Showing papers on "Laser published in 2001"
TL;DR: Room-temperature ultraviolet lasing in semiconductor nanowire arrays has been demonstrated and self-organized, <0001> oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process.
Abstract: Room-temperature ultraviolet lasing in semiconductor nanowire arrays has been demonstrated The self-organized, oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process These wide band-gap semiconductor nanowires form natural laser cavities with diameters varying from 20 to 150 nanometers and lengths up to 10 micrometers Under optical excitation, surface-emitting lasing action was observed at 385 nanometers, with an emission linewidth less than 03 nanometer The chemical flexibility and the one-dimensionality of the nanowires make them ideal miniaturized laser light sources These short-wavelength nanolasers could have myriad applications, including optical computing, information storage, and microanalysis
8,592 citations
TL;DR: A theoretical model is presented that reveals that the system is self-adjusting to minimize dissipative loss during the ‘read’ and ‘write’ operations, anticipating applications of this phenomenon for quantum information processing.
Abstract: Electromagnetically induced transparency1,2,3 is a quantum interference effect that permits the propagation of light through an otherwise opaque atomic medium; a ‘coupling’ laser is used to create the interference necessary to allow the transmission of resonant pulses from a ‘probe’ laser. This technique has been used4,5,6 to slow and spatially compress light pulses by seven orders of magnitude, resulting in their complete localization and containment within an atomic cloud4. Here we use electromagnetically induced transparency to bring laser pulses to a complete stop in a magnetically trapped, cold cloud of sodium atoms. Within the spatially localized pulse region, the atoms are in a superposition state determined by the amplitudes and phases of the coupling and probe laser fields. Upon sudden turn-off of the coupling laser, the compressed probe pulse is effectively stopped; coherent information initially contained in the laser fields is ‘frozen’ in the atomic medium for up to 1 ms. The coupling laser is turned back on at a later time and the probe pulse is regenerated: the stored coherence is read out and transferred back into the radiation field. We present a theoretical model that reveals that the system is self-adjusting to minimize dissipative loss during the ‘read’ and ‘write’ operations. We anticipate applications of this phenomenon for quantum information processing.
1,902 citations
TL;DR: An intense proton beam to achieve fast ignition is proposed, produced by direct laser acceleration and focused onto the pellet from the rear side of an irradiated target and can be integrated into a hohlraum for indirect drive ICF.
Abstract: The concept of fast ignition with inertial confinement fusion (ICF) is a way to reduce the energy required for ignition and burn and to maximize the gain produced by a single implosion. Based on recent experimental findings at the PETAWATT laser at Lawrence Livermore National Laboratory, an intense proton beam to achieve fast ignition is proposed. It is produced by direct laser acceleration and focused onto the pellet from the rear side of an irradiated target and can be integrated into a hohlraum for indirect drive ICF.
1,171 citations
TL;DR: Measurements of the threshold for structural change in Corning 0211 glass are presented as well as a study of the morphology of the structures produced by single and multiple laser pulses.
Abstract: Using tightly focused femtosecond laser pulses of just 5 nJ, we produce optical breakdown and structural change in bulk transparent materials and demonstrate micromachining of transparent materials by use of unamplified lasers. We present measurements of the threshold for structural change in Corning 0211 glass as well as a study of the morphology of the structures produced by single and multiple laser pulses. At a high repetition rate, multiple pulses produce a structural change dominated by cumulative heating of the material by successive laser pulses. Using this cumulative heating effect, we write single-mode optical waveguides inside bulk glass, using only a laser oscillator.
792 citations
TL;DR: In this paper, the authors present a method for measuring the threshold intensity required to produce breakdown and damage in the bulk, as opposed to on the surface, of the material, and determine the relative role of different nonlinear ionization mechanisms for different laser and material parameters.
Abstract: Laser-induced breakdown and damage to transparent materials has remained an active area of research for four decades. In this paper we review the basic mechanisms that lead to laser-induced breakdown and damage and present a summary of some open questions in the field. We present a method for measuring the threshold intensity required to produce breakdown and damage in the bulk, as opposed to on the surface, of the material. Using this technique, we measure the material band-gap and laser-wavelength dependence of the threshold intensity for bulk damage using femtosecond laser pulses. Based on these thresholds, we determine the relative role of different nonlinear ionization mechanisms for different laser and material parameters.
