Topic
Lanosterol
About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.
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TL;DR: In higher organisms, this pathway is primarily restricted to the liver, small intestine, kidney, and endocrine organs, while other classes of cells do maintain the enzymes for this set of reactions, they depend upon the liver as a source of sterol.
Abstract: Publisher Summary This chapter discusses the pathway of cholesterol biosynthesis. The pathway is divided into segments that correspond to the chemical and biochemical divisions of biosynthetic route. The initial part of the pathway is the three-step conversion of acetyl-CoA to 3-hydroxy-3-methylglutaryl-Co(HMG-CoA). The next is the reduction of this molecule to mevalonate, considered to be the rate-controlling step in the biosynthesis of polyisoprenoids. Thence, a series of phosphorylation reactions both activate and decarboxylate mevalonate to isopentenyl pyrophosphate, the true isoprenoid precursor. After a rearrangement to the allylic pyrophosphate, dimethylallyl pyrophosphate, a sequence of 1'-4 condensations between the allylic and homoallylic pyrophosphates leads to the synthesis of prenyl pyrophosphates that are requisite for the synthesis of the higher polyprenols, such as cholesterol, dolichol, and coenzyme Q. For the synthesis of cholesterol, the polymerization is halted at the sesquiterpene level. Two molecules of the farnesyl pyrophosphate thus formed condense in head-to-head producing presqualene pyrophosphate. After a reductive rearrangement of the carbon skeleton to squalene, an epoxidation leads to the formation of 2,3-oxidosqualene, which then cyclizes to lanosterol. The final stages of sterologenesis involve the removal of three methyl groups from lanosterol and the migration and reduction of double bonds to give cholesterol. In higher organisms, this pathway is primarily restricted to the liver, small intestine, kidney, and endocrine organs. While other classes of cells do maintain the enzymes for this set of reactions, they depend upon the liver as a source of sterol.
10 citations
Journal Article•
10 citations
TL;DR: In this article, evidence is presented that is consistent with cucurbitacin B being biosynthesized via cycloartenol or parkeol but not through the intermediacy of lanosterol.
Abstract: Evidence is presented that is consistent with cucurbitacin B being biosynthesized via cycloartenol or parkeol but not through the intermediacy of lanosterol.
10 citations
TL;DR: An inhibition of the cholesterol synthesis by a lipogenic diet in rat liver is described and could be shown with glucose or mevalonate as tracer substances with no indication for any other inhibiting effect was obtained.
9 citations
TL;DR: It is concluded that the increased rate and extent of [14C]acetate accumulation into the sterols and squalene reflects an increased rate of synthesis of these compounds.
9 citations