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Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.


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TL;DR: To identify the proteomic pattern in the cortex of young animals, pregnant female mice and pups were administrated with 150 mg sodium fluoride/L and/or 300 mg lead acetate/L in their drinking water to identify differently expressed protein spots.
Abstract: Both fluoride and lead can cross the blood-brain barrier and produce toxic effects on the central neural system, resulting in low learning and memory abilities, especially in children. In order to identify the proteomic pattern in the cortex of young animals, from the beginning of fertilization to the age of postnatal day 56, pregnant female mice and pups were administrated with 150 mg sodium fluoride/L and/or 300 mg lead acetate/L in their drinking water. Two-dimensional electrophoresis (2-DE) combined with mass spectrometry (MS) was applied to identify differently expressed protein spots. Results showed that there were eight proteins in the cortex that significantly changed, whose biological functions were involved in (1) energy metabolism (Ndufs1, Atp5h, Atp6v1b2), (2) cytoskeleton (Spna2, Tuba1a, Tubb2a), (3) glycation repair (Hdhd2), and (4) cell stress response (Hspa8). Based on the previous and current studies, ATPase, Spna2, and Hspa8 were shared by fluoride and lead both as common target molecules.

19 citations

Journal Article
TL;DR: Treatments with simvastatin caused protective effects on renal tissue of mice exposed to lead, however, there was no significant effect on urea and creatinine levels.
Abstract: Background: Lead is known to be a highly toxic heavy metal. There are a limited number of studies investigating the effects of antioxidants on lead-induced kidney damage. Statins are widely used drugs for the treatment of hypercholesterolaemia, but they also have other pleiotropic effects. The aim of this study was to determine the effect of different doses of simvastatin on biochemical and histopathological parameters in mice exposed to lead. Methods: Forty eight adult male mice were randomised into six groups. The control group received no lead. Group II was injected interaperitoneally with 60 mg/kg lead acetate and groups III-VI received intraperitoneally 5-10-20-40 mg/kg simvastatin plus 60 mg/kg lead. After 14 days, a stereological study was done in accordance with the principle of Cavalieri and serum concentrations of urea and creatinine were measured. Data were analyzed using SPSS software and ANOVA. Results: Lead acetate treatment caused collapse of glomeruli, glumerulosclerosis, necrosis and vacuolization in renal tubules. Administration of 20 mg of simvastatin reduced the severity of kidney damage. Glomerular volume in the groups treated with 40 mg of simvastatin was significantly different from the group treated with lead alone (P =0.001). The number of renal glomeruli in the group treated with 5 mg of simvastatin were significantly difference compared to the lead treated group (P =0.027). Serum concentrations of urea and creatinine were not significantly different in the groups treated with simvastatin compared to the group treated with lead alone. Conclusions: Treatments with simvastatin Caused protective effects on renal tissue of mice exposed to lead. However, there was no significant effect on urea and creatinine levels.

19 citations

Journal ArticleDOI
TL;DR: The effects of lead acetate and aging on temporally-spaced responding (differential reinforcement of low rate or DRL-20 seconds) were studied and lead-treated animals exhibited a more variable response to d-amphetamine and a more pronounced number of IRTs in the first class interval.
Abstract: The effects of lead acetate and aging on temporally-spaced responding (differential reinforcement of low rate or DRL-20 seconds) were studied. Three groups of animals were considered along with their respective controls. Neonate-treated Long-Evans

19 citations

Journal ArticleDOI
TL;DR: Mrp1 might play important roles in lead detoxification by Nrf2 in rats' testes, and significant increases were observed in the expressions of Mrp1 and NRF2 in two lead groups.

19 citations

Journal ArticleDOI
TL;DR: It appears that Pb 2+ exerts a generalized effect on energy metabolism and not on a specific step in glucose metabolism, which may explain partially the Pb2+‐induced changes observed in cholinergic function.
Abstract: The effect of chronic low-level lead (Pb2+) ingestion on the metabolic pathways leading to the acetyl moiety of acetylcholine (ACh) was examined. Cerebral cortex slices, prepared from untreated or Pb2+-exposed rats (600 ppm lead acetate in the drinking water for 20 days), were incubated in Krebs-Ringer bicarbonate buffer with 10 mM glucose and tracer amounts of [6-3H]glucose and either [6-14C]glucose or [3-14C] beta-hydroxybutyrate. Altering the concentration of Pb2+ in the drinking water produced a dose-related increase in blood and brain lead levels. When tissue from Pb2+-exposed rats was incubated with mixed-label glucose, incorporation into lacate, citrate, and ACh was considerably decreased, although no changes occurred in the 3H/14C rations. Similar effects of Pb2+ were found when 14C-labeled beta-hydroxybutyrate was substituted for the [14C]glucose. It appears from these data that Pb2+ exerts a generalized effect on energy metabolism and not on a specific step in glucose metabolism. The impairment of glucose metabolism may explain partially the Pb2+-induced changes observed in cholinergic function.

19 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202352
2022110
202182
202087
201983
201887