Topic
Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: A comparison of lead concentrations between the organs of rats dosed days 1–10 and rats dose days 11–20 indicated that the latter accumulated less lead per gram of tissue (p < 0.05) than their younger litter mates.
Abstract: Newborn rat pups were treated in seven groups: Group 1, the control, was untreated and killed at birth (day 1); Groups 2, 3, and 4 were treated on postnatal days 1 through 10 with respectively saline or lead acetate, 5.0 mg/kg and 7.5 mg/kg body weight; Groups 5, 6, and 7 were treated with the same respective dosages on days 11 through 20. Cerebellum, cerebral cortex, brainstem plus hippocampus, liver, and blood were analyzed for lead. Neonatal rats killed at birth all contained some lead, the cerebellum having the highest concentration. Tissue from most treated groups accumulated lead in a dose-dependent manner. A comparison of lead concentrations between the organs of rats dosed days 1–10 and rats dosed days 11–20 indicated that the latter accumulated less lead per gram of tissue (p < 0.05) than their younger litter mates.
14 citations
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TL;DR: Weight loss, especially rapid weight loss, could result in lead toxicity in people with a history of prior excessive lead exposure, and there were no significant differences in blood and organ lead concentrations between the swimming and nonswimming groups.
Abstract: We studied the effects of weight loss and non-weight-bearing exercise (swimming) on blood and organ lead and essential metal concentrations in rats with prior lead exposure. Nine-week-old female Sprague-Dawley rats (n = 37) received lead acetate in their drinking water for 2 weeks, followed by a 4-day latency period without lead exposure. Rats were then randomly assigned to one of six treatment groups: weight maintenance with ad libitum feeding, moderate weight loss with 20% food restriction, and substantial weight loss with 40% food restriction, either with or without swimming. Blood lead concentrations were measured weekly. The rats were euthanized after a 4-week period of food restriction, and the brain, liver, kidneys, quadriceps muscle, lumbar spinal column bones, and femur were harvested for analysis for lead, calcium, copper, iron, magnesium, and zinc using atomic absorption spectrophotometry. Both swimming and nonswimming rats fed restricted diets had consistently higher blood lead concentrations than the ad libitum controls. Rats in the substantial weight loss group had higher organ lead concentrations than rats in the weight maintenance group. Rats in the moderate weight loss group had intermediate values. There were no significant differences in blood and organ lead concentrations between the swimming and nonswimming groups. Organ iron concentrations increased with weight loss, but those of the other metals studied did not. Weight loss also increased hematocrits and decreased bone density of the nonswimming rats. The response of lead stores to weight loss was similar to that of iron stores because both were conserved during food restriction in contrast to decreased stores of the other metals studied. It is possible that weight loss, especially rapid weight loss, could result in lead toxicity in people with a history of prior excessive lead exposure.
14 citations
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TL;DR: This is the first report to suggest that melatonin directly affects lead levels in organisms exposed to subacute lead intoxication, and examines the effects of melatonin on lead bio-distribution.
14 citations
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TL;DR: Brain lesions were similar to those occurring in human lead encephalopathy and included degenerative and proliferative changes of small vessels, ring hemorrhages, edema, perivascular hyalin droplets, rosette-like deposits of proteinaceous exudates, focal loss of myelin, astrogliosis and necrosis of hippocampal neurons.
Abstract: Necropsies were performed on 25 rhesus monkeys, three cebus monkeys and three baboons which had been fed leaded paint or lead acetate at various doses up to 666 days. The 31 test primates and six controls ranged in age from five days to about eight years. In addition, the brains of 13 subadult squirrel monkeys fed lead oxide and two controls were studied grossly and microscopically. Lead content of liver, kidney and brain correlated with clinical outcome and typical histologic changes. Neuropathologic lesions, most severe in the young, occurred in 28 of 43 test primates despite a paucity of neurological signs. Brain lesions were similar to those occurring in human lead encephalopathy and included degenerative and proliferative changes of small vessels, ring hemorrhages, edema, perivascular hyalin droplets, rosette-like deposits of proteinaceous exudates, focal loss of myelin, astrogliosis and necrosis of hippocampal neurons.
14 citations
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TL;DR: In this article, the authors evaluated the effect of Ellagic acid (EA) in a rodent model with lead-induced toxicity and found that EA treatment caused significant restoration in the level of serum biomarkers, tissue antioxidants and histological architecture of renal tissue.
14 citations