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Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: It is concluded that inhibition of RNA and protein synthesis is responsible for the sensitizing effect and that this inhibition is not operative through a decreased clearance of endotoxin, although the phagocytic capacity is impaired.
56 citations
TL;DR: It is concluded that lead acetate may be considered as strong cytotoxic and genotoxic agent on male reproductive function.
Abstract: The present study was conducted to assess the histopathological and cytotoxic effect of lead exposure on male reproductive function. Adult male rats were divided in 2 groups. The first as a control group was given distilled water as drinking, while the second was exposed to 2 g/l of lead acetate in distilled water during 35 days. The structural damage on tests parenchyma was investigated by histological study and supplemented by biochemical assay of testosterone level. DNA fragmentation in germinal cells was determined using terminal desoxynucleotidyl transferase mediated dUTP nick end-labeling (TUNEL) assay. The histological study showed that lead can induce pronounced alterations on germ cells. The testosterone level was significantly decreased in treated rats compared to controls. TUNEL assay revealed a significant DNA fragmentation index in rats exposed to lead. This study showed TUNEL assay can be used to determinate DNA fragmentation in germinal cells. Moreover, we conclude that lead acetate may be considered as strong cytotoxic and genotoxic agent on male reproductive function.
56 citations
TL;DR: Lead and cadmium did not significantly affect the response of lymphocyte proliferation by Con A and lipopolysaccharide as well as purified protein derivative (PPD), and group variation and interpretation of data are discussed.
55 citations
TL;DR: In this article, the authors investigated the effect of Chlorella vulgaris (CV) on the oxidative system of male Sprague-Dawley rats fed American Institute of Nutrition (AIN)-76 diet, plus 2, 5 or 10% CV for 4 weeks.
Abstract: Lead (Pb) is a toxic heavy metal widely distributed in the environment. Recent studies suggest oxidative stress as one possible mechanism involved in Pb poisoning. The unicellular algae Chlorella vulgaris (CV) contains various bioactive substances with antioxidant for the prevention of oxidative stress by metals. We investigated the protective effects of CV on the oxidative system in five groups of male Sprague-Dawley rats fed American Institute of Nutrition (AIN)-76 diet, plus 2, 5 or 10% CV for 4 weeks. All animals were exposed to 200 mg/l lead acetate by drinking water except for the control (tap water). Body weight gains were significantly reduced in the Pb-exposed group (64%) relative to the control and CV groups. Brain weights were significantly increased in the Pb-exposed group (44%) relative to the others. In the experimental period, food intake, water intake and Pb intake were not different among the groups. The levels of Pb (87%) in brain obtained from the Pb-exposed group were significantly increased compared to the other groups. The levels of oxidative stress parameters in the brain such as superoxide dismutase (36%), glutathione peroxidase (63%), and glutathione reductase (30%) were decreased in the Pb-exposed group relative to the control but markedly increased in the CV groups. The CV also significantly increased glutathione levels by approximately 1.7-fold over the Pb-exposed group, while the malondialdehye concentration significantly decreased by approximately 47-71%. Based on these results, we found alterations in several indicators of oxidative stress of Pb intoxication, suggesting the antioxidant potential of CV. Therefore, CV may have protective effects on brain damage of low-level and short-term Pb exposure in the brains of rats.
55 citations
TL;DR: A linear relationship was observed between blood lead concentration and dose following intravenous administration of lead and this provided empirical support for using blood lead concentrations at supposed steady state to compute the bioavailability of lead administered by different routes and from different sources.
55 citations