747 citations
TL;DR: An all-optical atomic clock referenced to the 1.064-petahertz transition of a single trapped199Hg+ ion is demonstrated and an upper limit for the fractional frequency instability of 7 × 10−15 is measured in 1 second of averaging—a value substantially better than that of the world's best microwave atomic clocks.
Abstract: Microwave atomic clocks have been the de facto standards for precision time and frequency metrology over the past 50 years, finding widespread use in basic scientific studies, communications, and navigation. However, with its higher operating frequency, an atomic clock based on an optical transition can be much more stable. We demonstrate an all-optical atomic clock referenced to the 1.064-petahertz transition of a single trapped 199Hg+ ion. A clockwork based on a mode-locked femtosecond laser provides output pulses at a 1-gigahertz rate that are phase-coherently locked to the optical frequency. By comparison to a laser-cooled calcium optical standard, an upper limit for the fractional frequency instability of 7 x 10(-15) is measured in 1 second of averaging-a value substantially better than that of the world's best microwave atomic clocks.
695 citations
TL;DR: This technique allows fabrication of 3-D channels as small as 10mum in diameter inside the volume with any angle of interconnection and a high aspect ratio.
Abstract: We demonstrate direct three-dimensional (3-D) microfabrication inside a volume of silica glass. The whole fabrication process was carried out in two steps: (i) writing of the preprogrammed 3-D pattern inside silica glass by focused femtosecond (fs) laser pulses and (ii) etching of the written structure in a 5% aqueous solution of HF acid. This technique allows fabrication of 3-D channels as small as 10 μm in diameter inside the volume with any angle of interconnection and a high aspect ratio (10‐μm-diameter channels in a 100‐μm-thick silica slab).
668 citations
TL;DR: In this article, a detailed review of the performance of quantum cascade (QC) laser can be found, where the inter-subband transition is characterized through ultrafast carrier dynamics and the absence of the linewidth enhancement factor, with both features expected to have significant impact on laser performance.
Abstract: Quantum cascade (`QC') lasers are reviewed. These are semiconductor injection lasers based on intersubband transitions in a multiple-quantum-well (QW) heterostructure, designed by means of band-structure engineering and grown by molecular beam epitaxy. The intersubband nature of the optical transition has several key advantages. First, the emission wavelength is primarily a function of the QW thickness. This characteristic allows choosing well-understood and reliable semiconductors for the generation of light in a wavelength range unrelated to the material's energy bandgap. Second, a cascade process in which multiple - often several tens of - photons are generated per electron becomes feasible, as the electron remains inside the conduction band throughout its traversal of the active region. This cascading process is behind the intrinsic high-power capabilities of the lasers. Finally, intersubband transitions are characterized through an ultrafast carrier dynamics and the absence of the linewidth enhancement factor, with both features being expected to have significant impact on laser performance. The first experimental demonstration by Faist et al in 1994 described a QC-laser emitting at 4.3 µm wavelength at cryogenic temperatures only. Since then, the lasers' performance has greatly improved, including operation spanning the mid- to far-infrared wavelength range from 3.5 to 24 µm, peak power levels in the Watt range and above-room-temperature (RT) pulsed operation for wavelengths from 4.5 to 16 µm. Three distinct designs of the active region, the so-called `vertical' and `diagonal' transition as well as the `superlattice' active regions, respectively, have emerged, and are used either with conventional dielectric or surface-plasmon waveguides. Fabricated as distributed feedback lasers they provide continuously tunable single-mode emission in the mid-infrared wavelength range. This feature together with the high optical peak power and RT operation makes QC-lasers a prime choice for narrow-band light sources in mid-infrared trace gas sensing applications. Finally, a manifestation of the high-speed capabilities can be seen in actively and passively mode-locked QC-lasers, where pulses as short as a few picoseconds with a repetition rate around 10 GHz have been measured.
637 citations
TL;DR: The authors' techniques for generation and measurement offer sub-femtosecond resolution over a wide range of x-ray wavelengths, paving the way to experimental attosecond science and tracing atomic processes evolving faster than the exciting light field is within reach.
