Topic
Lanosterol
About: Lanosterol is a research topic. Over the lifetime, 1239 publications have been published within this topic receiving 36737 citations. The topic is also known as: (3β)-lanosta-8,24-dien-3-ol & (3β,20R)-lanosta-8,24-dien-3-ol.
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TL;DR: (3S)-2, 3-Epoxy-2,3-dihydrosqualene has been shown to be the precursor of lanosterol in pig liver, of Lanosterol and ergosterolIn yeast, and of cycloartenol, β-amyrin, and lupeol in germinating pea seedlings.
Abstract: (3S)-2,3-Epoxy-2,3-dihydrosqualene has been shown to be the precursor of lanosterol in pig liver, of lanosterol and ergosterol in yeast, and of cycloartenol, β-amyrin, and lupeol in germinating pea seedlings.
37 citations
TL;DR: Ab initio calculations were performed on a cyclohexane derivative to elucidate the mechanism of the formation of the five-membered C ring in the biosynthesis of lanosterol from squalene and indicated that the conformer that should give rise to the cyclized C ring is not a minimum on the potential surface.
37 citations
TL;DR: An improved three‐dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand‐supported homology modeling and molecular dynamics simulations, and it performed better than the previous CacyP51 model.
Abstract: Lanosterol 14alpha-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed model was evaluated by its performance in a small-scale virtual screen. The results show that known CYP51 inhibitors were efficiently discriminated by the model, and it performed better than our previous CACYP51 model. The active site of CACYP51 was characterized by multiple copy simultaneous search (MCSS) calculations. On the basis of the MCSS results, a series of novel azoles were designed and synthesized, and they showed good in vitro antifungal activity with a broad spectrum. The MIC(80) value of four of these compounds against C. albicans is 0.001 microg mL(-1), indicating that they are promising leads for the discovery of novel antifungal agents.
37 citations
37 citations
TL;DR: Pig and rat liver oxidosqualene cyclase (OSC) enzymes were purified to homogeneity and showed single bands on SDS-polyacrylamide gel electrophoresis with molecular masses of 75 kDa and 78 kDa, demonstrating subtle differences in the active sites of animal, plant, and fungal enzymes.
37 citations