivity
22.4K papers, 465.9K citations
80% related
Aryl
95.6K papers, 1.3M citations
79% related
Nucleophile
30.8K papers, 602.8K citations
79% related
Aldehyde
29K papers, 479.2K citations
78% related
Enantioselective synthesis
58.1K papers, 1.6M citations
77% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20191
20172
20161
20151
20141
20136