Abstract: Single soft-x-ray pulses of approximately 90-electron volt (eV) photon energy are produced by high-order harmonic generation with 7-femtosecond (fs), 770-nanometer (1.6 eV) laser pulses and are characterized by photoionizing krypton in the presence of the driver laser pulse. By detecting photoelectrons ejected perpendicularly to the laser polarization, broadening of the photoelectron spectrum due to absorption and emission of laser photons is suppressed, permitting the observation of a laser-induced downshift of the energy spectrum with sub-laser-cycle resolution in a cross correlation measurement. We measure isolated x-ray pulses of 1.8 (+0.7/-1.2) fs in duration, which are shorter than the oscillation cycle of the driving laser light (2.6 fs). Our techniques for generation and measurement offer sub-femtosecond resolution over a wide range of x-ray wavelengths, paving the way to experimental attosecond science. Tracing atomic processes evolving faster than the exciting light field is within reach.
636 citations
TL;DR: In this paper, the self-organized, oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process, and they formed natural laser cavities with diameters varying from 20 to 150 nanometers and lengths up to 10 micrometers.
Abstract: Room-temperature ultraviolet lasing in semiconductor nanowire arrays has been demonstrated. The self-organized, oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process. These wide band-gap semiconductor nanowires form natural laser cavities with diameters varying from 20 to 150 nanometers and lengths up to 10 micrometers. Under optical excitation, surface-emitting lasing action was observed at 385 nanometers, with an emission linewidth less than 0.3 nanometer. The chemical flexibility and the one-dimensionality of the nanowires make them ideal miniaturized laser light sources. These short-wavelength nanolasers could have myriad applications, including optical computing, information storage, and microanalysis.
632 citations
TL;DR: Polarization mode selection in a two-dimensional (2D) photonic crystal laser is demonstrated by controlling the geometry of the unit cell structure by observing coherent lasing action with a single wavelength and controlled polarization in good agreement with the predicted behavior.
Abstract: We demonstrate polarization mode selection in a two-dimensional (2D) photonic crystal laser by controlling the geometry of the unit cell structure. As the band diagram of the square-lattice photonic crystal is influenced by the unit cell structure, calculations reveal that changing the structure from a circular to an elliptical geometry should result in a strong modification of the electromagnetic field distributions at the band edges. Such a structural modification is expected to provide a mechanism for controlling the polarization modes of the emitted light. A square-lattice photonic crystal with the elliptical unit cell structure has been fabricated and integrated with a gain media. The observed coherent 2D lasing action with a single wavelength and controlled polarization is in good agreement with the predicted behavior.
TL;DR: Here, a technique that does not require phase stabilization is used to demonstrate experimentally the influence of the absolute phase of a short laser pulse on the emission of photoelectrons.
Abstract: Currently, the shortest laser pulses1 that can be generated in the visible spectrum consist of fewer than two optical cycles (measured at the full-width at half-maximum of the pulse's envelope). The time variation of the electric field in such a pulse depends on the phase of the carrier frequency with respect to the envelope—the absolute phase. Because intense laser–matter interactions generally depend on the electric field of the pulse, the absolute phase is important for a number of nonlinear processes2,3,4,5,6,7,8. But clear evidence of absolute-phase effects has yet to be detected experimentally, largely because of the difficulty of stabilizing the absolute phase in powerful laser pulses. Here we use a technique that does not require phase stabilization to demonstrate experimentally the influence of the absolute phase of a short laser pulse on the emission of photoelectrons. Atoms are ionized by a short laser pulse, and the photoelectrons are recorded with two opposing detectors in a plane perpendicular to the laser beam. We detect an anticorrelation in the shot-to-shot analysis of the electron yield.
TL;DR: By observing the interference pattern of atoms released from more than 3000 individual lattice tubes, the phase coherence of the coupled quantum gases is studied and the lifetime of the condensate in the lattice and the dependence of the interference patterns on the lattices configuration are investigated.
Abstract: Bose-Einstein condensates of rubidium atoms are stored in a two-dimensional periodic dipole force potential, formed by a pair of standing wave laser fields. The resulting potential consists of a lattice of tightly confining tubes, each filled with a 1D quantum gas. Tunnel coupling between neighboring tubes is controlled by the intensity of the laser fields. By observing the interference pattern of atoms released from more than 3000 individual lattice tubes, the phase coherence of the coupled quantum gases is studied. The lifetime of the condensate in the lattice and the dependence of the interference pattern on the lattice configuration are investigated.
TL;DR: In this paper, the mechanism of ablation of solids by femtosecond laser pulses is described in an explicit analytical form and the formulae for ablation thresholds and ablation rates for metals and dielectrics, combining the laser and target parameters, are derived and compared to experimental data.
