Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.

Selenium protects reproductive system and foetus development in a rat model of gestational lead exposure.

Abstract: Objective Lead is a common environmental contaminant. Lead accumulation in the body is especially dangerous for pregnant women and newborns. Selenium is a trace element which may rectify the damaging effects of lead. Here we tested potential protective effects of selenium against gestational lead exposure. Materials and methods Pregnant SD rats were exposed to 200 mg/L of lead acetate (given with water), with or without sodium selenite supplementation (2-8 mg/kg/day via intragastric administration). Pregnant rats not exposed to lead or selenium served as control animals. The outcomes in pregnant rats were serum lead and selenium levels, reproductive hormone (follicle-stimulating hormone, luteinizing hormone, prolactin, oestradiol, progesterone) levels, and uterine and ovarian morphological changes. The outcomes in the offspring were sex differentiation, survival rates (day 21 after birth), weight (days 0-35 after birth), weight of reproductive organs, and puberty onset (foreskin separation or vaginal opening). Results Selenium supplementation dose-dependently decreased serum lead levels, rectified reproductive hormone levels, and attenuated reproductive morphological changes caused by lead exposure. Lead exposure did not affect sex differentiation, but significantly (p Conclusions Gestational lead exposure causes damages to the reproductive system of pregnant rats, and negatively modulates growth and reproductive system development of the offspring. These adverse effects are rectified or attenuated by selenium supplementation.

Aggression and Open-field Activity of Lead-Exposed Mice

Abstract: Blood lead levels were increased 11 to 18 times in mice that ingested a 5 mg/ml solution of lead acetate for 2 or 4 weeks, with no effect on weight gain. Although the lead treatment produced neither mortality nor obvious abnormalities, it nevertheless inhibited the development of isolation-induced aggression which was characteristic on the basis of changes in motor activity.

Lead-Induced Reduction In Body And Kidney Weight Of Wistar Albino Rats Ameliorated By Ginkgo Biloba Extract (EGb 761)

Abstract: Objective To observe the effects of lead acetate on body and kidney weight of Wistar albino rats and the protective role of EGb 761 on weight changes 12 Methodology One hundred and twenty young male Wistar albino rats were randomly selected and divided into three groups, A, B and C, comprising of 40 animals Each group was further divided into four subgroups according to the duration of treatment, ie, one, two, four and six weeks Group A animals (control) were given 05 ml normal saline intraperitoneally (IP) daily Group B animals received lead acetate 8mg/kg body weight IP daily, whereas Group C animals received 100mg/kg body weight of EGb 761 through gavage and 8mg/kg body weight lead acetate through IP Initial and final body weights were taken and recorded After sacrificing the animals, the kidneys were retrieved, dried and weighed using the Sartorius balance 13 Results Group B animals showed overall decrease in the body weight, which was non-significant (p>005) after one week and became highly significant (p 005) after one and two weeks, while became significant (p 005) decrease in kidney weight of group B rats after one week whereas the decrease was highly significant (p 005) after six weeks of treatment 14 Conclusion EGb 761 effectively ameliorated the lead-induced changes in body and kidneys weight of the albino rats

Studies on the protective effects of ascorbic acid and thiamine on lead-induced lipid and protein oxidation as well as enzymatic alterations in some tissues of Cyprinus carpio

Abstract: The present study has been undertaken to evaluate the possible protective effects of ascorbic acid and thiamine on modulating lead-induced lipid and protein oxidation as well as metabolic enzyme alterations in some tissues of common carp. Fish were divided into 4 groups, as follows: group A served as control; group B received lead acetate (5 mg L−1, 15 days); and group C and D received ascorbic acid (500 mg kg−1 feed) and thiamine (50 mg kg−1 feed) respectively, in addition to lead acetate. Lead acetate exposure caused significant increase in MDA content in liver, kidney, and brain as well as carbonyl content in the liver compared with control group (P < 0.05). Significant increase was also observed in enzymatic activities of aspartate amino transferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in the liver and alanine aminotransferase (ALT) and LDH in the kidney following lead exposure. Thiamine, but not vitamin C, administration caused significant decrease of MDA concentration in the brain as compared to the group receiving only lead. Moreover, administration of these two vitamins in groups C and D attenuated the hepatic protein carbonyl contents to the levels that were not significantly different from control group. Ascorbic acid supplementation effectively decreased the Pb-induced augmented levels of hepatic AST, LDH, and ALP and renal LDH and ALT activities to the levels that were not significantly different relative to control group. Indeed, thiamine decreased the elevated levels of liver ALP and LDH and kidney ALT and LDH to the levels that had no significant difference with control group. The results of the present investigation show that these two vitamins might be considered as effective and safe preventive treatments in preserving tissues against toxic effects of lead in common carp.