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Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.


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Journal ArticleDOI
TL;DR: Results indicate that lead acetate perturbs the hematopoietic balance of adult HSCs, associated with cellular mitochondria defects, increased intracellular ROS generation, and in vivo treatment with the antioxidant vitamin C led to reversion of the CD90(+)CD45(-) compartment functional decline.

18 citations

Journal ArticleDOI
TL;DR: The data indicate that the effects of environmental pollutants on reproduction in birds can be mediated through increased P450, thereby increasing the metabolism of steroid hormones and depressing concentration in circulation.
Abstract: In a previous study, the authors found that administration of phenobarbital to laying hens was associated with an increase in content of liver cytochrome P450 and a reduction of estradiol (E2) in serum. Thus, the authors hypothesized that other xenobiotics such as environmental toxicants that affect P450 might also affect E2 in laying hens. In experiment 1, the authors examined the effect of four environmental pollutants, three of which induced different isoenzymes of P450 and one inhibitor, on circulating E2 and related reproductive functions. Aroclor 1254 (PCB), 20 mg/d; dichlorodiphenyltrichloroethane (DDT), 40 mg/d; or benzo[a]pyrene (BZ), 5 mg/d, was administered for 5 d. An inhibitor, lead acetate, was injected for 2 d. Controls received corn oil or sodium acetate. No significant difference was observed due to administration of lead. Treatment with PCB or DDT decreased the concentration of E2 and increased P450. Only PCB significantly decreased plasma total calcium and egg lay. Therefore in experiment 2, the authors determined the dose-response effect of PCB. The PCB was given orally at doses of 0, 5, 10, and 25 mg in corn oil for 5 d. The depression of concentrations of E2 was associated with the induction of P450 in a dose-dependentmore » manner. Egg production and plasma total calcium were reduced by the two highest doses, but eggshell thickness was not different from control in all regimens. Plasma E2 and plasma total calcium were negatively correlated with induction of P450. BZ is not a strong inducer of P450 and had no effect on E2 or reproduction, whereas DDT and PCB had a profound effect on P450 with consequent depression of circulating E2. These data indicate that the effects of environmental pollutants on reproduction in birds can be mediated through increased P450, thereby increasing the metabolism of steroid hormones and depressing concentration in circulation.« less

18 citations

Journal ArticleDOI
TL;DR: Lead administration from conception through testing increased the probability and duration of transcorneally induced electroconvulsive seizures of 21 day old mice within all three genotypes, and both cocaine and amphetamine injections 15 min prior to ECS reduced the number of animals exhibiting seizures as well as the duration of seizures in both lead treated and control mice.
Abstract: Mice, genetically selected for differences in brain weight were employed Lead administration (05% lead acetate) from conception increased the proportion of 21 day old mice exhibiting seizures; total duration of observed seizures was also increased Mice from the low brain weight line more frequently exhibited seizures than either mice from the high brain weight line or the Binghamton heterogenous stock Although genome and lead administration alter bodyweight, the inability of bodyweight to predict seizure occurence and/or total duration of seizure within conditions also ws noted Lead administration from conception through testing increased the probability and duration of transcorneally induced electroconvulsive seizures of 21 day old mice within all three genotypes, and both cocaine and amphetamine injections 15 min prior to ECS reduced the number of animals exhibiting seizures as well as the duration of seizures in both lead treated and control mice

18 citations

Journal ArticleDOI
P. Tachon1, A. Laschi1, J.P. Briffaux1, G. Brain1, P. Chambon1 
TL;DR: Study using optical microscopy showed the typical renal lesions in mothers treated during pregnancy and an erythrodiapedesis in cerebral matter of the new-born at birth in pregnant monkeys.

18 citations

Journal ArticleDOI
TL;DR: Femur from the lead-exposed rats had higher carbonate content in bone mineral and (Ca2++Mg2++ Na+)/P ratio values, although no variations were observed in crystal maturity and crystallite size, which indicates a similar mechanism of bone maturation normally associated to age-related processes.

18 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202352
2022110
202182
202087
201983
201887