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Lanosterol

About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.


Papers
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Journal ArticleDOI
TL;DR: The data indicate that fungicide residues in food are unlikely to exert a relevant inhibition of CYP51 in humans whereas systemic use of some antimycotic drugs, e.g. ketoconazole or miconazole, should be carefully considered regarding disturbance of human steroid biosynthesis.

75 citations

Journal ArticleDOI
TL;DR: This method is suitable for studies on the effect of different inhibitors and stimulators of cholesterol synthesis in cultured cells and is relevant also for clinical applications since abnormally increased late cholesterol intermediates in patients are representations of the inherited disorders linked to different enzyme defects in the post-squalene cholesterol biosynthesis.

75 citations

Journal ArticleDOI
TL;DR: The cloning and characterization of the human gene (OSC) encoding lanosterol synthase, a predicted 83 kDa protein of 732 amino acids, is reported herein, and the deduced amino acid sequence is 36-40% identical to known yeast and plant homologues and 83% similar to Rattus norvegicus lanosterl synthase.

75 citations

Journal ArticleDOI
TL;DR: It is suggested that cycloartenol may replace lanosterol as an intermediate in the biosynthesis of phytosterols in tobacco tissue cultures.

74 citations

Journal ArticleDOI
TL;DR: Hepatitis C virus G3, but not G2, selectively interferes with the late cholesterol synthesis pathway, evidenced by lower distal sterol metabolites and preserved lanosterol levels, which may explain why hypocholesterolemia persists in chronic HCV infection, and is not overcome by host cholesterol compensatory mechanisms.

74 citations


Network Information
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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202331
202261
202120
202023
201914
201822