Lanosterol

About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.

Synthesis of lanosterol derivatives with a functional group at C-32, including an antineoplastic sterol, 3 beta-hydroxylanost-7-en-32-oic acid.

Abstract: Lanosterol derivatives with a functional group at C-32 have been synthesized from 3 beta-acetoxylanostan-7 alpha-ol. The key reaction of the synthesis is the hypoiodite reaction of 3 beta-acetoxylanostan-7 alpha-ol. In vitro antitumor activity testing of the lanosterol derivatives revealed that 3 beta-hydroxylanost-7-en-32-oic acid has antineoplastic activity.

Pressure Perturbation Calorimetric Studies on Phospholipid-Sterol Mixtures

Abstract: Sterols regulate biological processes and sustain the lateral structure of cellular membranes. The sterol cholesterol, its precursor lanosterol, the plant sterols stigmasterol and ergosterol as well as 7-dehydrocholesterol were added up to 36 mol-% to vesicles of the phospholipid 1,2-dipalmitoyl-snglycero-3-phosphatidylcholine (DPPC). The aim of this study was to investigate the influence of the sterol side chain and ring structure on the volumetric properties of the lipid bilayer system by using pressure perturbation calorimetry (PPC), a relatively new and efficient technique, to study the thermal expansion coefficient and volumetric properties of biomolecules. The experiments were carried out in the temperature range from 10 to 85 ◦ C, i. e., at temperatures below and above the chain-melting transition temperatures of the lipid mixtures. Additionally, corresponding differential scanning calorimetric (DSC) measurements were carried out. Whereas the conformational properties of the different sterols have a significant effect on the order parameter of the lipid acyl-chains, the thermodynamic parameters of these sterols are less influenced by the differential structural changes of the sterols. For lanosterol and stigmasterol, marked differences are found, however.

Role of Membrane Sterols in Mycoplasma capricolum

Abstract: A low level of cholesterol in lanosterol-rich membranes of Mycoplasma capricolum exerts a synergistic effect on growth while leaving the bulk physical state of the membrane unchanged. This observation has led to the proposal that cholesterol may serve a dual role in membranes: one as a bulk component and another of a more specialized nature involving cholesterol-specific interactions. Lanosterol, while competent as a bulk membrane sterol, cannot effectively perform the second function. The fact that a low level of cholesterol in lanosterol-rich cells specifically alters the ability of these cells to incorporate unsaturated fatty acids suggests that this more specialized role for cholesterol may be concerned with fatty acid transport or phospholipid biosynthesis.