Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.

Mitochondrial oxidative phosphorylation: interaction of lead and inorganic phosphate.

Abstract: Several of the physiological and biochemical defects observed in the liver, kidney, and erythropoietic tissue of lead poisoned animals have been associated with altered mitochondrial structure and function (1-3). These observations suggested a direct effect of lead on the functional integrity of mitochondria. Reticulocytes incubated with 100 μM lead acetate (PbAc) for 3 hr were found to have a significant inhibition in O2 uptake. Exposure of actively respiring reticulocyte mitochondria to the same concentration of lead caused an immediate drop in oxidative activity (4, 5). Our preliminary studies with beef heart mitochondria indicated that the presence of inorganic phosphate in the incubation medium interfered with the interaction of lead with the mitochondrial membrane (6, 7). These findings, and the scarcity of information on the specific effects of lead on mitochondrial respiration, prompted an investigation of the dose-response relationship between lead concentration and mitochondrial oxidative phosph...

Beneficial Effect of Combined Administration of Vitamin C and Vitamin E in Amelioration of Chronic Lead Hepatotoxicity

Abstract: Introduction: Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for lead toxicity. The protective action of vitamins C and E against lead affects lipid hydroperoxide level and liver functions in male rats has been studied. Results: Administration of lead acetate (2%) in dirinking water for 3 months elevates plasma lipid hydroperoxide level, activities of aspartate aminotronsferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), cholesterol, triglycerides and low density lipoprotein (LDL) levels. On the other hand, reduced plasma glutathione (GSH), protein and high density lipoprotein (HDL) concentrations lowered significantly in lead (Pb) treated group. However, oral administration of vitamin C (Vit C) or vitamin E (Vit E) at dose level of 100 mg/kg body weight reduced the alterations in the previous parameters. On the other hand, co-administration of both vitamins (Vit C+ Vit E) to lead-treated rats led to the most significant decline in lipid hydroperoxide level, restoration of GSH level and exhibited more protection as compared with Vit C or Vit E separately. Conclusion: There is synergistic antioxidative effect between Vit C and Vit E that protects the liver from lead induced lipid peroxidation, suggesting that the antioxidant treatment may best be done using a balanced cocktail. .

Protective role of ginger on lead induced derangement in plasma testosterone and luteinizing hormone levels of male Sprague Dawley rats.

Abstract: Background : Lead is one of the most serious environmental threats to human health especially in developing countries. It damages multiple body systems including the reproductive system. Ginger’s antioxidant and androgenic activity is reported in multiple animal studies. The aim of this study was to investigate the ameliorative effect of Zingiber officinale (ginger) on lead induced derangement in plasma testosterone and luteinizing hormone (LH) levels of male rats. Methods: Sixty adult male Sprague Dawley rats were used in this study in four groups. Group A served as normal control, Group B received 0.3% lead acetate in drinking water, Group C and group D received supplementary 0.5 and 1 gm/Kg bodyweight of ginger respectively along with lead acetate in drinking water. Five rats from each group were sacrificed at the end of 2 nd , 4 th and 6 th weeks. Serum testosterone and LH levels were analysed using ELISA technique. Results: After co administration with different doses of ginger, serum testosterone level which was significantly decreased in lead treated group, showed a significant rise as compared to lead treated group. LH levels which had exhibited no significant change by lead treatment, after co administration with different doses of ginger, again showed no significant change. Conclusion: Oral administration of ginger ameliorated lead induced testicular toxicity in male rats by increasing serum testosterone level at all durations which might be a product of both its androgenic and antioxidant properties. Keywords: Lead toxicity, testosterone, luteinizing hormone, Zingiber officinale, male rats, antioxidant

In Vivo Lipid Peroxidation Responses of Tissues in Lead-Treated Swiss Mice

Abstract: A single intraperitoneal injection of lead acetate (200 mg/kg body weight) increased the lipid peroxidation potential (LPP) measured as thiobarbituric acid-reactive substance (TBA-RS) in different tissues of Swiss mice. All the tissues taken for experimentation, generated significantly higher amount of TBA-RS in lead-treated mice when compared with the respective control value. However, none of the tissues could correspond to the control value after the lapse of four weeks post-treatment. Possibilities of differential responsiveness of tissues to generate lipid peroxides in lead-treated mice have been discussed.