Topic
Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: The results demonstrated that the cerebral delta-ALA-D activity is more sensitive to lead acetate than to cadmium and mercury, and hepatic tissue is the most resistant to presence of mercury chloride in assay medium.
20 citations
TL;DR: It is shown for the first time that subchronic intoxication with lead caused myocardial preparations in a wide range of lengths to respond by a decreases in the time and speed parameters of the isometric contraction while maintaining its amplitude and by a decrease in the passive stiffness of trabecules.
20 citations
TL;DR: To examine the effects of dietary fat on the levels of lead in the blood, 34-40-d-old male mice were fed normal or high-fat diets along with distilled water for an initial 48-h exposure period and Atomic absorption was used to analyze blood-lead levels.
Abstract: To examine the effects of dietary fat on the levels of lead in the blood, 34–40‐d‐old male mice were fed normal or high‐fat diets along with distilled water for an initial 48‐h exposure period. Following this session, subjects from each diet condition were administered either 0, 0.075, or 0.5% lead acetate through the drinking water during the next 48 h along with their respective diets. Atomic absorption was used to analyze blood‐lead levels. At each concentration of lead, the high‐fat diet increased the blood lead content over subjects fed the control diet. The highest blood lead levels were found in the 0.5% lead acetate, high‐fat diet condition. The importance of nutritional considerations in understanding lead toxicity is discussed.
20 citations
TL;DR: It is concluded that exposure to lead acetate is considered as hepatotoxic environmental pollutant and showed important roles to protect body against lipid peroxidation, which considered as the first step of cell membrane damage.
Abstract: Selenium and vitamin E are very effective antioxidant agents which play important roles in improv- ing and development of aquaculture sector. This study was conducted to determine the protective and treatment effects of vitamin E and selenium against lead toxicity. Administration of both vitamin E and selenium amelio- rated the adverse effects of lead acetate toxicity through significant increase in hemoglobin, packed cell volume, RBC count, WBC count, and lymphocytes compared to lead acetate-exposed groups especially after the 10th week. Also, it is revealed that severe decrease of total protein, calcium, phosphorous, and magnesium in lead acetate intoxicated group. On contrary, significant in- crease of blood parameters upon addition of vitamin E and selenium combined with/without lead. On the other hand, insignificant decreases of sAST, sALT, urea, and creatinine in group fed on vitamin E and selenium, while increase in lead acetate intoxicated group. Lead acetate caused increasing of lipid peroxidation level (malondialdehyde) and decreasing of superoxide dismut- ase activity and reduced glutathione level. From these results, it is concluded that exposure to lead acetate is considered as hepatotoxic environmental pollutant. Exposure to lead acetate induced significant effects on antioxidant status. Antioxidants (vitamin E and seleni- um) showed important roles to protect body against lipid peroxidation, which considered as the first step of cell membrane damage, in addition to the improvement of the endogenous antioxidant enzyme activities.
20 citations
TL;DR: The results suggest that the peroxidative fagility test as carried out with an osmotic test recorder may not be a valid indicator of the vitamin E status of animals exposed to lead.
Abstract: Weanling male rats were fed either a vitamin E-deficient Torula yeast diet fortified with selenium or the same diet supplemented with 100 ppm vitamin E. One group of rats fed each diet received plain distilled water, whereas another group received 250 ppm lead as lead acetate in the drinking water. After a 3 month feeding period, erythrocyte osmotic and peroxidative fragilities were determined in an osmotic test recorder. Dietary vitamin E had little or no effect on the osmotic fragility of red cells. Lead in the drinking water, however, decreased the osmotic fragility of red cells from deficient rats. Lead poisoning also markedly decreased the elevated peroxidative fragility characteristic of erythrocytes from vitamin E-deficient rats. This effect of lead in reducing the peroxidative fragility of red cells from deficient rats could be seen at levels as low as 25 ppm lead in the drinking water. Lead added in vitro decreased the peroxidative fragility of red cells from vitamin E-deficient non-poisoned rats, whereas neither mercury nor cadmium had such an effect. Lead may decrease the osmotic and peroxidative fragility of erythrocytes from vitamin E-deficient rats by "tanning" the red cell membrane. These results suggest that the peroxidative fagility test as carried out with an osmotic test recorder may not be a valid indicator of the vitamin E status of animals exposed to lead.
20 citations