Abstract: The mechanism of ablation of solids by intense femtosecond laser pulses is described in an explicit analytical form. It is shown that at high intensities when the ionization of the target material is complete before the end of the pulse, the ablation mechanism is the same for both metals and dielectrics. The physics of this new ablation regime involves ion acceleration in the electrostatic field caused by charge separation created by energetic electrons escaping from the target. The formulae for ablation thresholds and ablation rates for metals and dielectrics, combining the laser and target parameters, are derived and compared to experimental data. The calculated dependence of the ablation thresholds on the pulse duration is in agreement with the experimental data in a femtosecond range, and it is linked to the dependence for nanosecond pulses.
TL;DR: Spectra extending from 600 to 1200 nm have been generated from a Kerr-lens mode-locked Ti:sapphire laser producing 5-fs pulses, to the authors' knowledge the broadest ever generated directly from a laser oscillator.
Abstract: Spectra extending from 600 to 1200 nm have been generated from a Kerr-lens mode-locked Ti:sapphire laser producing 5-fs pulses. Specially designed double-chirped mirror pairs provide broadband controlled dispersion, and a second intracavity focus in a glass plate provides additional spectral broadening. These spectra are to our knowledge the broadest ever generated directly from a laser oscillator.
TL;DR: In this article, ultraviolet lasing from single zinc oxide nanowires is demonstrated at room temperature, and near-field optical microscopy images quantify the localization and divergence of the laser beam.
Abstract: Ultraviolet lasing from single zinc oxide nanowires is demonstrated at room temperature. Near-field optical microscopy images quantify the localization and the divergence of the laser beam. The linewidths, wavelengths, and power dependence of the nanowire emission characterize the nanowire as an active optical cavity. These individual nanolasers could serve as miniaturized light sources for microanalysis, information storage, and optical computing.
TL;DR: Using in situ Raman scattering in a confocal microscopy setup, changes in the network structure of fused silica after modifying regions inside the glass with tightly focused 800-nm 130-fs laser pulses are observed.
Abstract: Using in situ Raman scattering in a confocal microscopy setup, we have observed changes in the network structure of fused silica after modifying regions inside the glass with tightly focused 800-nm 130-fs laser pulses at fluences of 5–200 J cm-2 The Raman spectra show a large increase in the peaks at 490 and 605 cm-1, owing to 4- and 3-membered ring structures in the silica network, indicating that densification occurs after exposure to the femtosecond laser pulses The results are consistent with the formation of a localized plasma by the laser pulse and a subsequent microexplosion inside the glass
TL;DR: The results give evidence for subnanosecond coupling-induced synchronized chaotic dynamics in conjunction with a spontaneous symmetry-breaking, and a well-defined time lag between the dynamics of the two lasers, and an asymmetric physical role of the subsystems.
Abstract: We present experimental and numerical investigations of the dynamics of two device-identical, optically coupled semiconductor lasers exhibiting a delay in the coupling. Our results give evidence for subnanosecond coupling-induced synchronized chaotic dynamics in conjunction with a spontaneous symmetry-breaking: we find a well-defined time lag between the dynamics of the two lasers, and an asymmetric physical role of the subsystems. We demonstrate that the leading laser synchronizes its lagging counterpart, whereas the synchronized lagging laser drives the coupling-induced instabilities.
TL;DR: A directional coupler written in a glass sample by the focused 400-nm output from a 25-fs oscillator is reported; the coupler is single mode; the splitting ratio is 1.9 dB at 633 nm.
Abstract: A directional coupler written in a glass sample by the focused 400-nm output from a 25-fs oscillator is reported. The coupler is single mode; the splitting ratio is 1.9 dB at 633 nm. A refractive-index profile of the waveguide with a magnitude of Δn=4.5×10-3 was retrieved from a near-field mode pattern.
TL;DR: This method introduces a single-mode continuous-wave laser into the cavity by use of an off-axis cavity alignment geometry to eliminate systematically the resonances commonly associated with optical cavities, while preserving the absorption signal amplifying properties of such cavities.
Abstract: A simple and easy to use method that allows high-finesse optical cavities to be used as absorption cells for spectroscopic purposes is presented. This method introduces a single-mode continuous-wave laser into the cavity by use of an off-axis cavity alignment geometry to eliminate systematically the resonances commonly associated with optical cavities, while preserving the absorption signal amplifying properties of such cavities. This considerably reduces the complexity of the apparatus compared with other high-resolution cavity-based absorption methods. Application of this technique in conjunction with either cavity ringdown spectroscopy or integrated cavity output spectroscopy produced absorption sensitivities of 1.5 x 10(-9) cm(-1) Hz(-1/2) and 1.8 x 10(-10) cm(-1) Hz(-1/2), respectively.
