Topic
Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: The interaction of methionine or lysine with lead in the diet of chicks was studied and supplemented with DL-methionine improved body weight gain and partially alleviated the lead-induced growth depression.
Abstract: The interaction of methionine or lysine with lead in the diet of chicks was studied. In experiment 1, lead acetate to supply 0 or 1000 ppm lead was added to a diet that was either deficient in the total sulfur-containing amino acid (TSAA) content (62% of the requirement) or supplemented with DL-methionine to provide 100% of the requirement (NRC, 1977). Supplementing the 0 ppm lead diet with methionine improved body weight gain. Dietary addition of 1000 ppm lead significantly decreased body weight gain; however, supplemental methionine partially alleviated the lead-induced growth depression (methionine X lead interaction was significant). Liver glutathione levels were markedly increased by supplemental methionine and also by lead but no methionine X lead interaction was detected. In experiment 2, the interaction between an essential non-sulfur-containing amino acid, lysine, and dietary lead was investigated. Two levels of lead, 0 or 1000 ppm, were fed in diets either deficient or adequate in lysine (85 or 100% of the requirement, respectively). Addition of lysine to the lysine-deficient basal diet increased growth. The magnitude of the lead-induced growth depression was not affected by dietary lysine content. The lysine level of the diet did not influence the liver glutathione concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
21 citations
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TL;DR: It is suggested that lead treatment promoted NKA and K+ channels activation and these effects might contribute to the preservation of aortic endothelial function against oxidative stress.
21 citations
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TL;DR: It seems that lead acetate interacts with nitric oxide modulatory role in salivary gland function as well as L-arginine and L-NAME prevented lead-induced reduction in calcium concentration.
Abstract: The effects of lead acetate, L-arginine (nitric oxide precursor) and L-NAME (nitric oxide synthesis inhibitor) on rat submandibular secretory function were studied. Pure submandibular saliva was collected intraorally from anaesthetized rats by a micro polyethylene cannula using pilocarpine as secretagogue. Treatment for twenty-eight days with three doses of lead acetate (0.01%, 0.04%, 0.05% w/v) in drinking water caused significant alterations on salivary function. Salivary flow rate was decreased by lead at all doses used. The total protein concentration and amylase activity of saliva were both decreased by lead (0.04% and 0.05%). All doses of lead decreased saliva calcium concentrations. Two weeks' treatment of rats by L-arginine (2.25% w/v) and L-NAME (0.7% w/v) in drinking water also affected the saliva secretory function. L-Arginine caused increase in submandibular gland weight. The saliva flow rate was reduced by L-NAME. The total protein concentration of saliva was increased by L-arginine and decreased by L-NAME. Amylase activity was reduced by L-arginine treatment. Calcium concentration was reduced by L-arginine and increased by L-NAME. Concurrent L-arginine treatment with lead acetate recovered lead-induced reduction of flow rate but L-NAME potentiated it. Concurrent therapy of lead and L-NAME resulted in greater reduction of protein concentration when compared to that of lead. L-Arginine showed a preventive effect on lead-induced decrease of protein concentration. Both L-arginine and L-NAME prevented lead-induced reduction in calcium concentration. It is concluded that nitric oxide plays a role in salivary gland function. Also lead acetate inhibitory effect on submandibular function is somewhat diminished by L-arginine and partially increased by L-NAME. It seems that lead acetate interacts with nitric oxide modulatory role in salivary gland.
21 citations
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TL;DR: It is suggested that decreased hippocampus NO level may contribute to the Pb-induced deficits in learning and memory processes.
21 citations
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TL;DR: A dose-dependent effect on reproduction is indicated, with variations in the number of births and in pups' weight, at the weaning stage, with hemoglobin levels and erythrocyte numbers significantly decreased.
Abstract: The effects of exposure to high doses of lead on reproduction and development have been established, but not so those caused by low lead doses or the influence that life stage at which contact with the metal takes place might have. The aim of this work was to study the effects of 200 and 400 ppm lead acetate in drinking water on reproduction and development as well as on renal and hepatic parameters of rats at different life stages, from gestation to 3 mo postweaning. The results indicate a dose-dependent effect on reproduction, with variations in the number of births and in pups' weight. Development was mostly affected at the weaning stage, with hemoglobin levels and erythrocyte numbers significantly decreased. The lead levels in tissues, blood, urine, and feces along with selected renal and hepatic parameters (blood urea nitrogen, creatinine, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) were determined. There were histological, blood urea nitrogen, alanine aminotransferase, and alkaline phosphatase changes in the first month postweaning. After 3 mo, these changes are no longer evident, possibly because of metabolic adaptation.
21 citations