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Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: A 15-year research program on the behavioral effects of lead using herring gulls (Larus argentatus) and common terns (Sterna hirundo) as models is reviewed in this article.
Abstract: Lead is one of the most common metals in contaminated ecosystems. Although lead poisoning and mortality have long been known, little is known of the behavioral effects produced by low levels of lead in wild animals. Herein a 15-yr research program on the behavioral effects of lead using herring gulls (Larus argentatus) and common terns (Sterna hirundo), referred to as larids, as models is reviewed. The doses used in laboratory studies were sufficient to produce lead concentrations in feathers that were equivalent to those found in some birds living in the wild. The exposure consisted of a single or multiple intraperitoneal (ip) injection of lead acetate. Both dose and day of exposure influenced behavioral development in young larids, with most effects increasing with dose, and decreasing with age. Low-level lead affected growth, locomotion, balance, food begging, feeding, thermoregulation, depth perception, and individual recognition in laboratory and in wild birds. The accuracy of individual recognition ...
180 citations
TL;DR: Altered, reduced and oxidized GSH levels showed significant recovery after MiADMSA and DMSA administration while, vitamins E and C were effective in reducing GSSG and TBARS levels and increasing catalase activity, suggesting beneficial role of vitamin E when administered along with the thiol chelators.
175 citations
TL;DR: The results showed that lead acetate significantly increased the levels of ROS and MDA in mice, and severe DNA damage and ultrastructure alterations were obviously observed, which strongly suggests that lead may induce oxidative stress and change the expressions of apoptosis-related proteins in mouse liver.
164 citations
TL;DR: It is demonstrated that lead exposure promotes hydroxyl radical generation and induces oxidative stress in isolated endothelial cells, mimicking the effects observed in lead-exposed animals.
160 citations
TL;DR: Taurine seems to be capable of fortifying cells against lead-induced oxidative attack without decreasing lead levels, and administration of taurine, accompanied by a chelating agent, might increase its effectiveness in the treatment of lead poisoning.
Abstract: Oxidative stress is proposed as a molecular mechanism in lead toxicity, which suggests that antioxidants might play a role in the treatment of lead poisoning. The present study was designed to investigate whether taurine has a beneficial effect both on Chinese hamster ovary (CHO) cells and on Fisher 344 (F344) rats following lead exposure. Therefore, oxidative stress parameters (glutathione, malondialdehyde levels, catalase, and glucose-6-phosphate dehydrogenase [G6PD] activities) of lead-exposed CHO cells and F344 rats were determined following taurine treatment. Taurine was found to be effective in (1) increasing glutathione levels that had been diminished by lead; (2) reducing malondialdehyde levels, an end-product of lipid peroxidation; (3) decreasing catalase and erythrocyte G6PD activity, which had been increased by lead exposure; and (4) improving cell survival of CHO cells. However, taurine had no effect on blood and tissue lead levels when 1.1 g/kg/day taurine was administered to F344 rats for 7 days, following 5 weeks of lead exposure (2,000 ppm lead acetate). As a result, taurine seems to be capable of fortifying cells against lead-induced oxidative attack without decreasing lead levels. Therefore, administration of taurine, accompanied by a chelating agent, might increase its effectiveness in the treatment of lead poisoning.
160 citations