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Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.


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TL;DR: The results of this study indicate that during a continuous exposure the lead level in hair reflects its content in bone, and such phenomena did not occur during the postexposure period.
Abstract: The use of hair and bone as media in evaluation of lead exposure was investigated in this study. For 12–16 wk rats were given tap water containing lead acetate in the following concentrations: 41.7 mg Pb/L, 83.3 mg Pb/L, and 166.6 mg Pb/L. The animals were sacrificed every 4 wk and their tibia bones and hair were collected for determination of lead content. In control animals, the lead level amounted to 1.2 μg/g (range 0.8–1.3 μg/g) and 0.7 μg/g (range 0.4–2.0 μg/g) in bone and hair, respectively. In the treated rats the accumulation of lead in bone and hair occurred in a dose-dependent manner. A positive corelation (r=0.876) was established between the lead levels in bone and hair of the rats. The regression equation was as follows: μg Pb/g bone=0.842×μg Pb/g hair+1.868. After discontinuation of exposure, a significant decrease in the lead content in bone and hair was noticed. About 9 wk after cessation of treatment, the lead content in hair declined to the pre-exposure level, but 64% of the maximal lead concentration did remain in bone. The results of this study indicate that during a continuous exposure the lead level in hair reflects its content in bone. Such phenomena did not occur during the postexposure period.

21 citations

Journal ArticleDOI
01 May 2017-Animal
TL;DR: Investigation of lead (Pb) biosorption efficacy by two lactic acid bacteria species (LABs) in broiler chickens showed that L. pentosus ITA23 and L. acidipiscis ITA44 effectively biosorb and expel dietary Pb from gastrointestinal tract of chickens.
Abstract: To alleviate adverse effects of heavy metal toxicity, diverse range of removing methods have been suggested, that is usage of algae, agricultural by-products and microorganisms. Here, we investigated lead (Pb) biosorption efficacy by two lactic acid bacteria species (LABs) in broiler chickens. In an in vitro study, Pb was added to culture medium of LABs (Lactobacillus pentosus ITA23 and Lactobacillus acidipiscis ITA44) in the form of lead acetate. Results showed that these LABs were able to absorb more than 90% of Pb from the culture medium. In follow-up in vivo study, LABs mixture was added to diet of broiler chickens contained lead acetate (200 mg/kg). Pb exposure significantly increased lipid peroxidation and decreased antioxidant activity in liver. The changes were recovered back to normal level upon LABs supplementation. Moreover, addition of LABs eliminated the liver tissue lesion and the suppressed performance in Pb-exposed chicks. Analysis of liver and serum samples indicated 48% and 28% reduction in Pb accumulation, respectively. In conclusion, results of this study showed that L. pentosus ITA23 and L. acidipiscis ITA44 effectively biosorb and expel dietary Pb from gastrointestinal tract of chickens.

21 citations

Journal ArticleDOI
TL;DR: It is suggested that CoQ10 can act as a natural therapeutic agent to protect against the reproductive impairments associated with lead acetate exposure and improve testicular function by inhibiting Pb accumulation, oxidative stress, inflammation, cell death, and histopathological changes following PbAc exposure.
Abstract: Exposure to lead (Pb) causes multiorgan dysfunction including reproductive impairments. Here, we examined the protective effects of coenzyme Q10 (CoQ10) administration on testicular injury induced by lead acetate (PbAc) exposure in rats. This study employed four experimental groups ( ) that underwent seven days of treatment as follows: control group intraperitoneally (i.p.) treated with 0.1 ml of 0.9% NaCl containing 1% Tween 80 ( ), CoQ10 group that was i.p. injected with 10 mg/kg CoQ10, PbAc group that was i.p. treated with PbAc (20 mg/kg), and PbAc+CoQ10 group that was i.p. injected with CoQ10 2 h after PbAc. PbAc injection resulted in increasing residual Pb levels in the testis and reducing testosterone, luteinizing hormone, and follicle-stimulating hormone levels. Additionally, PbAc exposure resulted in significant oxidative damage to the tissues on the testes. PbAc raised the levels of prooxidants (malondialdehyde and nitric oxide) and reduced the amount of endogenous antioxidative proteins (glutathione and its derivative enzymes, catalase, and superoxide dismutase) available in the cell. Moreover, PbAc induced the inflammatory response as evidenced by the upregulation of inflammatory mediators (tumor necrosis factor-alpha and interleukin-1 beta). Further, PbAc treatment induced apoptosis in the testicular cells, as indicated by an increase in Bax and caspase 3 expression, and reduced Bcl2 expression. CoQ10 supplementation improved testicular function by inhibiting Pb accumulation, oxidative stress, inflammation, cell death, and histopathological changes following PbAc exposure. Our findings suggest that CoQ10 can act as a natural therapeutic agent to protect against the reproductive impairments associated with PbAc exposure.

21 citations

Journal ArticleDOI
TL;DR: It is demonstrated clearly that lead accumulated in rat brain during the suckling period remains relatively unchanged throughout adult life, while the concentrations in the blood and other soft tissues fall rapidly after weaning, thus the blood lead level cannot be used as a measure of the amount of lead in the brain.

21 citations

Journal ArticleDOI
TL;DR: Regional cerebrovascular permeability to nutrient tracers representing seven BBB transport classes was not impaired by lead treatment, but the PS estimates for the amino acids lysine and histidine and for thiamine were greater than control in some regions of the cerebral hemisphere.

21 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202352
2022110
202182
202087
201983
201887