Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.

Protective Effects of Latex of Ficus carica L. against Lead Acetate-Induced Hepatotoxicity in Rats

Abstract: Ficus carica L. latex is used traditionally for many therapeutic purposes. Oxidative stress may be the main reason behind most histological and cellular effects of lead. The aim of this study was to investigate the possible hepatoprotective role of Ficus carica L .latex against lead acetate-induced oxidative stress in rats. In the present investigation, lead acetate (500 mg Pb/L) was given orally to male rats for 28 days to induce hepatotoxicity. The Ficus latex was found to contain high total phenols and flavonoids. The levels of hepatic markers such as alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) were significantly (P�<�0.05) increased in blood serum following lead acetate administration. Lead-induced oxidative stress in liver tissue was indicated by a significant (P�<�0.05) increase in the level of liver Malondialdehyde (MDA) and decreased levels of liver reduced glutathione (GSH) and superoxide dismutase (SOD). Histologically and ultrastructurally, the liver showed several histological alterations such as degeneration of hepatocytes by necrosis and apoptosis, fatty changes and inflammatory cells infiltration. Ficus latex (1mL of 1:50 diluted latex/kg b.wt) markedly attenuated the previous lead-induced biochemical alterations in serum and liver tissues (P�<�0.05) as well as the histological and cellular changes. From this study, it can be concluded that the Ficus latex showed effective hepatoprotective and antioxidative action against lead acetate-induced hepatotoxicity in rats.

The accumulation effect of lead on DNA damage in mice blood cells of three generations and the protection of selenium.

Abstract: The accumulation effect of lead on DNA damage and the protection of selenium against lead were studied in mice blood cells of three generations. The test animals were divided into four groups: controls, Pb group, Se group, Pb + Se group. Lead and Selenium were administered to mice in the drinking water. The concentrations of lead (in form of lead acetate) and selenium (in form of Kappa-selenocarrageenan) used in this paper were 1 microgram/ml and 0.25 microgram/ml respectively. The percentage of damaged cells (DNA comets) was examined and detected conveniently by the single-cell gel electrophoresis (comet) assay. Results showed that 1 microgram/ml lead did not damage the female mice blood cells of the first generation seriously. However, there was a significant damage effect in both sexes of the second and third generations, suggesting the accumulation effect of lead was very significant starting from the second generation. In addition, under normal physiological conditions, Kappa-Se did not appear to enhance the protective ability on DNA damage significantly, whereas under lead exposure conditions, administration of Kappa-Se displayed the occurrence of a good protection against lead intoxication which was started from the female mice of the second generation.

Oxidation of wool: the lead acetate test for hydrogen peroxide bleached wool

Abstract: The lead acetate test for distinguishing between untreated and hydrogen peroxide bleached wool has been investigated. The degree of darkening of the wool during lead acetate treatments is a function of pH, the maximum difference between untreated and bleached wool occurring at pH 5. The results indicate that hydrogen peroxide partially oxidizes the sulfur in wool and prevents the formation of lead sulfide. A mechanism by which lead sulfide is formed in untreated wool is described. CONTENTS Page