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Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: Morphologically the neurons were minimally altered by lead intoxication until late in the disease process, and the observed neuronal damage supports the suggestion that it is secondary to vascular disruption.
Abstract: Developmental changes in the cerebellum of neonatal Long-Evans rats with lead encephalopathy were studied by Golgi technique and by light and electron microscopy. Lead encephalopathy was produced by administering daily doses of lead acetate (600 mg of lead acetate/kg of body weight) through an esophageal catheter. Histopathologic changes were observed at 3, 5, 8, 10, 13, and 15 days of age.
20 citations
TL;DR: The results showed that the levels of both oxidized and reduced forms of coenzyme Q9 and Q10 in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type as discussed by the authors.
20 citations
TL;DR: The present study focused on the following three items: lead tissue distribution; variation with habitat; and an evaluation of the levels of lead contamination in the city of Alcala de Henares.
Abstract: The increase in the amount of lead released into the environment in developed countries during the last two to three decades has resulted in a significant increase in lead levels in organisms from completely different environments. Several surveys have been made in urban areas with high traffic densities in an attempt to identify plant and animal species that might reflect environmental metal concentrations so that those species could be used as sensitive biological indicators of heavy metal contamination. Studies of lead accumulation in U.K. rock doves imply that use of this species as a pollution indicator would facilitate periodic monitoring of chronic lead exposure conditions in the urban environment. Laboratory investigations cannot readily reflect environmental conditions since the validity of extrapolating laboratory results, where high doses are administered over short-time periods, to the natural environment has been seriously questioned. The present study was made on four rock dove (Columbia livia) populations: two groups (males and females) were dosed with lead acetate in the laboratory and two groups of males were housed in different parts of the city of Alcala de Henares. Data on lead bioaccumulation were collected in two situations: the first was in a laboratory with controlled amounts ofmore » lead, while in the second situation the amounts reflected the actual environmental levels in Alcala de Henares. Lead levels were determined in two tissues: blood, which is the target of first impact in possible acute situations; and bone, which is the main tissue where lead accumulates and, therefore, very important during chronic exposure. The study focused on the following three items: (1) lead tissue distribution; (2) variation with habitat; and (3) an evaluation of the levels of lead contamination in the city of Alcala de Henares. 19 refs., 3 figs., 1 tab.« less
20 citations
TL;DR: The results revealed that phagocytic and lytic functions of the adherent blood cells collected from sublethal lead-injected toads and incubated with suspensions of Candida pseudotropicalis were affected negatively, and the evaluation of these parameters might be a reliable tool for the biological monitoring of the immune status of amphibians.
Abstract: Lead is an element of risk for the environment and human health and has harmful effects that may exceed those of other inorganic toxicants. The immune system is one of the targets of lead. Its immunomodulatory actions depend on the level of exposure, and it has been demonstrated that environmental amounts of the metal alter immune function. Very little information is available regarding the effect of the metal on different aspects of the immune system of lower vertebrates, in particular of amphibians. The aim of this study was to investigate the effect of sublethal lead (as acetate) on the function of polymorphonuclear cells of Bufo arenarum. The results revealed that phagocytic and lytic functions of the adherent blood cells collected from sublethal lead-injected toads and incubated with suspensions of Candida pseudotropicalis were affected negatively. The decrease of the phagocytic activity was correlated with increased blood lead levels (P < 0.0001). Additional information referred to the total and differential leukocyte counts was presented; the only difference found was in the number of blast-like cells that resulted augmented in the samples of lead-injected toads. It was concluded that the evaluation of these parameters might be a reliable tool for the biological monitoring of the immune status of amphibians.
20 citations
TL;DR: In this paper, surface structures and selectivities of lead-poisoned Pd or Pd/graphite catalysts were studied and two types of surface species, adsorbed lead and bulk lead, were identified by XRD or the potential sweep method.
20 citations