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Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: The collected data suggested that lead might interfere with catecholaminergic and particularly dopaminergic neurotransmission and the effect of the lead acetate on the uptake of dopamine in striatal synaptosomal preparations was examined.
57 citations
TL;DR: Fewer EAC rosettes were formed by splenic B lymphocytes from mice exposed to lead and cadmium than by B cells from control animals, which could account in part for suppression of the humoral immune response reported in previous studies.
57 citations
TL;DR: Of a group 32 workers of the lead manufacturing industry—3 with acute lead intoxication—there was no evidence of an increased aberration yield compared with a group of 20 persons from the average population.
Abstract: Human lymphocyte cultures were treated with different concentrations of lead acetate. The chromosome analysis revealed no significant differences in frequency and type of structural chromosome damage between this group and sodium acetate-treated and untreated control samples. Of a group 32 workers of the lead manufacturing industry—3 with acute lead intoxication—there was no evidence of an increased aberration yield compared with a group of 20 persons from the average population.
57 citations
TL;DR: The effects of chronic lead administration on renal function and cytoarchitecture and on the immunohistochemical localization of glutathione S-transferase (GST) isoenzymes were determined in this paper.
57 citations
TL;DR: Lead from CDARB sediment accumulated more readily in duckling blood and liver than reported in goslings, but at given concentrations was generally less toxic to ducklings.
Abstract: Sediment ingestion has been identified as an important exposure route for toxicants in waterfowl. The toxicity of lead-contaminated sediment from the Coeur d'Alene River Basin (CDARB) in Idaho was examined on posthatching development of mallard (Anas platyrhynchos) ducklings for 6 weeks. Day-old ducklings received either untreated control diet, clean sediment (24%) supplemented control diet, CDARB sediment (3,449 μg/g lead) supplemented diets at 12% or 24%, or a positive control diet containing lead acetate equivalent to that found in 24% CDARB. The 12% CDARB diet resulted in a geometric mean blood lead concentration of 1.41 ppm (WW) with over 90% depression of red blood cell ALAD activity and over threefold elevation of free erythrocyte protoporphyrin concentration. The 24% CDARB diet resulted in blood lead of 2.56 ppm with over sixfold elevation of protoporphyrin and lower brain weight. In this group the liver lead concentration was 7.92 ppm (WW), and there was a 40% increase in hepatic reduced glutathione concentration. The kidney lead concentration in this group was 7.97 ppm, and acid-fast inclusion bodies were present in the kidneys of four of nine ducklings. The lead acetate positive control group was more adversely affected in most respects than the 24% CDARB group. With a less optimal diet (mixture of two thirds corn and one third standard diet), CDARB sediment was more toxic; blood lead levels were higher, body growth and liver biochemistry (TBARS) were more affected, and prevalence of acid-fast inclusion bodies increased. Lead from CDARB sediment accumulated more readily in duckling blood and liver than reported in goslings, but at given concentrations was generally less toxic to ducklings. Many of these effects are similar to ones reported in wild mallards and geese within the CDARB.
56 citations