Topic
Lanosterol
About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.
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TL;DR: The incorporation of mevalonic acid-2- 14 C into cut flower stalks of Taraxacum officinale L, whose principal sterol and triterpene respectively in the dried form is β-sitosterol and β-amyrin, was studied at intervals of 0·5 hr to 2 weeks as discussed by the authors.
20 citations
TL;DR: Observations indicate that the 14 alpha-demethylation of lanosterol by yeast microsomes occurs sequentially via the Trienol, and reduction of the trienol to 4,4-dimethylzymosterol is mediated by an AY-9944-sensitive reductase.
20 citations
TL;DR: It is concluded that cholesterol and ergosterol have identical precursor in the early stages of their biosynthesis and that acetate, squalene, and lanosterol are among these precursors.
20 citations
TL;DR: Stereoselective synthesis of the potentially biologically valuable 5beta-lanosteroidal-type backbone was achieved via anionic cycloaddition and the two new bicyclic Nazarov intermediates 14 and 40 could lead to the total synthesis of new lanosterol-based inhibitors.
Abstract: Stereoselective synthesis of the potentially biologically valuable 5β-lanosteroidal-type backbone was achieved via anionic cycloaddition. Synthesis of the two new bicyclic Nazarov intermediates 14 and 40 and their cycloaddition with chiral cyclohexenone 25 and further functional group manipulations resulted in highly functionalized tetracyclic intermediates 28 and 44. These synthetic intermediates could lead to the total synthesis of new lanosterol-based inhibitors.
20 citations