Topic
Lanosterol
About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.
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TL;DR: Gas—liquid chromatography and gas chromatography—mass spectrometry have been used to study the pattern of sterols in meconium and faeces from newborn infants.
Abstract: Gas—liquid chromatography and gas chromatography—mass spectrometry have been used to study the pattern of sterols in meconium and faeces from newborn infants. Meconium contained metabolites from various steps in the biosynthesis of cholesterol, e. g. lanosterol, 24, 25-dihydro-∆ 8 -lanosterol, 24, 25-dihydro-∆ 9 -lanosterol, 4 α ,14 α -dimethyl-5 α -cholest-7 (and 8)-en-3 β -ol, 4, 4-dimethyl-5 α -cholest-8-en-3 β -ol, 4, 4-dimethyl-5 α -cholesta-8, 14-dien-3 β -ol and ∆ 7 - and ∆ 8 -methostenol. Meconium and faeces from newborns also contained the sulphate esters of 20, 22-dihydroxycholesterol and of 22-, 23- and 24-hydroxycholesterol.
8 citations
TL;DR: Both types of platelets showed a significant increase in ADP-induced aggregation and in binding of fibrinogen, indicating that the effect of oral contraceptives could be partly due to increased levels of lanosterol in platelet membrane.
8 citations
TL;DR: Four non-azole inhibitors of lanosterol 14a-demethylase in Candida albicans CCH442 demonstrated broad in-vitro antifungal activity against several Candida species as well as against Cryptococcus albidus and Aspergillus niger.
Abstract: We have identified four non-azole inhibitors of lanosterol 14a-demethylase in Candida albicans CCH442. The most potent compound, A-39806, had IC50 values for ergosterol inhibition of 0.9 microM (0.3 mg/L) and 1.9 microM (0.6 mg/L) in whole cell and cell-free extract assays, respectively. A-39806 demonstrated broad in-vitro antifungal activity against several Candida species as well as against Cryptococcus albidus and Aspergillus niger. In-vitro antifungal activity was also demonstrated against a fluconazole-resistant clinical isolate of C. albicans.
8 citations
TL;DR: The evolution throughout embryonic development of the rate at which acetate was converted into sterols was studied in chick brain and liver, and cholesterol and desmosterol were the major sterols formed by chick embryo brain, followed by lanosterol and squalene.
7 citations
TL;DR: The direct one-step assay of oxidase activity with the model 4-hydroxy[14C]methylene sterol substrate is rapid, the observed rates are rapid, and the enzymic steps in the multienzymic, mixed function oxidase may be elucidated with this simplified procedure.
7 citations