TL;DR: In this article, an overview of transition metal ion- and rare earth ion-doped crystals for application as tunable solid-state lasers is given, including recent research and advances in this field.
Abstract: In this work an overview of transition metal (TM) ion- and rare earth (RE) ion-doped crystals for application as tunable solid-state lasers will be given. Spectroscopic and laser results will be presented including recent research and advances in this field. Within this work tunability is defined as the possibility to achieve laser oscillation in the vibronic sideband of a transition. Tunable solid-state lasers are of interest for a wide field of applications, e.g. in scientific research, in medicine, for measurement and testing techniques, ultra short pulse generation, and communication. They can also be used as coherent light sources for second-harmonic generation, for optical parametric oscillators, and for sum- and difference-frequency generation. Tunable laser media based on 3d?3d transitions of transition-metal ions and 4f?5d transitions of rare-earth ions cover nowadays almost the whole spectral range between 270 nm and 4500 nm, see Fig. 1 [1-15]. In comparison to laser systems based on the 4f?4f transitions of trivalent rare-earth ions, tunable lasers based on 3d?3d and 4f?5d transitions are in general affected by a higher probability of excited-state absorption (ESA), a higher probability of non-radiative decay, and a higher saturation intensity leading to higher laser thresholds. Often laser oscillation cannot be obtained at all. These general topics will be considered in Sect. 1, where the basic aspects of tunable solid-state lasers are discussed: these are the preparational, the spectroscopic, and the laser aspect. In Sect. 2, the investigation of transition metal ion-doped crystals with respect to the realization of tunable laser oscillation is presented. The work is focused on transition-metal ions of the 3d row (Fe row) and divided into two subsections according to the octahedral and tetrahedral coordinations of the ion investigated. Each subsection is structured according to the electron configurations: 3d1, 3d3, 3d4, and 3d8 for the octahedrally coordinated ions and 3d1, 3d2, and 3d4 for the tetrahedrally coordinated ions. Section 3 deals with interconfigurational transitions of divalent and trivalent rare-earth ions. Finally, in Sect. 4 the work is summarized.
TL;DR: Optical coherence tomography shows large refractive-index changes of up to ~10(-2) in the waveguides; these changes are consistent with guided mode analysis.
Abstract: Single-mode X couplers and three-dimensional waveguides are fabricated in transparent glasses by use of an unamplified femtosecond laser generating energies of up to 100 nJ. Changing fabrication parameters such as power and scanning speed permits creation of waveguides with a wide range of structures and refractive-index difference. Optical coherence tomography shows large refractive-index changes of up to ∼10-2 in the waveguides; these changes are consistent with guided mode analysis.
TL;DR: This work has created a random laser that can be brought above and below its threshold for laser emission by small changes in its temperature, thereby creating a light source with a temperature-tunable colour spectrum.
Abstract: Random lasers have fascinating emission properties that lie somewhere between those of a conventional laser and a common light-bulb. We have created a random laser that can be brought above and below its threshold for laser emission by small changes in its temperature, thereby creating a light source with a temperature-tunable colour spectrum. As a single random laser can be made as small as a grain of tens of micrometres in diameter, we expect our device to find application in photonics, temperature-sensitive displays and screens, and in remote temperature sensing. Lasers are now commonplace - for example, they are used in industry and in hospitals, in bar-code scanners and compact-disc players. Conventional lasers are based on an optically active material and some sort of laser cavity that traps light for long enough for laser action to occur. A new type of laser source, known as a random laser, has been discovered that does not require a regular cavity but instead depends on a diffusive material such as a fine powder. In a random laser, light waves are trapped by multiple light scattering (that is, light diffusion), which takes over the role of the cavity in a regular laser (Fig. 1). The emission of a random-laser source has a well defined colour spectrum and can be pulsed, just like a regular laser, although its emission is in several directions because of the intrinsic randomness of the system.
TL;DR: It is concluded that the threshold parameters energy density and intensity are biologically independent from each other, accounting for the success and the failure in most of the cold laser uses since Mester's pioneering work.
