Topic
Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: Co-administration of SP with LA reduced the amount of lead that accumulated in both blood and liver tissue of the exposed rats and minimized the increased levels of lipid peroxidation, protein oxidation, DNA oxidative damage, and liver enzyme endpoints.
26 citations
TL;DR: It is suggested that Bacopa monniera can mitigate the lead induced-oxidative stress tissue specifically by pharmacologic interventions which encompass both chelation as well as antioxidant functions.
Abstract: Bacopa monniera is a rejuvenating herb for brain cells enhancing learning and cognitive ability. In the present investigation, the ameliorative effects of Bacopa monniera were examined against lead-induced oxidative stress in different regions of rat brain. Male rats were divided into five groups: control (1000 ppm sodium acetate) and exposed (1000 ppm lead acetate) for 4 weeks; DMSA (Meso-2,3-Dimercaptosuccinic acid)-treated (90 mg/kg body weight/day); Bacopa monniera-treated (BM) (10 mg/kg body weight/day) and a combination of BM + DMSA for seven consecutive days after 4 weeks of lead exposure. After treatment, the whole brain was isolated by sacrificing rats and four regions were separated namely cerebellum, hippocampus, frontal cortex and brain stem. Results indicated a significant (p < 0.05) increase in reactive oxygen species (ROS), lipid peroxidation products (LPP) and total protein carbonyl content (TPCC) in association with tissue metal content in all the four regions of brain for exposed...
26 citations
TL;DR: It was concluded from the study that calcium phytate might be employed as a natural protective factor against lead toxicity.
Abstract: Forty female MF1 mice were fed diets with and without calcium phytate. Addition of lead acetate resulted in toxic effects. After necropsy liver and kidneys were removed and analyzed for lead by flameless atomic absorption spectroscopy. Calcium phytate did not affect the nutritional status of the mice. It was concluded from the study that calcium phytate might be employed as a natural protective factor against lead toxicity. (JMT)
26 citations
Journal Article•
TL;DR: The results showed that the levels of both oxidized (ubiquinone) and reduced (UBiquinol) forms of coenzyme Q in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type.
Abstract: Lead is a persistent and common environmental contaminant, which chiefly plays a significant role in modern industry. Coenzyme Q acts as electron and proton carrier in mitochondria and functions as an antioxidant in its reduced form (ubiquinol). To investigate the hazardous effects of lead on the coenzyme Q level, rats were injected i.p. with lead acetate (5 mg/kg b.wt. daily for 6 weeks). Our results showed that the levels of both oxidized (ubiquinone) and reduced (ubiquinol) forms of coenzyme Q9 and Q10 in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type.
26 citations
TL;DR: Lead administration reduced the ability of the phase II reaction of drug metabolism, although glutathione depletion was not necessarily a critical factor for impairmen of GST per se.
26 citations