Topic
Lanosterol
About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.
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TL;DR: The C-18 methyl peak of obliquol diacetate has shifted downfield from the corresponding peak in lanosterol acetate due to perturbation by the 12-acetyl group, and it was concluded that ob liquol has the structure I.
5 citations
5 citations
Patent•
24 Jan 2002
TL;DR: In this article, a cholesterol-lowering agent rich in natural oxygenated lanosterol derivatives originating from edible mushrooms was proposed, such an agent can be added to food products.
Abstract: The invention relates to a cholesterol-lowering agent rich in natural oxygenated lanosterol derivatives originating from edible mushrooms. Such an agent can be added to food products. The invention also relates to a method for producing one such agent.
5 citations
TL;DR: Incubation of CHO-K1 cells in lipid-deficient medium containing lanosterol for 4 days was associated with a profound change in cellular sterol composition as reflected by a marked accumulation of lanosterols and 24,25-dihydrolanosterol and a striking elongation of the cells.
4 citations
TL;DR: Lanosterol was obtained by adding SSF-109, a sterol biosynthesis inhibitor, to the hepatocytes suspension and the proton-decoupled 13C–1H COSY spectrum confirmed the stereospecific hydrogen attack at C-7, C-15 and C-24.
Abstract: Since isolated dog hepatocytes have been shown to exhibit potent activity for the synthesis of cholesterol from acetic acid, an analysis of cholesterol and lanosterol biosynthesized from [1,2-13C2]- or [2-13C2H3] acetate in fresh isolated hepatocytes has been attempted in order to clarify the incorporation and distribution of the acetate carbon and hydrogen into these sterols. Lanosterol was obtained by adding SSF-109, a sterol biosynthesis inhibitor, to the hepatocytes suspension. 13C NMR spectroscopic analysis of the [13C]- and [13C2H]-labelling patterns of these compounds confirmed the following: (i) the involvement of two 1,2-hydride shifts, 20-H from C-17 and 17-H from C-13; (ii) two 1,2-methyl migrations, 13-methyl group (C-18) from C-14 and 14-methyl group (C-32) from C-8 in the cyclization of 2,3-oxidosqualene to form lanosterol; and (iii) stereospecific hydrogenation from the Si-face at C-25 in the conversion of lanosterol into cholesterol. The proton-decoupled 13C–1H COSY spectrum confirmed the stereospecific hydrogen attack at C-7, C-15 and C-24. The deuterium atoms of [1-2H2]ethanol were incorporated into lanosterol at C-2, C-6, C-11, C-12, C-16 and C-23, which arise from C-5 of mevalonic acid.
4 citations