Topic
Lanosterol
About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.
Papers published on a yearly basis
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TL;DR: A quantitative study of the specific inhibitory power of cholesterol and other sterols on the hemolytic properties of streptolysin O is reported and the mechanism of biomembrane disorganization by streptococcal exocellular protein is discussed in the light of its steroid binding properties.
90 citations
TL;DR: 24,25-epoxylanosterol per se was not an inhibitor of reductase activity but could be metabolized to regulatory polar sterols through a cytochrome P-450 dependent reaction which was sensitive to ketoconazole.
90 citations
89 citations
TL;DR: Cyp51 knock-out mice provide evidence that Cyp51 is essential for embryogenesis and present a potential animal model for studying ABS syndrome in humans.
89 citations
TL;DR: It is concluded that the cytochrome P-450-containing monooxygenase system of yeast microsomes catalyzes the 14α-demethylation of lanosterol.
89 citations