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Lanosterol

About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.


Papers
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Journal ArticleDOI
TL;DR: It is shown that these compounds lower ergosterol levels in the fungal cells and probably act by targeting lanosterol 14α-demethylase, a key enzyme in the sterol biosynthetic pathway of C. albicans.

22 citations

Journal ArticleDOI
TL;DR: The results suggest that the C-7 hydrogen atoms with opposite stereochemistry are labilized by the rat liver and the yeast Delta(8)-Delta(7) steroid isomerases.
Abstract: The synthesis of [7α-3H]lanosterol is described. It is shown that in the conversion of [7α-3H,26,27-14C2]lanosterol into cholesterol by a rat liver system, it is the 7β-hydrogen atom that is predominantly removed. On the other hand, the conversion of doubly labelled lanosterol into ergosterol by whole yeast cells results in the loss of the 7α-hydrogen atom. These results therefore suggest that the C-7 hydrogen atoms with opposite stereochemistry are labilized by the rat liver and the yeast Δ8–Δ7 steroid isomerases.

22 citations

Book ChapterDOI
01 Jan 1990
TL;DR: The conversion of squalene to 2,3-oxidosqualene is now known to be converted by a two-step sequence of epoxidation and subsequent cyclisation involving two separate enzymes.
Abstract: Squalene occupies a key position in the biosynthetic sequence from acetate to ergosterol (Fig. 1), being the first lipophilic intermediate in the pathway. The conversion of this 30-carbon hydrocarbon to the tetracyclic lanosterol structure was originally thought to occur in one step without intermediates. Tchen and Bloch (1957) showed that rat liver extracts require oxygen and reduced pyridine nucleotide to perform cyclisation of squalene. Yeast cells were also shown to require oxygen for ergosterol biosynthesis (Andreasen and Stier 1953) and to accumulate squalene under anaerobic conditions (Klein 1955). Subsequently, the intermediate 2,3-oxidosqualene was discovered (Corey et al. 1966; Van Tamelen et al. 1966) and squalene is now known to be converted by a two-step sequence of epoxidation and subsequent cyclisation involving two separate enzymes. The first of these enzymes, squalene epoxidase (EC 1.14.99.7), was initially described by Yamamoto and Bloch (1970) using rat liver extracts.

22 citations

Journal ArticleDOI
TL;DR: It is shown that significantly more endogenously generated NADPH is available for reduction of corticosterone in liver homogenates from C57BL/10 male mice than in those from the DBA/2 strain, which mainly produces lanosterol and other precursors of cholesterol which require NADPH for their further metabolism.

22 citations

Journal ArticleDOI
TL;DR: It is suggested that the cholesterol concentration in the culture medium influences the rate of sterol formation by the kidney cell, and cholesterol appears to be essential to cultured human kidney and de novo synthesis by the cells in culture is not adequate to meet their requirements for growth.

22 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202331
202261
202120
202023
201914
201822