Abstract: Objective: The purpose of this study was to assess and to formulate physically an irreducible set of irradiation parameters that could be relevant in the achieving reproducible light-induced effect...
TL;DR: In this article, a simple optical interference method to fabricate microperiodic structures was demonstrated, where a femtosecond laser pulse was split by a diffractive beam splitter and overlapped with two lenses.
Abstract: A simple optical interference method to fabricate microperiodic structures was demonstrated. Femtosecond laser pulse was split by a diffractive beam splitter and overlapped with two lenses. Temporal overlap of the split femtosecond pulses, which requires 10 μm order accuracy in optical path lengths, was automatically achieved by this optical setup. One-, two-, and three-dimensional periodic microstructures with micrometer-order periods were fabricated using this method.
TL;DR: It is shown that anticipated synchronization occurs in coupled time-delay systems, when the coupling has a delay that is less than the delay of the systems.
Abstract: The synchronization of chaotic semiconductor lasers with optical feedback is studied numerically in a one-way coupling configuration, in which a small amount of the intensity of one laser (master laser) is injected coherently into the other (slave laser). A regime of anticipated synchronization is found, in which the intensity of the slave laser is synchronized to the future chaotic intensity of the master laser. Anticipation is robust to small noise and parameter mismatches, but in this case the synchronization is not complete. It is also shown that anticipated synchronization occurs in coupled time-delay systems, when the coupling has a delay that is less than the delay of the systems.
TL;DR: In this paper, the authors review the many recent advances in high-field science, called high field science, and present a review of these advances in laser-based accelerators.
Abstract: As tabletop lasers continue to reach record levels of peak power, the interaction of light with matter has crossed a new threshold, in which plasma electrons at the laser focus oscillate at relativistic velocities. The highest forces ever exerted by light have been used to accelerate beams of electrons and protons to energies of a million volts in distances of only microns. Not only is this acceleration gradient up to a thousand times greater than in radio-frequency-based sources, but the transverse emittance of the particle beams is comparable or lower. Additionally, laser-based accelerators have been demonstrated to work at a repetition rate of 10 Hz, an improvement of a factor of 1000 over their best performance of just a couple of years ago. Anticipated improvements in energy spread may allow these novel compact laser-based radiation sources to be useful someday for cancer radiotherapy and as injectors into conventional accelerators, which are critical tools for x-ray and nuclear physics research. They might also be used as a spark to ignite controlled thermonuclear fusion. The ultrashort pulse duration of these particle bursts and the x rays they can produce, hold great promise as well to resolve chemical, biological or physical reactions on ultrafast (femtosecond) time scales and on the spatial scale of atoms. Even laser-accelerated protons are soon expected to become relativistic. The dense electron–positron plasmas and vast array of nuclear reactions predicted to occur in this case might even help bring astrophysical phenomena down to Earth, into university laboratories. This paper reviews the many recent advances in this emerging discipline, called high-field science.
TL;DR: High-repetition-frequency femtosecond lasers at low mean power in combination with high-numerical-aperture focusing optics appear therefore as appropriate noncontact tools for nanoprocessing of bulk and (or) surfaces of transparent materials such as chromosomes.
Abstract: Near-infrared laser pulses of a compact 80-MHz femtosecond laser source at 800 nm, a mean power of 15-100 mW, 170-fs pulse width, and millisecond beam dwell times at the target have been used for multiphoton-mediated nanoprocessing of human chromosomes. By focusing of the laser beam with high-numerical-aperture objectives of a scanning microscope to diffraction-limited spots and with light intensities of terawatts per cubic centimeter, precise submicrometer holes and cuts in human chromosomes have been processed by single-point exposure and line scans. A minimum FWHM cut size of ~100 nm during a partial dissection of chromosome 1, which is below the diffraction-limited spot size, and a minimum material removal of ~0.003mum (3) were determined by a scanning-force microscope. The plasma-induced ablated material corresponds to ~1/400 of the chromosome 1 volume and to ~65x10(3) base pairs of chromosomal DNA. A complete dissection could be performed with FWHM cut sizes below 200 nm. High-repetition-frequency femtosecond lasers at low mean power in combination with high-numerical-aperture focusing optics appear therefore as appropriate noncontact tools for nanoprocessing of bulk and (or) surfaces of transparent materials such as chromosomes. In particular, the noninvasive inactivation of certain genomic regions on single chromosomes within living cells becomes possible.